{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:11:48Z","timestamp":1784542308011,"version":"3.55.0"},"reference-count":9,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JPGN rep."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the outputs and clinical impact of a Cross\u2010Trust Histopathology Multidisciplinary Team (MDT) created to support diagnostic clarification and management of complex paediatric inflammatory bowel disease (IBD) cases, particularly during transition to adult services.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective review of eight MDT meetings held from January 2021 to March 2024 was performed. Patients were included if referred for diagnostic uncertainty, complex disease behaviour or transition planning. Extracted data included demographics, reason for referral, MDT\u2010agreed diagnosis, therapeutic recommendations and transition\u2010related decisions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010seven patients (mean age 17.2 years; range: 14\u201321) were discussed. Diagnostic clarification was the primary referral reason. Following MDT review, 11 patients (41%) had a change in diagnosis, including reclassification of IBD\u2010unclassified to ulcerative colitis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097) or Crohn's disease (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093). One patient was reclassified as having non\u2010IBD (disuse colitis). Management recommendations changed in three patients (11%), including biologic initiation or escalation. One patient (4%) had a modification to their transition pathway. MDT outputs were uploaded into the paediatric electronic health record in only three cases (11%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The Cross\u2010Trust Histopathology MDT improved diagnostic precision in complex paediatric IBD and influenced management in selected cases. The model supports harmonized interpretation across paediatric and adult services and promotes safer transition planning. Documentation of MDT outcomes remains an area for improvement. Wider adoption of similar collaborative frameworks may enhance diagnostic consistency and optimize care for adolescents with IBD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpr3.70201","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T09:54:39Z","timestamp":1784541279000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The \u2018Cross\u2010Trust\u2019 Histopathology Multidisciplinary Team: Report of meeting outputs and impact on paediatric inflammatory bowel disease management in a UK tertiary centre"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3328-0734","authenticated-orcid":false,"given":"Valeria","family":"Dipasquale","sequence":"first","affiliation":[{"name":"Department of Paediatric Gastroenterology Sheffield Children's Hospital NHS Foundation Trust and University of Sheffield Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alenka J.","family":"Brooks","sequence":"additional","affiliation":[{"name":"Academic Department of Gastroenterology Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Histopathology Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Bury","sequence":"additional","affiliation":[{"name":"Department of Histopathology Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshay","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology Sheffield Children's Hospital NHS Foundation Trust and University of Sheffield Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Narula","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology Sheffield Children's Hospital NHS Foundation Trust and University of Sheffield Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,20]]},"reference":[{"issue":"1","key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/ibd.21349","article-title":"Epidemiology of pediatric inflammatory bowel disease: a systematic review of international trends","volume":"17","author":"Benchimol EI","year":"2011","journal-title":"Inflamm Bowel Dis"},{"issue":"3","key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1159\/000501519","article-title":"An overview of inflammatory bowel disease unclassified in children","volume":"4","author":"Thurgate LE","year":"2019","journal-title":"Inflamm Intest 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K","year":"2024","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"6","key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1111\/jgh.16176","article-title":"Clinical outcomes in pediatric inflammatory bowel disease patients: a systematic review of prospective studies","volume":"38","author":"Van Hecke J","year":"2023","journal-title":"J Gastroenterol Hepatol"},{"issue":"14","key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"4813","DOI":"10.3390\/jcm12144813","article-title":"Benefits of paediatric to adult transition programme in inflammatory bowel disease: the BUTTERFLY study of GETECCU and SEGHNP","volume":"12","author":"Rub\u00edn de C\u00e9lix C","year":"2023","journal-title":"J Clin Med"},{"issue":"13","key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.3390\/diagnostics14131384","article-title":"Diagnostic procedures for inflammatory bowel disease: laboratory, endoscopy, pathology, imaging, and beyond","volume":"14","author":"Hong SM","year":"2024","journal-title":"Diagnostics"},{"issue":"4","key":"e_1_2_7_10_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.modpat.2025.100705","article-title":"Future of artificial intelligence\u2014machine learning trends in pathology and medicine","volume":"38","author":"Hanna MG","year":"2025","journal-title":"Mod Pathol"}],"container-title":["JPGN 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