{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T07:30:54Z","timestamp":1786692654555,"version":"build-2736575974"},"reference-count":10,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JPGN rep."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Recurrent episodic abdominal pain and vomiting, with symptom\u2010free intervals between attacks, represent common and often challenging presentations in children, typically leading to extensive workups without a clear etiology, as standard diagnostic algorithms fail to include rare systemic conditions. We present the challenging diagnostic odyssey of a pediatric patient (symptom onset at age 4 years; diagnosis at age 8), culminating in an unexpected diagnosis of hereditary angioedema, a critical etiology often omitted from differentials. This case underscores a key gap in current clinical pathways and serves to expand the diagnostic consideration for specialists managing unexplained recurrent episodic abdominal symptoms.<\/jats:p>","DOI":"10.1002\/jpr3.70232","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T07:01:36Z","timestamp":1786690896000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pediatric hereditary angioedema presenting as recurrent episodic abdominal pain and vomiting: Challenges in diagnosis and management"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3307-5845","authenticated-orcid":false,"given":"Julio Nestor","family":"Busaniche","sequence":"first","affiliation":[{"name":"Pediatrics Department Hospital Italiano de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4922-836X","authenticated-orcid":false,"given":"Jhoanna Valery Adauto","family":"Luizaga","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Hepatology and Liver Intestinal Transplantation Unit Hospital Italiano de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5699-8277","authenticated-orcid":false,"given":"Maria Soledad","family":"Arcucci","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Hepatology and Liver Intestinal Transplantation Unit, Hospital Italiano de Buenos Aires and Gastroenterology Unit Hospital de Ni\u00f1os Ricardo Guti\u00e9rrez Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6936-5599","authenticated-orcid":false,"given":"Claudio Alberto 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