{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T15:57:04Z","timestamp":1786636624749,"version":"build-2736575974"},"reference-count":8,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JPGN rep."],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Peutz\u2013Jeghers syndrome (PJS) is a rare genetic disorder characterized by hamartomatous polyps and mucocutaneous hyperpigmented freckles, whereas Crohn's disease (CD) is a condition characterized by chronic intestinal inflammation. Here, we present a rare case report of an 11\u2010year\u2010old male who presented with both CD and PJS. To our knowledge, this is only the fifth case report describing both of these diseases in the same patient. While CD is relatively common in industrialized countries, having CD in conjunction with PJS is exceedingly rare. This paucity of data describing the coexistence of the two conditions in the same patient has led to a general lack of guidance and screening recommendations in patients with both of these diseases. It is known that each disorder alone increases a patient's risk of malignancy; however, more data are needed to determine the appropriate cancer screening algorithm for patients with these dual diagnoses as well as management approaches.<\/jats:p>","DOI":"10.1002\/jpr3.70184","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T11:10:06Z","timestamp":1775733006000},"page":"432-435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A case report of Peutz\u2013Jeghers syndrome in a child with Crohn's disease"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3172-930X","authenticated-orcid":false,"given":"Hasala","family":"Rannulu","sequence":"first","affiliation":[{"name":"Penn State College of Medicine Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eve","family":"May","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine Hershey Pennsylvania USA"},{"name":"Penn State Department of Pediatrics Penn State Hershey Medical Center Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethany","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine Hershey Pennsylvania USA"},{"name":"Penn State Department of Pediatrics Penn State Hershey Medical Center Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Cochran","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine Hershey Pennsylvania USA"},{"name":"Penn State Department of Pathology Penn State Hershey Medical Center Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Zdenek","sequence":"additional","affiliation":[{"name":"Penn State Department of Pediatric Genetics Penn State Hershey Medical Center Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefany H.","family":"Garrity","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine Hershey Pennsylvania USA"},{"name":"Penn State Department of Pediatrics Penn State Hershey Medical Center Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Edens Hurst AC. Peutz\u2013Jeghers syndrome. Mount Sinai Health System. Published December 31 2023.https:\/\/www.mountsinai.org\/health-library\/diseases-conditions\/peutz-jeghers-syndrome#:~:text=PJS small%20intestine%20and%20large%20intestine"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31711-1"},{"issue":"12","key":"e_1_2_7_4_1","first-page":"670","article-title":"Familial occurrence of Peutz\u2013Jeghers syndrome and Crohn disease with manifestation of both diseases in the same patient","volume":"23","author":"Posselt HG","year":"1985","journal-title":"Z Gastroenterol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.4166\/kjg.2013.62.4.243"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2020-234513"},{"issue":"1","key":"e_1_2_7_7_1","first-page":"76","article-title":"A rare case of Crohn's disease associated with Peutz\u2013Jeghers syndrome","volume":"7","author":"Badre W","year":"2024","journal-title":"Asian J Res Rep Gastroenterol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.435"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000003465"}],"container-title":["JPGN Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpr3.70184","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jpr3.70184","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpr3.70184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:59:07Z","timestamp":1786633147000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpr3.70184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,9]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/jpr3.70184"],"URL":"https:\/\/doi.org\/10.1002\/jpr3.70184","archive":["Portico"],"relation":{},"ISSN":["2691-171X","2691-171X"],"issn-type":[{"value":"2691-171X","type":"print"},{"value":"2691-171X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,9]]},"assertion":[{"value":"2025-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}