{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:34:39Z","timestamp":1791070479192,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2002,9,1]],"date-time":"2002-09-01T00:00:00Z","timestamp":1030838400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2002,9]]},"DOI":"10.1002\/jps.10176","type":"journal-article","created":{"date-parts":[[2002,9,5]],"date-time":"2002-09-05T20:24:32Z","timestamp":1031257472000},"page":"1991-2002","source":"Crossref","is-referenced-by-count":198,"title":["A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P\u2010glycoprotein activity in vitro"],"prefix":"10.1016","volume":"91","author":[{"given":"Erin D.","family":"Hugger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara L.","family":"Novak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip S.","family":"Burton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth L.","family":"Audus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald T.","family":"Borchardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1002\/jps.10176_bb0010","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1146\/annurev.pharmtox.39.1.361","article-title":"Biochemical, cellular, and pharmacological aspects of the multidrug transporter","volume":"39","author":"Ambudkar","year":"1999","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1002\/jps.10176_bb0015","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0169-409X(97)00497-3","article-title":"Intestinal secretion of drugs: the role of P\u2010glycoprotein and related drug efflux systems in limiting oral drug absorption","volume":"25","author":"Hunter","year":"1997","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1002\/jps.10176_bb0020","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0169-409X(96)00415-2","article-title":"Caco\u20102 cell monolayers in experimental and theoretical predictions of drug transport","volume":"22","author":"Artursson","year":"1996","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1002\/jps.10176_bb0025","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/S0016-5085(89)80072-1","article-title":"Characterization of the human colon carcinoma cell line (Caco\u20102) as a model system for intestinal epithelial permeability","volume":"96","author":"Hidalgo","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1002\/jps.10176_bb0030","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1023\/A:1015937605100","article-title":"Caco\u20102 cell monolayers as a model for drug transport across the intestinal mucosa","volume":"7","author":"Hilgers","year":"1990","journal-title":"Pharm Res"},{"key":"10.1002\/jps.10176_bb0035","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1023\/A:1018972102702","article-title":"Drug absorption limited by P\u2010glycoprotein\u2010mediated secretory drug transport in human intestinal epithelial Caco\u20102 cell layers","volume":"10","author":"Hunter","year":"1993","journal-title":"Pharm Res"},{"key":"10.1002\/jps.10176_bb0040","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1021\/js970372e","article-title":"P\u2010glycoprotein (P\u2010gp) mediated efflux in Caco\u20102 cell monolayers: The influence of culturing conditions and drug exposure on P\u2010gp expression levels","volume":"87","author":"Anderle","year":"1998","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.10176_bb0045","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0006-2952(99)00133-1","article-title":"Transport of the flavenoid chrysin and its conjugated metabolites by the human intestinal cell line Caco\u20102","volume":"58","author":"Walle","year":"1999","journal-title":"Biochem Pharmacol"},{"key":"10.1002\/jps.10176_bb0050","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1023\/A:1015807904558","article-title":"The Madin Darby Canine Kidney (MDCK) epithelial cell monolayer as a model cellular transport barrier","volume":"6","author":"Cho","year":"1989","journal-title":"Pharm Res"},{"key":"10.1002\/jps.10176_bb0055","first-page":"F67","article-title":"Low permeabilities of MDCK cell monolayers: a model barrier epithelium","volume":"42","author":"Lavelle","year":"1997","journal-title":"Am J Physiol"},{"issue":"Suppl. 