{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:27:26Z","timestamp":1784028446710,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JPGN rep."],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Vascular anomalies can cause extrinsic esophageal compression, leading to dysphagia or feeding difficulties in children. Diagnosis typically relies on imaging and endoscopy, which may under\u2010 or overestimate functional narrowing. Endoluminal functional lumen imaging probe (EndoFLIP) provides luminal parameters in real\u2010time, but its role in vascular compression is not well\u2010defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed children with vascular anomalies who underwent upper endoscopy with EndoFLIP (July 2021\u2013April 2025). Demographics, imaging, endoscopic\/EndoFLIP findings, and outcomes were recorded. In select cases, paired measurements at the lower esophageal sphincter (LES) and compression site were compared at matched balloon volumes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eight patients (mean age 12.1 years; range 6\u201317; 5 females) were included. Vascular anomalies included left aortic arch with aberrant right subclavian artery (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095), double aortic arch (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092), and right aortic arch with anomalous left subclavian artery (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091). EndoFLIP detected narrowing in 6\/8 (75%), compared with 4\/8 (50%) on endoscopy and 6\/7 (86%) on upper gastrointestinal (UGI) series. Two patients had narrowing on EndoFLIP despite normal endoscopy; two others had UGI narrowing but normal EndoFLIP and endoscopy. Paired measurements (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092) showed markedly reduced diameter and distensibility at the compression site versus the LES. Management included surgical repair (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093), dietary modification (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092), and proton\u2010pump inhibitor therapy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093), with variable symptom improvement. No procedural complications occurred.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>EndoFLIP was safe, feasible, and provided meaningful complementary physiologic information in this heterogeneous cohort. These preliminary findings support a potential diagnostic role for EndoFLIP in esophageal vascular compression, warranting confirmation in larger, standardized, prospective studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpr3.70140","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T08:29:00Z","timestamp":1768379340000},"page":"192-199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pediatric vascular compression of the esophagus: Endoluminal functional lumen imaging probe as a complement to imaging and endoscopy"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3048-5662","authenticated-orcid":false,"given":"Brett J.","family":"Hoskins","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics Indiana University School of Medicine, Riley Hospital for Children at IU Health Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paroma","family":"Bose","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics Indiana University School of Medicine, Riley Hospital for Children at IU Health Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan T.","family":"Pitman","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics Indiana University School of Medicine, Riley Hospital for Children at IU Health Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-023-03301-y"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2017160033"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.14309\/crj.0000000000000854"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.08.004"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-012-0187-x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003430"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-023-10129-3"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpn3.70013"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14161736"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003625"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(97)70003-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002494"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000003194"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12205"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.131"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.237"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14419"},{"key":"e_1_2_8_19_1","first-page":"S1028","article-title":"1833 utilization of EndoFLIP to diagnose achalasia in a patient with chronic dysphagia previously attributed to dysphagia lusoria","volume":"114","author":"Hundt MA","year":"2019","journal-title":"ACG Case Rep J"}],"container-title":["JPGN 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