{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T12:11:28Z","timestamp":1778155888484,"version":"3.51.4"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JPGN rep."],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Crohn's disease (CD) and eosinophilic gastrointestinal diseases (EGIDs) are distinct inflammatory entities, but eosinophilic disease may emerge as a paradoxical immune complication of anti\u2013tumor necrosis factor therapy. We report a 12\u2010year\u2010old boy with terminal ileal CD who developed severe eosinophilic gastritis and ileitis, peripheral eosinophilia, and psoriasiform dermatitis during prolonged anti\u2010TNF treatment, despite CD remission. Corticosteroids, dietary modification, and sequential biologic therapy resulted in incomplete or transient responses. Following anti\u2010TNF withdrawal, eosinophilic disease persisted, prompting compassionate off\u2010label treatment with benralizumab, an interleukin\u20105 (IL\u20105) receptor \u03b1\u2010antagonist, alongside vedolizumab for CD maintenance. Benralizumab led to rapid normalization of peripheral eosinophil counts, resolution of gastrointestinal symptoms, improved food tolerance, and histologic remission at 6 months. This case illustrates persistent anti\u2010TNF\u2013associated immune deviation and supports targeted IL\u20105 receptor blockade as an effective strategy for refractory eosinophilic gastrointestinal disease while maintaining CD remission.<\/jats:p>","DOI":"10.1002\/jpr3.70164","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:25:34Z","timestamp":1773307534000},"page":"312-314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Benralizumab for anti\u2010tumor necrosis factor\u2010associated eosinophilic gastrointestinal disease in a child with ileal Crohn's: A case report"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9828-4538","authenticated-orcid":false,"given":"Jonathan","family":"Dudzik","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Liver Transplant Queensland Children's Hospital South Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Pinzon\u2010Charry","sequence":"additional","affiliation":[{"name":"Queensland Paediatric Immunology &amp; Allergy Service Queensland Children's Hospital South Brisbane Queensland Australia"},{"name":"Griffith University Nathan Campus Nathan Queensland Australia"},{"name":"University of Queensland, St Lucia Campus St Lucia Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Lewindon","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Liver Transplant Queensland Children's Hospital South Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fariha","family":"Balouch","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Liver Transplant Queensland Children's Hospital South Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000239"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003877"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13144119"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2015-000239"},{"issue":"1","key":"e_1_2_8_6_1","first-page":"113","article-title":"Benralizumab: a review of mechanisms of action and clinical evidence in eosinophilic asthma","volume":"20","author":"Busse W","year":"2019","journal-title":"Respir Res"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.438"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2019.08.102"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.07.044"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.02.037"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000646"}],"container-title":["JPGN Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpr3.70164","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jpr3.70164","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpr3.70164","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:30:29Z","timestamp":1778153429000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpr3.70164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,12]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/jpr3.70164"],"URL":"https:\/\/doi.org\/10.1002\/jpr3.70164","archive":["Portico"],"relation":{},"ISSN":["2691-171X","2691-171X"],"issn-type":[{"value":"2691-171X","type":"print"},{"value":"2691-171X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,12]]},"assertion":[{"value":"2025-11-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}