2","key":"10.1002\/jps.10176_bb0060","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1016\/S0928-0987(00)00164-0","article-title":"Cell cultures as tools in biopharmacy","volume":"11","author":"Braun","year":"2000","journal-title":"Eur J Pharm Sci"},{"key":"10.1002\/jps.10176_bb0065","doi-asserted-by":"crossref","first-page":"4486","DOI":"10.1073\/pnas.85.12.4486","article-title":"A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P\u2010glycoprotein in MDCK cells","volume":"85","author":"Pastan","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/jps.10176_bb0070","doi-asserted-by":"crossref","first-page":"14880","DOI":"10.1016\/S0021-9258(18)63784-6","article-title":"Transepithelial transport of drugs by the multidrug transporter in cultured Madin\u2010Darby canine kidney cell epithelia","volume":"264","author":"Horio","year":"1989","journal-title":"J Biol Chem"},{"key":"10.1002\/jps.10176_bb0075","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1021\/js9803205","article-title":"MDCK (Madin\u2010Darby canine kidney) cells: A tool for membrane permeability screening","volume":"88","author":"Irvine","year":"1999","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.10176_bb0080","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1002\/jps.10175","article-title":"Effects of poly(ethylene)glycol on efflux transporter activity in Caco\u20102 cell monolayers","volume":"91","author":"Hugger","year":"2001","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.10176_bb0085","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1023\/A:1016033702220","article-title":"The use of surfactants to enhance the permeability of peptides through Caco\u20102 cells by inhibition of an apically polarized efflux system","volume":"13","author":"Nerurkar","year":"1996","journal-title":"Pharm Res"},{"key":"10.1002\/jps.10176_bb0090","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1021\/js960483y","article-title":"Mechanistic roles of neutral surfactants on concurrent polarized and passive membrane transport of a model peptide in Caco\u20102 cells","volume":"86","author":"Nerurkar","year":"1997","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.10176_bb0095","series-title":"Current protocols in pharmacology","first-page":"1","article-title":"Estimating intestinal mucosal permeation of drugs using Caco\u20102 cell monolayers","author":"Gao","year":"2000"},{"key":"10.1002\/jps.10176_bb0100","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/1097-0215(200102)9999:9999<::AID-IJC1158>3.0.CO;2-8","article-title":"Cytostatic effect of polyethylene glycol on human colonic adenocarcinoma cells","volume":"92","author":"Parnaud","year":"2001","journal-title":"Int J Cancer"},{"key":"10.1002\/jps.10176_bb0105","first-page":"343","article-title":"Taxol transport by human intestinal epithelial Caco\u20102 cells","volume":"26","author":"Walle","year":"1998","journal-title":"Drug Metab Dispos"},{"key":"10.1002\/jps.10176_bb0110","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/jps.2600630403","article-title":"Mass transport phenomena and models: theoretical concepts","volume":"63","author":"Flynn","year":"1974","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.10176_bb0115","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/jps.2600840107","article-title":"A biophysical model of passive and polarized active transport processes in Caco\u20102 cells: Approaches to uncoupling apical and basolateral membrane events in the intact cell","volume":"84","author":"Ho","year":"1995","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.10176_bb0120","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0891-5849(91)90152-S","article-title":"Evidence for 21\u2010aminosteroid association with the hydrophobic domains of brain microvessel endothelial cells","volume":"11","author":"Audus","year":"1991","journal-title":"Free Radic Biol Med"},{"key":"10.1002\/jps.10176_bb0125","series-title":"Handbook of pharmaceutical excipients","first-page":"355","article-title":"Polyethylene glycol","author":"Price","year":"1994"},{"key":"10.1002\/jps.10176_bb0130","series-title":"Handbook of pharmaceutical excipients","first-page":"375","article-title":"Polyoxyethylene sorbitan fatty acid esters","author":"Leyland","year":"1994"},{"key":"10.1002\/jps.10176_bb0135","series-title":"Handbook of pharmaceutical excipients","first-page":"371","article-title":"Polyoxyethylene castor oil derivatives","author":"Yu","year":"1994"},{"key":"10.1002\/jps.10176_bb0140","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0378-5173(80)90059-9","article-title":"Histological and physiological studies on the intestine of the rat exposed to solutions of