{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T12:11:34Z","timestamp":1778155894529,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JPGN rep."],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Patients with inflammatory bowel disease (IBD) are at increased risk of vaccine\u2010preventable diseases. However, vaccination coverage in this population is often suboptimal. This retrospective study assessed the vaccination status and vaccine serology of children diagnosed with IBD in a high\u2010income country with broad vaccine access.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medical records of children under 16 years diagnosed with IBD between 2009 and 2023 were retrospectively reviewed. Demographic and clinical data, vaccine history, and vaccine serology, at the time of diagnosis, were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 42 IBD patients were included, with a median age at diagnosis of 11 years. Vaccine records were available for 31 (74%), of whom only 6 (19%) had up\u2010to\u2010date vaccinations. Vaccine serology did not always correlate with vaccine history. Most patients had the required doses for age for tetanus, diphtheria,\n                      <jats:italic>Haemophilus influenzae<\/jats:italic>\n                      Type B (Hib), and measles. In contrast, coverage was lower for Hepatitis B (61%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200919\/31), Hepatitis A (45%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200914\/31),\n                      <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n                      (55%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200917\/31), and varicella (32%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910\/31). Corresponding seroprotection rates varied: 90% for tetanus (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200919\/21), 92% for diphtheria (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912\/13), 80% for measles (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200916\/20), 76% for varicella (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200919\/25), 77% for Hib (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910\/13), but only 22% for\n                      <jats:italic>S. pneumoniae<\/jats:italic>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094\/18), 54% for Hepatitis B (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200913\/24), and 22% for Hepatitis A (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092\/9).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study reveals major gaps in vaccination coverage and seroprotection among children with IBD. Pneumococcal and Hepatitis A\/B vaccines should be given at diagnosis, and measles and varicella serology should be assessed to enable timely catch\u2010up with live vaccines before immunosuppression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpr3.70146","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T11:21:23Z","timestamp":1769512883000},"page":"289-295","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serological immunity against vaccine\u2010preventable diseases in children with inflammatory bowel disease at diagnosis"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1828-2686","authenticated-orcid":false,"given":"Clara","family":"Noble","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Geneva Geneva Switzerland"},{"name":"Research Platform of Pediatrics, Gynecology, and Obstetrics, Department of Pediatrics, Gynecology and Obstetrics Geneva University Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8164-7284","authenticated-orcid":false,"given":"Renato","family":"Gualtieri","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Geneva Geneva Switzerland"},{"name":"Research Platform of Pediatrics, Gynecology, and Obstetrics, Department of Pediatrics, Gynecology and Obstetrics Geneva University Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9464-5704","authenticated-orcid":false,"given":"Klara","family":"Posfay\u2010Barbe","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Division of General Pediatrics, Department of Pediatrics, Gynecology and Obstetrics Geneva University Hospitals and University of Geneva Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5315-9267","authenticated-orcid":false,"given":"Nathalie","family":"Rock","sequence":"additional","affiliation":[{"name":"Unit of Gastroenterology, Hepatology and Nutrition, Division of Pediatric Specialties, Department of Pediatrics, Gynecology and Obstetrics Geneva University Hospitals and University of Geneva Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9974-2172","authenticated-orcid":false,"given":"Geraldine","family":"Blanchard\u2010Rohner","sequence":"additional","affiliation":[{"name":"Unit of Immunology, Vaccinology, and Rheumatology, Division of General Pediatrics, Department of Pediatrics, Gynecology and Obstetrics Geneva University Hospitals and University of Geneva Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31824d1438"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2014.04.005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjab052"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izz264"},{"key":"e_1_2_8_6_1","volume-title":"Directives et recommandations","author":"Office f\u00e9d\u00e9ral de la sant\u00e9 publique, Commission f\u00e9d\u00e9rale pour les vaccinations","year":"2023"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2023.12.011"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.10.4.514-519.2003"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.05158-11"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00415-08"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-06976-x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21948"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_596_23"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2023.03.025"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2025.127288"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.12.079"},{"key":"e_1_2_8_17_1","unstructured":"Reminder alerts improve vaccination adherence among IBD patients [Internet]. 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