{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:38:14Z","timestamp":1790339894353,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2003,6,1]],"date-time":"2003-06-01T00:00:00Z","timestamp":1054425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2003,6]]},"DOI":"10.1002\/jps.10370","type":"journal-article","created":{"date-parts":[[2003,5,19]],"date-time":"2003-05-19T11:35:17Z","timestamp":1053344117000},"page":"1138-1146","source":"Crossref","is-referenced-by-count":74,"title":["Skin Permeability Enhancement by Low Frequency Sonophoresis: Lipid Extraction and Transport Pathways"],"prefix":"10.1016","volume":"92","author":[{"given":"R.","family":"Alvarez\u2010Rom\u00e1n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Merino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.N.","family":"Kalia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Naik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.H.","family":"Guy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1002\/jps.10370_bb0010","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1023\/A:1016096626810","article-title":"Transdermal drug delivery using low frequency sonophoresis","volume":"3","author":"Mitragotri","year":"1996","journal-title":"Pharm Res"},{"key":"10.1002\/jps.10370_bb0015","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0168-3659(95)00087-9","article-title":"Skin penetration\u2010enhancing effect of drugs by sonophoresis","volume":"37","author":"Ueda","year":"1995","journal-title":"J Controlled Release"},{"key":"10.1002\/jps.10370_bb0020","series-title":"Development issues and research initiatives","first-page":"23","article-title":"Stratum corneum: Biological and biochemical considerations. Transdermal drug delivery","author":"Walters","year":"1989"},{"key":"10.1002\/jps.10370_bb0025","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1073\/pnas.87.10.3871","article-title":"Lipid biophysics of water loss through the skin","volume":"87","author":"Potts","year":"1990","journal-title":"Proc Natl Acad Sci"},{"key":"10.1002\/jps.10370_bb0030","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1023\/A:1015822312426","article-title":"Oleic acid: Its effects on stratum corneum in relation to (trans)dermal drug delivery","volume":"7","author":"Francoeur","year":"1990","journal-title":"Pharm Res"},{"key":"10.1002\/jps.10370_bb0035","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0168-3659(91)90116-U","article-title":"Mechanism and enhancement of solute transport across the stratum corneum","volume":"15","author":"Potts","year":"1991","journal-title":"J Controlled Release"},{"key":"10.1002\/jps.10370_bb0040","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/1523-1747.ep12285373","article-title":"Lipid thermotropic transitions in human stratum corneum","volume":"86","author":"Golden","year":"1986","journal-title":"J Invest Dermatol"},{"key":"10.1002\/jps.10370_bb0045","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/1523-1747.ep12393214","article-title":"Characterization of low\u2010temperature (i.e., <65\u00b0C) lipid transitions in human stratum corneum","volume":"103","author":"Gay","year":"1994","journal-title":"J Invest Dermatol"},{"key":"10.1002\/jps.10370_bb0050","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/(SICI)1520-6017(200006)89:6<771::AID-JPS9>3.0.CO;2-Y","article-title":"Mechanism(s) of in vitro percutaneous absorption enhancement of tamoxifen by enhancers","volume":"89","author":"Zhao","year":"2000","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.10370_bb0055","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0378-5173(00)00697-9","article-title":"Lipid extraction and iontophoretic transport of leuprolide acetate through porcine epidermis","volume":"215","author":"Rastogi","year":"2001","journal-title":"Int J Pharm"},{"key":"10.1002\/jps.10370_bb0060","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0378-5173(01)00766-9","article-title":"Lipid extraction and transport of hydrophilic solutes through porcine epidermis","volume":"225","author":"Rastogi","year":"2001","journal-title":"Int J Pharm"},{"key":"10.1002\/jps.10370_bb0065","series-title":"Mechanisms of transdermal drug delivery","first-page":"87","article-title":"Infrared spectroscopic and differential scanning calorimetric investigations of the stratum corneum barrier function","author":"Naik","year":"1997"},{"key":"10.1002\/jps.10370_bb0070","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1023\/A:1011906022903","article-title":"Mechanism of transport enhancement of LHRH