{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:51:14Z","timestamp":1791481874089,"version":"4.3.4"},"reference-count":20,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2004,4]]},"DOI":"10.1002\/jps.20017","type":"journal-article","created":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T08:00:41Z","timestamp":1078128041000},"page":"877-885","source":"Crossref","is-referenced-by-count":146,"title":["Modulation of Intestinal P-Glycoprotein Function by Cremophor EL and Other Surfactants by an In Vitro Diffusion Chamber Method Using the Isolated Rat Intestinal Membranes"],"prefix":"10.1016","volume":"93","author":[{"given":"Yasushi","family":"Shono","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisayo","family":"Nishihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiori","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Okada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1002\/jps.20017_bb0010","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0169-409X(97)00497-3","article-title":"Intestinal secretion of drugs: The role of P-glycoprotein and related drug efflux systems in limiting oral drug absorption","volume":"25","author":"Hunter","year":"1997","journal-title":"Adv Drug Del Rev"},{"key":"10.1002\/jps.20017_bb0015","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/j.2042-7158.1996.tb05904.x","article-title":"Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier","volume":"48","author":"Terao","year":"1996","journal-title":"J Pharm Pharmacol"},{"key":"10.1002\/jps.20017_bb0020","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1021\/js970294v","article-title":"Role of P-glycoprotein as a secretory mechanism in quinidine absorption from rat small intestine","volume":"87","author":"Emi","year":"1998","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.20017_bb0025","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1016\/S0169-409X(01)00183-1","article-title":"Intestinal drug efflux: formulation and food effect","volume":"50","author":"Wagner","year":"2001","journal-title":"Adv Drug Del Rev"},{"key":"10.1002\/jps.20017_bb0030","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1023\/A:1016033702220","article-title":"The use of surfactants to enhance the permeability of peptides through Caco-2 cells by inhibition of an apically polarized efflux system","volume":"13","author":"Nururkar","year":"1996","journal-title":"Pharm Res"},{"key":"10.1002\/jps.20017_bb0035","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1021\/js960483y","article-title":"Mechanistic roles of neutral surfactants on concurrent polarized and passive membrane transport of a model peptide in Caco-2 cell","volume":"86","author":"Nerurkar","year":"1997","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.20017_bb0040","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0928-0987(02)00055-6","article-title":"Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers","volume":"16","author":"Rege","year":"2002","journal-title":"Eur J Pharm Sci"},{"key":"10.1002\/jps.20017_bb0045","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1002\/jps.10175","article-title":"Effects of poly(ethylene glycol) on efflux transporter activity in Caco-2 cell monolayers","volume":"91","author":"Hugger","year":"2002","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.20017_bb0050","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1002\/jps.10176","article-title":"A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P-glycoprotein activity in vitro","volume":"91","author":"Hugger","year":"2002","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.20017_bb0055","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1021\/js970372e","article-title":"P-glycoprotein (P-gp) mediated efflux in Caco-2 cell monolayers: The influence of culturing condition and drug exposure on P-gp expression levels","volume":"87","author":"Anderle","year":"1998","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.20017_bb0060","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1023\/A:1016005212640","article-title":"Age-dependent expression of P-glycoprotein, gp170 in Caco-2 cell monolayers","volume":"13","author":"Hosoya","year":"1996","journal-title":"Pharm Res"},{"key":"10.1002\/jps.20017_bb0065","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1023\/A:1015911712079","article-title":"In vitro measurement of gastrointestinal tissue permeability using a new diffusion cell","volume":"5","author":"Grass","year":"1988","journal-title":"Pharm Res"},{"key":"10.1002\/jps.20017_bb0070","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/0024-3205(96)00483-3","article-title":"Use of rhodamine123 to examine the functional activity of P-glycoprotein in primary cultured brain microvessel endothelial cell monolayers","volume":"59","author":"Fontaine","year":"1996","journal-title":"Life Sci"},{"key":"10.1002\/jps.20017_bb0075","first-page":"149","article-title":"Transport of rhodamine123, a P-glycoprotein substrate, across rat intestine and Caco-2 cell monolayers in the presence of cytochrome P-450 3A-related compounds","volume":"289","author":"Yumoto","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1002\/jps.20017_bb0080","first-page":"4199","article-title":"Reversal of the multidrug resistance phenotype with Cremophor EL, a common vehicle for water-insoluble vitamins and drugs","volume":"50","author":"Woodcock","year":"1990","journal-title":"Cancer Res"},{"key":"10.1002\/jps.20017_bb0085","first-page":"5994","article-title":"Effects of nonionic detergents on P-glycoportein drug binding and reversal of multidrug resistance","volume":"53","author":"Zordan-Nudo","year":"1993","journal-title":"Cancer Res"},{"key":"10.1002\/jps.20017_bb0090","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0378-5173(92)90107-D","article-title":"Assessment of enhancing ability of medium-chain alkylsaccharides as new absorption enhancers in rat rectum","volume":"79","author":"Murakami","year":"1992","journal-title":"Int J Pharm"},{"key":"10.1002\/jps.20017_bb0095","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1211\/0022357991776976","article-title":"Enhanced permeability of insulin across the rat intestinal membrane by various absorption enhancers: Their intestinal mucosal toxicity and absorption-enhancing mechanism of n-lauryl-\u03b2-D-maltopyranoside","volume":"51","author":"Uchiyama","year":"1999","journal-title":"J Pharm Pharmacol"},{"key":"10.1002\/jps.20017_bb0100","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1006\/abbi.1995.1298","article-title":"Reversal of multidrug resistance to membrane lipid fluidity","volume":"319","author":"Dudeja","year":"1995","journal-title":"Arch Biochem Biophys"},{"key":"10.1002\/jps.20017_bb0105","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/S0006-2952(99)00288-9","article-title":"Mechanism of inhibition of P-glycoprotein-mediated drug transport by protein kinase C blockers","volume":"58","author":"Castro","year":"1999","journal-title":"Biochem Pharmacol"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354916314794?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354916314794?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T21:59:23Z","timestamp":1550181563000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354916314794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["S0022354916314794"],"URL":"https:\/\/doi.org\/10.1002\/jps.20017","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2004,4]]}}}