{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T11:08:21Z","timestamp":1783940901984,"version":"3.55.0"},"reference-count":7,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JPGN rep."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hereditary fructose intolerance (HFI) typically presents in infancy with acute metabolic crisis upon the introduction of fructose. We report a case of a 13\u2010year\u2010old female with chronic abdominal pain, short stature, and persistent mild transaminitis. Despite a late presentation, hepatic steatosis was identified on ultrasound and biopsy. Genetic testing confirmed a homozygous pathogenic ALDOB variant. This case illustrates that self\u2010imposed dietary avoidance can mask classic HFI symptoms, leading to a delayed diagnosis of \u201clean\u201d hepatic steatosis in adolescence.<\/jats:p>","DOI":"10.1002\/jpr3.70197","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T10:57:09Z","timestamp":1783940229000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Delayed diagnosis of hereditary fructose intolerance presenting as chronic lean steatosis in an adolescent"],"prefix":"10.1002","author":[{"given":"Alexandra","family":"Hurlock","sequence":"first","affiliation":[{"name":"Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Lah","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular Genetics Indiana University School of Medicine\/Riley Hospital for Children Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah Sue","family":"Hyaduck","sequence":"additional","affiliation":[{"name":"Division of Pathology Indiana University School of Medicine\/Riley Hospital for Children Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean P.","family":"Molleston","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition Indiana University School of Medicine\/Riley Hospital for Children Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8076-9378","authenticated-orcid":false,"given":"Chaowapong","family":"Jarasvaraparn","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition Indiana University School of Medicine\/Riley Hospital for Children Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"GaughanS AyresL BakerIIPR. Hereditary fructose intolerance. In: Adam MP Bick S Mirzaa GM Pagon RA Wallace SE Amemiya A eds.GeneReviews(\u00ae). University of Washington Seattle; 1993."},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2019-3324","article-title":"Pitfalls in the diagnosis of hereditary fructose intolerance","volume":"146","author":"Kim AY","year":"2020","journal-title":"Pediatrics"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.clnu.2019.02.019","article-title":"Non\u2010alcoholic fatty liver in hereditary fructose intolerance","volume":"39","author":"Ald\u00e1miz\u2010Echevarr\u00eda L","year":"2020","journal-title":"Clin Nutr"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1007\/s00018-019-03348-2","article-title":"Recent advances in the pathogenesis of hereditary fructose intolerance: implications for its treatment and the understanding of fructose\u2010induced non\u2010alcoholic fatty liver disease","volume":"77","author":"Buziau AM","year":"2020","journal-title":"Cell Mol Life Sci"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.5409\/wjcp.v11.i4.321","article-title":"Hereditary fructose intolerance: a comprehensive review","volume":"11","author":"Singh SK","year":"2022","journal-title":"World J Clin Pediatr"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/0140-6736(90)90603-3","article-title":"Molecular analysis of aldolase B genes in hereditary fructose intolerance","volume":"335","author":"Cross NCP","year":"1990","journal-title":"Lancet"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.3390\/nu11102397","article-title":"Daily fructose traces intake and liver injury in children with hereditary fructose intolerance","volume":"11","author":"Di Dato F","year":"2019","journal-title":"Nutrients"}],"container-title":["JPGN Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpr3.70197","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jpr3.70197","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpr3.70197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T10:57:11Z","timestamp":1783940231000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpr3.70197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,13]]},"references-count":7,"alternative-id":["10.1002\/jpr3.70197"],"URL":"https:\/\/doi.org\/10.1002\/jpr3.70197","archive":["Portico"],"relation":{},"ISSN":["2691-171X","2691-171X"],"issn-type":[{"value":"2691-171X","type":"print"},{"value":"2691-171X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,13]]},"assertion":[{"value":"2026-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jpr3.70197"}}