{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:10:16Z","timestamp":1778152216190,"version":"3.51.4"},"reference-count":10,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JPGN rep."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Myeloid sarcoma (MS) is an extramedullary tumor of myeloid precursor cells, frequently associated with acute myeloid leukemia (AML), and rarely occurring in isolation. We present a child with obstructive jaundice secondary to a pancreatic head mass. Initial imaging was consistent with pancreatic hematoma; however, continued symptoms led to endoscopic ultrasound (EUS)\u2010guided biopsies that raised concern for autoimmune pancreatitis. Further histological and cytogenetic analysis confirmed pancreatic MS associated with a RUNX1::RUNX1T1 fusion. Bone marrow evaluation was negative by conventional diagnostic methods; however, reverse transcriptase with qualitative real\u2010time polymerase chain reaction (RT\u2010qPCR) detected RUNX1::RUNX1T1 transcripts. Chemotherapy achieved both radiologic resolution and disappearance of RUNX1::RUNX1T1 transcripts within the bone marrow. This represents one of the first reported cases of isolated pancreatic MS in a child, without progression to AML. Our case highlights the diagnostic challenges of pancreatic masses, the underutilization of EUS\u2010guided biopsy in pediatrics, and the use of RT\u2010qPCR for both diagnosis and disease resolution.<\/jats:p>","DOI":"10.1002\/jpr3.70192","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T10:11:50Z","timestamp":1778148710000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Myeloid sarcoma presenting as an isolated pancreatic mass in a 3\u2010year\u2010old child"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9433-1824","authenticated-orcid":false,"given":"Jappmann Kaur","family":"Monga","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology &amp; Nutrition Medical College of Wisconsin Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cara L.","family":"Mack","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology &amp; Nutrition Medical College of Wisconsin Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Saad","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Gastroenterology, Hepatology &amp; Nutrition, Cincinnati Children's Hospital Medical Center Cincinnati College of Medicine Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dylan","family":"Applin","sequence":"additional","affiliation":[{"name":"Department of Radiology, Children's Wisconsin Medical College of Wisconsin Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maisam","family":"Abu\u2010El\u2010Haija","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Gastroenterology, Hepatology &amp; Nutrition, Cincinnati Children's Hospital Medical Center Cincinnati College of Medicine Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Vitale","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Gastroenterology, Hepatology &amp; Nutrition, Cincinnati Children's Hospital Medical Center Cincinnati College of Medicine Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary","family":"Graff","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Hematology, Oncology and Stem\u2010Cell Transplantation Medical College of Wisconsin Wauwatosa Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5211-4105","authenticated-orcid":false,"given":"Gila","family":"Ginzburg","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology &amp; Nutrition Medical College of Wisconsin Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2024\/5513857","article-title":"Pancreatic myeloid sarcoma causing obstructive jaundice: a case report and literature review","volume":"2024","author":"Lavette LE","year":"2024","journal-title":"Case Rep Gastrointest Med"},{"issue":"3","key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.5045\/br.2017.52.3.184","article-title":"Clinical characteristics and treatment outcomes of isolated myeloid sarcoma without bone marrow involvement: a single\u2010institution experience","volume":"52","author":"Lee JY","year":"2017","journal-title":"Blood 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myeloid leukemia in children","volume":"56","author":"Miri\u2010aliabad G","year":"2021","journal-title":"Turk Arch Pediatr"},{"key":"e_1_2_7_11_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.hpr.2022.300627","article-title":"Rare isolated pancreatic myeloid sarcoma in a pediatric patient \u2010 A case study with literature review","volume":"28","author":"Alsolami S","year":"2022","journal-title":"Hum Pathol Rep"}],"container-title":["JPGN 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