{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:40:57Z","timestamp":1790710857374,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2005,4]]},"DOI":"10.1002\/jps.20285","type":"journal-article","created":{"date-parts":[[2005,1,29]],"date-time":"2005-01-29T07:25:44Z","timestamp":1106983544000},"page":"701-708","source":"Crossref","is-referenced-by-count":84,"title":["Contribution of ROCK in Contraction of Trabecular Meshwork: Proposed Mechanism for Regulating Aqueous Outflow in Monkey and Human Eyes"],"prefix":"10.1016","volume":"94","author":[{"given":"Emi","family":"Nakajima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Minagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Shearer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuyoshi","family":"Azuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1002\/jps.20285_bb0010","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S1094-9194(01)00004-4","article-title":"Intraocular pressure and glaucoma","volume":"5","author":"Ofri","year":"2002","journal-title":"Vet Clin North Am Exot Anim Pract"},{"key":"10.1002\/jps.20285_bb0015","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1021\/jm9608725","article-title":"New approaches to antiglaucoma therapy","volume":"40","author":"Sugrue","year":"1997","journal-title":"J Med Chem"},{"key":"10.1002\/jps.20285_bb0020","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S1350-9462(99)00015-4","article-title":"The regulation of trabecular meshwork and ciliary muscle contractility","volume":"19","author":"Wiederholt","year":"2000","journal-title":"Prog Retin Eye Res"},{"key":"10.1002\/jps.20285_bb0025","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/00055735-199804000-00009","article-title":"Direct involvement of trabecular meshwork in the regulation of aqueous humor outflow","volume":"9","author":"Wiederholt","year":"1998","journal-title":"Curr Opin Ophthalmol"},{"key":"10.1002\/jps.20285_bb0030","first-page":"1012","article-title":"Role of protein tyrosine kinase on regulation of trabecular meshwork and ciliary muscle contractility","volume":"39","author":"Wiederholt","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1002\/jps.20285_bb0035","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0014-4835(91)90141-Z","article-title":"Differential smooth muscle-like contractile properties of trabecular meshwork and ciliary muscle","volume":"53","author":"Lepple-Wienhues","year":"1991","journal-title":"Exp Eye Res"},{"key":"10.1002\/jps.20285_bb0040","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/372231a0","article-title":"Signal transduction and regulation in smooth muscle","volume":"372","author":"Somlyo","year":"1994","journal-title":"Nature"},{"key":"10.1002\/jps.20285_bb0045","doi-asserted-by":"crossref","first-page":"20246","DOI":"10.1074\/jbc.271.34.20246","article-title":"Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)","volume":"271","author":"Amano","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1002\/jps.20285_bb0050","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1126\/science.273.5272.245","article-title":"Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)","volume":"273","author":"Kimura","year":"1996","journal-title":"Science"},{"key":"10.1002\/jps.20285_bb0055","doi-asserted-by":"crossref","first-page":"12257","DOI":"10.1074\/jbc.272.19.12257","article-title":"Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation","volume":"272","author":"Kureishi","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1002\/jps.20285_bb0060","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1001\/archopht.116.5.633","article-title":"H-7 disrupts the actin cytoskeleton and increases outflow facility","volume":"116","author":"Tian","year":"1998","journal-title":"Arch Ophthalmol"},{"key":"10.1002\/jps.20285_bb0065","first-page":"145","article-title":"Effect of H-7 on cultured trabecular meshwork cells","volume":"7","author":"Liu","year":"2001","journal-title":"Mol Vis"},{"key":"10.1002\/jps.20285_bb0070","first-page":"955","article-title":"H-7 effects on the structure and fluid conductance of monkey trabecular meshwork","volume":"118","author":"Sabanay","year":"2000","journal-title":"Arch Ophthalmol"},{"key":"10.1002\/jps.20285_bb0075","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1076\/ceyr.22.6.470.5489","article-title":"Reduction of intraocular pressure by topical administration of an inhibitor of the Rho-associated protein kinase","volume":"22","author":"Waki","year":"2001","journal-title":"Curr Eye Res"},{"key":"10.1002\/jps.20285_bb0080","first-page":"137","article-title":"Effects of rho-associated protein kinase inhibitor