{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:33:39Z","timestamp":1793018019111,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JPGN rep."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Meconium ileus (MI) is a well\u2010recognised neonatal presentation of cystic fibrosis (CF) and is associated with a high nutritional risk. While nutritional management principles are outlined in international guidelines, there is limited literature describing the practical experiences of nutritional management. The aim of this communication was to describe nutritional factors observed during the first year of life in a series of MI\u2010CF infants. Data on nine surgically managed infants were reviewed from a UK CF centre. Timelines of (i) nutritional and surgical management and (ii) growth and intake outcomes are described. Findings highlight the heterogeneity of nutritional aspects in this group and the high prevalence of acute and chronic growth failure, further supporting the requirement for close nutritional monitoring. CFTR modulator therapies have revolutionised CF management and are increasingly available at younger ages. However, as treatment is initiated well after the neonatal period and acute MI, optimising nutritional management of MI\u2010CF infants remains a priority.<\/jats:p>","DOI":"10.1002\/jpr3.70254","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:48:47Z","timestamp":1792133327000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early nutritional management of cystic fibrosis infants born with meconium ileus"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8478-3923","authenticated-orcid":false,"given":"Laetitia","family":"Mouly","sequence":"first","affiliation":[{"name":"Brighton and Sussex Medical School University of Brighton and University of Sussex Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9925-5262","authenticated-orcid":false,"given":"Tom","family":"Ruffles","sequence":"additional","affiliation":[{"name":"Brighton and Sussex Medical School University of Brighton and University of Sussex Brighton UK"},{"name":"Royal Alexandra Children's Hospital University Hospitals Sussex NHS Foundation Trust Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8948-4741","authenticated-orcid":false,"given":"Chris","family":"Smith","sequence":"additional","affiliation":[{"name":"Brighton and Sussex Medical School University of Brighton and University of Sussex Brighton UK"},{"name":"Royal Alexandra Children's Hospital University Hospitals Sussex NHS Foundation Trust Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2023.12.017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2017.06.007"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-1993(21)01453-3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2021.02.047"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2019.07.003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2019.09.008"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.07.036"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2018.01.006"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2017.0206"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2023.12.002"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14111179"},{"key":"e_1_2_8_13_1","unstructured":"National Institute for Health and Care Excellence.Faltering Growth: Recognition and Management of Faltering Growth in Children (ng75). NICE; 2017.https:\/\/www.nice.org.uk\/guidance\/ng75"},{"issue":"1","key":"e_1_2_8_14_1","first-page":"32","article-title":"Meconium ileus in newborns with cystic fibrosis\u2212 results of treatment in the group of patients operated on in the years 2000\u20102014","volume":"19","author":"Boczar M","year":"2015","journal-title":"Dev Period Med"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13093263"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2024.07.006"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051500"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2022.09.001"},{"key":"e_1_2_8_19_1","unstructured":"National Institute for Health and Care Excellence.Ivacaftor\u2013Tezacaftor\u2013Elexacaftor Tezacaftor\u2013Ivacaftor and Lumacaftor\u2013Ivacaftor for Treating Cystic Fibrosis (ngta988). NICE; 2024.https:\/\/www.nice.org.uk\/guidance\/ta988"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2024.11.011"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2025.03.006"}],"container-title":["JPGN Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpr3.70254","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jpr3.70254","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpr3.70254","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T11:46:41Z","timestamp":1793015201000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpr3.70254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,15]]},"references-count":20,"alternative-id":["10.1002\/jpr3.70254"],"URL":"https:\/\/doi.org\/10.1002\/jpr3.70254","archive":["Portico"],"relation":{},"ISSN":["2691-171X","2691-171X"],"issn-type":[{"value":"2691-171X","type":"print"},{"value":"2691-171X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,15]]},"assertion":[{"value":"2026-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jpr3.70254"}}