{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:48:53Z","timestamp":1786978133980,"version":"build-2736575974"},"reference-count":10,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JPGN rep."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The rising incidence of pediatric\n                    <jats:italic>Clostridioides difficile<\/jats:italic>\n                    infection (CDI), particularly in medically complex patients, calls for novel, individualized treatments. While fecal microbiota transplantation (FMT) is well\u2010described for recurrent CDI, this report describes the first pediatric case of fulminant CDI with toxic megacolon successfully treated with FMT. This critically ill patient experienced failure of standard\u2010of\u2010care antibiotics and was a poor surgical candidate due to neutropenia and abdominal radiation for rhabdomyosarcoma. Ultimately, FMT rapidly resolved the patient's symptoms without adverse events. FMT should be considered for pediatric fulminant CDI.\n                  <\/jats:p>","DOI":"10.1002\/jpr3.70209","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T08:59:26Z","timestamp":1785142766000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pediatric\n                    <i>Clostridiodes difficile<\/i>\n                    infection with toxic megacolon successfully treated with fecal microbiota transplantation"],"prefix":"10.1002","author":[{"given":"Dana","family":"McCarney","sequence":"first","affiliation":[{"name":"Tufts University School of Medicine Boston Massachusetts USA"},{"name":"Division of Gastroenterology, Hepatology &amp; Nutrition Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4802-862X","authenticated-orcid":false,"given":"Pamela","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology &amp; Nutrition Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna","family":"Simes","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology &amp; Nutrition Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8001-6955","authenticated-orcid":false,"given":"Stacy A.","family":"Kahn","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology &amp; Nutrition Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jpeds.2020.02.005","article-title":"Epidemiology and risk factors for community associated clostridioides difficile in children","volume":"221","author":"Miranda\u2010Katz M","year":"2020","journal-title":"J Pediatr"},{"issue":"1","key":"e_1_2_8_3_1","first-page":"e1","article-title":"Fecal microbiota transplantation for severe or fulminant clostridioides difficile infection: systematic review and meta\u2010analysis","volume":"5","author":"Song YN","year":"2021","journal-title":"J Can Assoc Gastroenterol"},{"issue":"6","key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"E2023062922","DOI":"10.1542\/peds.2023-062922","article-title":"Fecal microbiota transplantation: information for the pediatrician","volume":"152","author":"Oliva\u2010Hemker M","year":"2023","journal-title":"Pediatrics"},{"issue":"1","key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"e239","DOI":"10.1542\/peds.2009-3363","article-title":"Fecal bacteriotherapy for relapsing Clostridium difficile infection in a child: a proposed treatment protocol","volume":"126","author":"Russell G","year":"2010","journal-title":"Pediatrics"},{"issue":"12","key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1038\/ajg.2012.351","article-title":"Colonoscopic fecal microbiota transplant for recurrent Clostridium difficile infection in a child","volume":"107","author":"Kahn SA","year":"2012","journal-title":"Am J Gastroenterol"},{"issue":"3","key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.cgh.2019.04.037","article-title":"Efficacy of fecal microbiota transplantation for Clostridium difficile infection in children","volume":"18","author":"Nicholson MR","year":"2020","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"8","key":"e_1_2_8_8_1","doi-asserted-by":"crossref","DOI":"10.14309\/crj.0000000000000198","article-title":"Fulminant Clostridium difficile infection cured by fecal microbiota transplantation in a bone marrow transplant recipient with critical neutropenia","volume":"6","author":"Krajicek E","year":"2019","journal-title":"ACG Case Rep J"},{"issue":"4","key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.14740\/gr1436","article-title":"Fecal microbiota transplantation in patients with recurrent clostridium difficile infection: a four\u2010year single\u2010center retrospective review","volume":"14","author":"Ashraf MF","year":"2021","journal-title":"Gastroenterol Res"},{"issue":"39","key":"e_1_2_8_10_1","doi-asserted-by":"crossref","first-page":"7174","DOI":"10.3748\/wjg.v23.i39.7174","article-title":"Faecal microbiota transplantation in patients with Clostridium difficile and significant comorbidities as well as in patients with new indications: a case series","volume":"23","author":"Lahtinen P","year":"2017","journal-title":"World J Gastroenterol"},{"issue":"3","key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1097\/MPG.0000000000002944","article-title":"Two\u2010step testing for Clostridioides difficile is inadequate in differentiating infection from colonization in children","volume":"72","author":"Parnell JM","year":"2021","journal-title":"J Pediatr Gastroenterol Nutr"}],"container-title":["JPGN Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpr3.70209","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jpr3.70209","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpr3.70209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T08:59:27Z","timestamp":1785142767000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpr3.70209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,27]]},"references-count":10,"alternative-id":["10.1002\/jpr3.70209"],"URL":"https:\/\/doi.org\/10.1002\/jpr3.70209","archive":["Portico"],"relation":{},"ISSN":["2691-171X","2691-171X"],"issn-type":[{"value":"2691-171X","type":"print"},{"value":"2691-171X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,27]]},"assertion":[{"value":"2025-10-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jpr3.70209"}}