Y-27632 on intraocular pressure and outflow facility","volume":"42","author":"Honjo","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1002\/jps.20285_bb0085","first-page":"1191","article-title":"ROCK inhibitor and glaucoma","volume":"17","author":"Tokushige","year":"2002","journal-title":"Bio Clinica"},{"key":"10.1002\/jps.20285_bb0090","first-page":"4240","article-title":"Mediation of calcium-independent contraction in trabecular meshwork through protein kinase C and rho-A","volume":"41","author":"Thieme","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1002\/jps.20285_bb0095","first-page":"1029","article-title":"Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632","volume":"42","author":"Rao","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1002\/jps.20285_bb0100","article-title":"Effect of Rho kinase inhibitor Y-27632 and the phosphatase inhibitor calyculin A on outflow facility in monkeys","author":"Tian","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1002\/jps.20285_bb0105","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0014-4835(05)90001-8","article-title":"The effect of topical PGF2\u03b1 on uveoscleral outflow and outflow facility in the rabbit eye","volume":"54","author":"Poyer","year":"1992","journal-title":"Exp Eye Res"},{"key":"10.1002\/jps.20285_bb0110","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1006\/bbrc.2001.5751","article-title":"Involvement of phosphorylation of myosin phosphatase by ROCK in trabecular meshwork and ciliary muscle contraction","volume":"288","author":"Fukiage","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1002\/jps.20285_bb0115","first-page":"323","article-title":"Water-soluble eumelanin as a PCR-inhibitor and a simple method for its removal","volume":"47","author":"Yoshii","year":"1993","journal-title":"Jpn J Leg Med"},{"key":"10.1002\/jps.20285_bb0120","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1093\/bioinformatics\/18.12.1585","article-title":"Robust estimators for expression analysis","volume":"12","author":"Hubbell","year":"2002","journal-title":"Bioinformatics"},{"key":"10.1002\/jps.20285_bb0125","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1124\/mol.61.6.1267","article-title":"Quantitation of mRNAs for M(1) to M(5) subtypes of muscarinic receptors in rat heart and brain cortex","volume":"61","author":"Krejci","year":"2002","journal-title":"Mol Pharmacol"},{"issue":"pt 1","key":"10.1002\/jps.20285_bb0130","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1042\/bj20021274","article-title":"Differential Signaling by Muscarinic Receptors in Smooth Muscle: m2-mediated inactivation of MLCK via Gi3, Cdc42\/Rac1, and PAK1, and m3-mediated MLC20 phosphorylation via Rho kinase\/MYPT1 and PKC\/CPI-17 pathways","volume":"374","author":"Murthy","year":"2003","journal-title":"Biochem J"},{"key":"10.1002\/jps.20285_bb0135","doi-asserted-by":"crossref","first-page":"R496","DOI":"10.1016\/S0960-9822(02)00968-5","article-title":"Gem GTPase: Between a ROCK and a hard place","volume":"12","author":"Olson","year":"2002","journal-title":"Curr Biol"},{"key":"10.1002\/jps.20285_bb0140","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/eye.1997.43","article-title":"The uveoscleral outflow routes","volume":"11","author":"Nilsson","year":"1997","journal-title":"Eye"},{"key":"10.1002\/jps.20285_bb0145","first-page":"1134","article-title":"From PGF2\u03b1-isopropyl ester to latanoprost: A review of the development of xalatan: The Proctor Lecture","volume":"42","author":"Stjernschantz","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1002\/jps.20285_bb0150","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1001\/archopht.116.8.1070","article-title":"Effect of H-7 on the iris and ciliary muscle in monkeys","volume":"116","author":"Tian","year":"1998","journal-title":"Arch Ophthalmol"},{"key":"10.1002\/jps.20285_bb0155","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3928\/1542-8877-20030501-19","article-title":"Scanning laser Doppler flowmetry of nonperfused regions of the optic nerve head in patients with glaucoma","volume":"34","author":"Ben Simon","year":"2003","journal-title":"Ophthalmic Surg Lasers Imaging"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354916317427?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354916317427?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,5]],"date-time":"2020-04-05T13:30:51Z","timestamp":1586093451000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354916317427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["S0022354916317427"],"URL":"https:\/\/doi.org\/10.1002\/jps.20285","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2005,4]]}}}