{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:53:23Z","timestamp":1758905603835},"reference-count":12,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2003,1]]},"DOI":"10.1002\/jps.10265","type":"journal-article","created":{"date-parts":[[2002,12,17]],"date-time":"2002-12-17T14:11:19Z","timestamp":1040134279000},"page":"21-26","source":"Crossref","is-referenced-by-count":22,"title":["Automated Analysis of Polyethylene Glycol-Induced Inhibition of P-Glycoprotein Activity In Vitro"],"prefix":"10.1016","volume":"92","author":[{"given":"Erin D.","family":"Hugger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clayton J.","family":"Cole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Raub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip S.","family":"Burton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald T.","family":"Borchardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1002\/jps.10265_bb0010","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1023\/A:1016033702220","article-title":"The use of surfactants to enhance the permeability of peptides through Caco-2 cells by inhibition of an apically polarized efflux system","volume":"13","author":"Nerurkar","year":"1996","journal-title":"Pharm Res"},{"key":"10.1002\/jps.10265_bb0015","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1021\/js960483y","article-title":"Mechanistic roles of neutral surfactants on concurrent polarized and passive membrane transport of a model peptide in Caco-2 cells","volume":"86","author":"Nerurkar","year":"1997","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.10265_bb0020","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1002\/jps.10175","article-title":"Effects of polyethylene glycol on efflux transporter activity in Caco-2 cell monolayers","volume":"91","author":"Hugger","year":"2002","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.10265_bb0025","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1002\/jps.10176","article-title":"A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P-glycoprotein activity in vitro","volume":"91","author":"Hugger","year":"2002","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.10265_bb0030","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1146\/annurev.pharmtox.39.1.361","article-title":"Biochemical, cellular, and pharmacological aspects of the multidrug transporter","volume":"39","author":"Ambudkar","year":"1999","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1002\/jps.10265_bb0035","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1177\/38.9.1974900","article-title":"Expression of the multidrug resistance gene product (P-glycoprotein) in human and normal tissues","volume":"38","author":"Cordon-Cardo","year":"1990","journal-title":"J Histochem Cytochem"},{"key":"10.1002\/jps.10265_bb0040","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0169-409X(97)00497-3","article-title":"Intestinal secretion of drugs: The role of P-glycoprotein and related drug efflux systems in limiting oral drug absorption","volume":"25","author":"Hunter","year":"1997","journal-title":"Adv Drug Delivery Rev"},{"key":"10.1002\/jps.10265_bb0045","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1023\/A:1018972102702","article-title":"Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal Caco-2 cell monolayers","volume":"10","author":"Hunter","year":"1993","journal-title":"Pharm Res"},{"key":"10.1002\/jps.10265_bb0050","doi-asserted-by":"crossref","first-page":"69","DOI":"10.5414\/CPP38069","article-title":"P-glycoprotein: A defense mechanism limiting oral bioavailability and CNS accumulation of drugs","volume":"38","author":"Fromm","year":"2000","journal-title":"Int J Clin Pharmacol Ther"},{"key":"10.1002\/jps.10265_bb0055","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1006\/bbrc.1993.1114","article-title":"Evidence for a polarized efflux system for peptides in the apical membrane of Caco-2 cells","volume":"190","author":"Burton","year":"1993","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1002\/jps.10265_bb0060","series-title":"Current protocols in pharmacology","first-page":"1","article-title":"Estimating intestinal mucosal permeation of drugs using Caco-2 cell monolayers","author":"Gao","year":"2000"},{"key":"10.1002\/jps.10265_bb0065","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/S0016-5085(89)80072-1","article-title":"Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability","volume":"96","author":"Hidalgo","year":"1989","journal-title":"Gastroenterology"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354916311455?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354916311455?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,31]],"date-time":"2019-03-31T16:28:10Z","timestamp":1554049690000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354916311455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["S0022354916311455"],"URL":"https:\/\/doi.org\/10.1002\/jps.10265","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2003,1]]}}}