through porcine epidermis by terpenes and iontophoresis: Permeability and lipid extraction studies","volume":"15","author":"Bhatia","year":"1998","journal-title":"Pharm Res"},{"key":"10.1002\/jps.10370_bb0075","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1021\/js960020s","article-title":"Imaging regions of transport across human stratum corneum during high\u2010voltage and low\u2010voltage exposures","volume":"85","author":"Prausnitz","year":"1996","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.10370_bb0080","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1023\/A:1012100100865","article-title":"Iontophoresis of poly\u2010L\u2010lysines: The role of molecular weight?","volume":"14","author":"Turner","year":"1997","journal-title":"Pharm Res"},{"key":"10.1002\/jps.10370_bb0085","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1021\/js970046z","article-title":"Iontophoretic transport pathways: Dependence on penetrant physicochemical properties","volume":"86","author":"Turner","year":"1997","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.10370_bb0090","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/jidsymp.1998.28","article-title":"Visualization and quantitation of iontophoretic pathways using confocal microscopy","volume":"3","author":"Turner","year":"1998","journal-title":"J Invest Dermatol Symp Proc"},{"key":"10.1002\/jps.10370_bb0095","doi-asserted-by":"crossref","unstructured":"Merino G, Kalia YN, Delgado-Charro MB, Potts RO, Guy RH. Frequency and thermal effects on the enhancement of transdermal transport by sonophoresis. J Controlled Release, in press.","DOI":"10.1016\/S0168-3659(02)00464-9"},{"key":"10.1002\/jps.10370_bb0100","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/jps.2600840607","article-title":"A mechanistic study of ultrasonically\u2010enhanced transdermal drug delivery","volume":"84","author":"Mitragotri","year":"1995","journal-title":"J Pham Sci"},{"key":"10.1002\/jps.10370_bb0105","first-page":"437","article-title":"Influence of ultrasonic parameters on low\u2010frequency sonophoresis","volume":"26","author":"Terahara","year":"1999","journal-title":"Proceed Intl Symp Controlled Release Bioact Mater"},{"key":"10.1002\/jps.10370_bb0110","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/0005-2760(87)90290-6","article-title":"Covalently bound \u03c9\u2010hydroxylsphingosine in the stratum corneum","volume":"917","author":"Wertz","year":"1987","journal-title":"Biochim Biophys Acta"},{"key":"10.1002\/jps.10370_bb0115","series-title":"Internal reflection spectroscopy","author":"Mirabella","year":"1993"},{"key":"10.1002\/jps.10370_bb0120","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0168-3659(99)00178-9","article-title":"Determination of threshold energy dose for ultrasound\u2010induced transdermal drug transport","volume":"63","author":"Mitragotri","year":"2000","journal-title":"J Controlled Release"},{"key":"10.1002\/jps.10370_bb0125","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1002\/1520-6017(200009)89:9<1170::AID-JPS9>3.0.CO;2-9","article-title":"Transdermal extraction of interstitial fluid by low\u2010frequency ultrasound quantified with 3H2O as a tracer molecule","volume":"89","author":"Cantrell","year":"2000","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.10370_bb0130","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1023\/A:1015806528336","article-title":"Sonophoresis II. Examination of the mechanisms of ultrasound\u2010enhanced transdermal drug delivery","volume":"9","author":"Bommanan","year":"1992","journal-title":"Pharm Res"},{"key":"10.1002\/jps.10370_bb0135","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1023\/A:1013366328457","article-title":"Frequency dependence of sonophoresis","volume":"18","author":"Tezel","year":"2001","journal-title":"Pharm Res"},{"key":"10.1002\/jps.10370_bb0140","series-title":"Ultrasound its chemical, physical, and biological effect","first-page":"305","article-title":"Biological effects of ultrasound in clinical applications","author":"Ter Haar","year":"1988"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354916312643?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354916312643?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T12:21:22Z","timestamp":1553170882000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354916312643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2003,6]]}},"alternative-id":["S0022354916312643"],"URL":"https:\/\/doi.org\/10.1002\/jps.10370","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2003,6]]}}}