Mryj 52 and PEG 2000","volume":"7","author":"Bryan","year":"1980","journal-title":"Int J Pharm"},{"key":"10.1002\/jps.10176_bb0145","first-page":"902","article-title":"Effect of a dietary nonionic surfactant on small intestinal nutrient transport","volume":"7","author":"Donegan","year":"1990","journal-title":"Digest Dis"},{"key":"10.1002\/jps.10176_bb0150","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/1056-8719(94)00060-H","article-title":"Evaluation of mucosal damage of surfactants in rat jejunum and colon","volume":"33","author":"Oberle","year":"1995","journal-title":"J Pharmacol Toxicol Meth"},{"key":"10.1002\/jps.10176_bb0155","first-page":"4199","article-title":"Reversal of multidrug resistance phenotype with Cremophor EL, a common vehicle for water\u2010insoluble vitamins and drugs","volume":"50","author":"Woodcock","year":"1990","journal-title":"Cancer Res"},{"key":"10.1002\/jps.10176_bb0160","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/bjc.1992.217","article-title":"Reversal of multidrug resistance by surfactants","volume":"66","author":"Woodcock","year":"1992","journal-title":"Br J Cancer"},{"key":"10.1002\/jps.10176_bb0165","first-page":"5994","article-title":"Effects of nonionic detergents on P\u2010glycoprotein drug binding and reversal of multidrug resistance","volume":"53","author":"Zordan\u2010Nudo","year":"1993","journal-title":"Cancer Res"},{"key":"10.1002\/jps.10176_bb0170","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1006\/abbi.1995.1298","article-title":"Reversal of multidrug resistance related phenotype by surfactants: relationship to membrane fluidity","volume":"319","author":"Dudeja","year":"1995","journal-title":"Arch Biochem Biophys"},{"issue":"1","key":"10.1002\/jps.10176_bb0175","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0304-4157(75)90016-7","article-title":"Solubilization of membranes by detergents","volume":"415","author":"Helenius","year":"1975","journal-title":"Biochim Biophys Acta"},{"key":"10.1002\/jps.10176_bb0180","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1046\/j.1432-1327.2000.01046.x","article-title":"Analysis of tangled relationships between P\u2010glycoprotein\u2010mediated multidrug resistance and the lipid phase of the cell membrane","volume":"267","author":"Fert\u00e9","year":"2000","journal-title":"Eur J Biochem"},{"key":"10.1002\/jps.10176_bb0185","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0005-2736(93)90339-2","article-title":"The effects of lipids and detergents on ATPase\u2010active P\u2010glycoprotein","volume":"1146","author":"Doige","year":"1993","journal-title":"Biochim Biophys Acta"},{"key":"10.1002\/jps.10176_bb0190","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1023\/A:1015000503629","article-title":"Inhibition of P\u2010glycoprotein by D\u2010\u03b1\u2010tocopheryl polyethylene glycol 1000 succinate (TPGS)","volume":"16","author":"Dintaman","year":"1999","journal-title":"Pharm Res"},{"key":"10.1002\/jps.10176_bb0195","first-page":"245","article-title":"Inhibition of cytarabine\u2010induced MDR1 (P\u2010glycoprotein) gene activation in human tumor cells by fatty acid\u2010polyethylene glycol\u2010fatty acid diesters, novel inhibitors of P\u2010glycoprotein function. Int","volume":"68","author":"Komarov","year":"1996","journal-title":"J Cancer"},{"key":"10.1002\/jps.10176_bb0200","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1097\/00001813-199810000-00011","article-title":"Effect of cremophor EL and the pharmacokinetics, antitumor activity and toxicity of doxorubicin in mice","volume":"9","author":"Badary","year":"1998","journal-title":"Anti\u2010Cancer Drugs"},{"key":"10.1002\/jps.10176_bb0205","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1097\/00001813-199611000-00002","article-title":"Cremophor EL reverse mutidrug resistance in vitro but not in tumor\u2010bearing mouse models","volume":"7","author":"Watanabe","year":"1996","journal-title":"Anti\u2010Cancer Drugs"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354916310711?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354916310711?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T08:32:56Z","timestamp":1622104376000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354916310711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["S0022354916310711"],"URL":"https:\/\/doi.org\/10.1002\/jps.10176","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2002,9]]}}}