{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T01:10:33Z","timestamp":1726017033399},"reference-count":24,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2001,12,1]],"date-time":"2001-12-01T00:00:00Z","timestamp":1007164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2001,12]]},"DOI":"10.1002\/jps.1159","type":"journal-article","created":{"date-parts":[[2003,3,28]],"date-time":"2003-03-28T21:56:41Z","timestamp":1048888601000},"page":"2088-2098","source":"Crossref","is-referenced-by-count":20,"title":["Microdialysis studies of the middle ear distribution kinetics of amoxicillin in the awake chinchilla"],"prefix":"10.1016","volume":"90","author":[{"given":"Yue","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Inano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.Scott","family":"Giebink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald J.","family":"Sawchuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1002\/jps.1159_bb0010","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0022-3476(05)82074-8","article-title":"Antimicrobial treatment of acute otitis media","volume":"119","author":"Giebink","year":"1991","journal-title":"J Pediatr"},{"issue":"Part 2 Suppl","key":"10.1002\/jps.1159_bb0015","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1177\/00034894941030S504","article-title":"Antimicrobial treatment of acute otitis media","volume":"103","author":"Canafax","year":"1994","journal-title":"Ann Oto Rhino Laryngol"},{"key":"10.1002\/jps.1159_bb0020","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S0030-6665(20)31096-3","article-title":"Clinical and pharmacokinetic basis for the antimicrobial treatment of acute otitis media","volume":"24","author":"Canafax","year":"1991","journal-title":"Otolaryngol Clin of N Am"},{"key":"10.1002\/jps.1159_bb0025","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1128\/AAC.35.10.1953","article-title":"Antibiotic tissue penetration and its relevance: Impact of tissue penetration on infection response","volume":"35","author":"Nix","year":"1991","journal-title":"Antimicrob Agents Chemother"},{"issue":"Suppl","key":"10.1002\/jps.1159_bb0030","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/jac\/15.suppl_A.59","article-title":"General principles of antibiotic tissue penetration","volume":"15","author":"Barza","year":"1985","journal-title":"J Antimicrob Chemother"},{"key":"10.1002\/jps.1159_bb0035","series-title":"PD and drug development: Perspectives in clinical pharmacology","first-page":"315","article-title":"Antibiotic PD","author":"Rotschafer","year":"1994"},{"key":"10.1002\/jps.1159_bb0040","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1097\/00006454-199610000-00032","article-title":"PK and PD of antibiotics in otitis media","volume":"15","author":"Craig","year":"1996","journal-title":"Pediatr Infect Dis J"},{"key":"10.1002\/jps.1159_bb0045","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1097\/00006454-199811000-00037","article-title":"PK and PD of new and old antimicrobial agents for acute otitis media","volume":"17","author":"Blumer","year":"1998","journal-title":"Pediatr Infect Dis J"},{"key":"10.1002\/jps.1159_bb0050","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1093\/ajhp\/55.18.1881","article-title":"Otitis media: Focus on antimicrobial resistance and new treatment options","volume":"55","author":"Hoppe","year":"1998","journal-title":"Am J Health\u2010Syst Pharm"},{"key":"10.1002\/jps.1159_bb0055","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/00006454-199802000-00014","article-title":"Amoxicillin middle ear penetration and PK in children with acute otitis media","volume":"17","author":"Canafax","year":"1998","journal-title":"Pediatr Infect Dis J"},{"key":"10.1002\/jps.1159_bb0060","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1023\/A:1012081501464","article-title":"Application of microdialysis in PK","volume":"14","author":"Elmquist","year":"1997","journal-title":"Pharm Res"},{"key":"10.1002\/jps.1159_bb0065","series-title":"Techniques in the Behavioral and Neural Sciences","article-title":"Microdialysis in the Neurosciences","author":"Robinson","year":"1991"},{"key":"10.1002\/jps.1159_bb0070","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1023\/A:1015977603224","article-title":"An experimental model for measuring middle ear antimicrobial drug penetration in otitis media","volume":"7","author":"Jossart","year":"1990","journal-title":"Pharm Res"},{"key":"10.1002\/jps.1159_bb0075","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0196-0709(87)80035-2","article-title":"Anatomy of the chinchilla bulla and Eustachian tube: I. Gross and microscopic study","volume":"3","author":"Hanamure","year":"1987","journal-title":"Am J Otolaryngol"},{"key":"10.1002\/jps.1159_bb0080","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1023\/A:1018921906993","article-title":"Investigation of the distribution of EAB515 to cortical ECF and CSF in freely moving rats utilizing microdialysis","volume":"11","author":"Malhotra","year":"1994","journal-title":"Pharm Res"},{"key":"10.1002\/jps.1159_bb0085","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1023\/A:1012191515035","article-title":"Microdialysis studies of the distribution of stavudine into the central nervous system in the freely\u2010moving rat","volume":"14","author":"Yang","year":"1997","journal-title":"Pharm Res"},{"key":"10.1002\/jps.1159_bb0090","unstructured":"Brundage RC. Ph.D. Thesis, Investigation of the brain distribution and pre\u2010systemic metabolism of tacrine and selected metabolites using microdialysis of brain and blood. University of Minnesota, 1996."},{"key":"10.1002\/jps.1159_bb0095","unstructured":"Yang Z. Ph.D. Thesis, Pharmacokinetic studies of antiviral nucleosides: Brain distribution, intestinal absorption, and nasal delivery. University of Minnesota, 1997."},{"key":"10.1002\/jps.1159_bb0100","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0378-4347(96)00529-4","article-title":"HPLC analysis of amoxicillin in human and chinchilla plasma, middle ear fluid and whole blood","volume":"692","author":"Yuan","year":"1997","journal-title":"J Chromatogr B, Biomed Appl"},{"key":"10.1002\/jps.1159_bb0105","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1023\/A:1018906821725","article-title":"Microdialysis calibration using retrodialysis and zero\u2010net flux: Application to a study of the distribution of zidovudine to rabbit cerebrospinal fluid and thalamus","volume":"10","author":"Wang","year":"1993","journal-title":"Pharm Res"},{"key":"10.1002\/jps.1159_bb0110","first-page":"899","article-title":"Distributional transport kinetics of zidovudine between plasma and brain extracellular fluid\/cerebrospinal fluid in the rabbit: Investigation of the inhibitory effect of probenecid utilizing microdialysis","volume":"264","author":"Wong","year":"1993","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1002\/jps.1159_bb0115","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1023\/A:1015938205892","article-title":"Experimental animal models for studying antimicrobial PK in otitis media","volume":"6","author":"Canafax","year":"1989","journal-title":"Pharm Res"},{"key":"10.1002\/jps.1159_bb0120","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1093\/jac\/12.3.273","article-title":"Amoxicillin\/clavulanic acid: The effect of probenecid","volume":"12","author":"Staniforth","year":"1983","journal-title":"J Antimicrob Chemother"},{"key":"10.1002\/jps.1159_bb0125","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/cpt196893345","article-title":"The apparent effect of probenecid on the distribution of penicillin in man","volume":"9","author":"Gibaldi","year":"1968","journal-title":"Clin Pharmacol Ther"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354916305287?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354916305287?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,2]],"date-time":"2021-05-02T21:53:33Z","timestamp":1619992413000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354916305287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12]]},"references-count":24,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2001,12]]}},"alternative-id":["S0022354916305287"],"URL":"https:\/\/doi.org\/10.1002\/jps.1159","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2001,12]]}}}