{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:02:59Z","timestamp":1789437779424,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JPGN rep."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Identifying predictors of clinical remission in pediatric ulcerative colitis (UC) will impact the therapeutic approach. We aimed to predict time to first (TFR), corticosteroid\u2010free (TCSFR, \u22653 months corticosteroid withdrawal), and sustained remission (TSR, \u22656 months).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective study analyzed de\u2010identified prospectively collected data from 2383 patients enrolled in ImproveCareNow (2007\u20132023). We included UC patients under 18 years at diagnosis. Remission was defined as a Pediatric UC Activity Index (PUCAI; &lt;10 points). The Statistical Package for the Social Sciences version 29 with multiple imputation for missing data was used for statistical analysis. Cox regression identified predictors at diagnosis\/enrollment (T0) or first visit (T1) on the outcomes (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091785). This study received ethics committee approval (23135\u2010ICN_UC).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean TFR was 177.7 days, predicted by disease extent (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05) at T0 and history of severe UC (hazard ratio [HR]\u2009=\u20091.142,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05) before inclusion. In patients not reaching remission at T1 (subgroup;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009964), TFR was predicted by PUCAI (confounder; moderate HR\u2009=\u20090.867 or severe disease HR\u2009=\u20090.697,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.1) at T1 and history of severe UC (HR\u2009=\u20091.292,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007) before T1 (mean 25 days SEM 0.7). Mean TCSFR was 569.6 days, predicted by PUCAI (only mild HR\u2009=\u20090.728 and moderate HR\u2009=\u20090.559,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and use of corticosteroids (HR\u2009=\u20090.668,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) at T1 (mean 32 days SEM 0.9). Mean TSR was 631.0 days, predicted by PUCAI (only mild HR\u2009=\u20090.721 and moderate HR\u2009=\u20090.541,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and the use of oral aminosalicylates (HR\u2009=\u20090.793,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) at T1 (mean 30 days SEM 0.7).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Several clinical parameters in early disease course predict remission with increasing PUCAI as useful negative predictor.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpr3.70234","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T01:41:01Z","timestamp":1789436461000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The ImproveCareNow Registry: Prediction of different remission rates in pediatric ulcerative colitis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4519-0245","authenticated-orcid":false,"given":"Jonathan","family":"Van Hecke","sequence":"first","affiliation":[{"name":"Geneeskunde en Farmacie, Vrije Universiteit Brussel (VUB) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2701-9564","authenticated-orcid":false,"given":"Gigi","family":"Veereman","sequence":"additional","affiliation":[{"name":"Paediatric Gastroenterology, Hepatology and Nutrition, UZ Brussel, Vrije Universiteit Brussel (VUB) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6402-1762","authenticated-orcid":false,"given":"Koen","family":"Huysentruyt","sequence":"additional","affiliation":[{"name":"Paediatric Gastroenterology, Hepatology and Nutrition, UZ Brussel, Vrije Universiteit Brussel (VUB) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3195-4996","authenticated-orcid":false,"given":"Lucas","family":"Wauters","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, University Hospitals Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4857-6098","authenticated-orcid":false,"given":"Jeremy","family":"Adler","sequence":"additional","affiliation":[{"name":"Susan B. Meister Child Health Evaluation and Research Center, University of Michigan Ann Arbor Michigan USA"},{"name":"Division of Pediatric Gastroenterology, Michigan Medicine Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5534-7891","authenticated-orcid":false,"given":"Shehzad","family":"Saeed","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Boonshoft School of Medicine Wright State University, and Dayton Children's Hospital  Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1606-2033","authenticated-orcid":false,"given":"Elisabeth","family":"De Greef","sequence":"additional","affiliation":[{"name":"Paediatric Gastroenterology, Hepatology and Nutrition, UZ Brussel, Vrije Universiteit Brussel (VUB) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"and the ImproveCareNow Pediatric IBD Learning Health System","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1080\/1744666X.2021.1945442","article-title":"Improving prediction of disease outcome for inflammatory bowel disease: progress through systems medicine","volume":"17","author":"Giachero F","year":"2021","journal-title":"Expert Rev Clin Immunol"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.12688\/f1000research.20928.1","article-title":"Precision medicine in inflammatory bowel disease: concept, progress and challenges","volume":"9","author":"Borg\u2010Bartolo SP","year":"2020","journal-title":"F1000Research"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1016\/S0140-6736(18)32592-3","article-title":"Clinical and biological predictors of response to standardised paediatric colitis therapy (PROTECT): a multicentre inception cohort study","volume":"393","author":"Hyams JS","year":"2019","journal-title":"Lancet"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S2468-1253(17)30252-2","article-title":"Factors associated with early outcomes following standardised therapy in children with ulcerative colitis (PROTECT): a multicentre inception cohort study","volume":"2","author":"Hyams JS","year":"2017","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/apt.17544","article-title":"Validation of predictive models for disease outcomes in paediatric ulcerative colitis: a multicentre prospective inception cohort","volume":"58","author":"Atia O","year":"2023","journal-title":"Aliment Pharmacol Ther"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.3748\/wjg.v23.i18.3322","article-title":"Correlation of endoscopic disease severity with pediatric ulcerative colitis activity index score in children and young adults with ulcerative colitis","volume":"23","author":"Kerur B","year":"2017","journal-title":"World J Gastroenterol"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.3748\/wjg.v28.i28.3666","article-title":"How has the disease course of pediatric ulcerative colitis changed throughout the biologics era? 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