{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:21:10Z","timestamp":1791138070479,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2006,11]]},"DOI":"10.1002\/jps.20694","type":"journal-article","created":{"date-parts":[[2006,8,2]],"date-time":"2006-08-02T20:22:18Z","timestamp":1154550138000},"page":"2438-2451","source":"Crossref","is-referenced-by-count":57,"title":["Ultra-Fast Absorption of Amorphous Pure Drug Aerosols via Deep Lung Inhalation"],"prefix":"10.1016","volume":"95","author":[{"given":"Joshua D.","family":"Rabinowitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"Lloyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik","family":"Munzar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Myers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Cross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Damani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reynaldo","family":"Quintana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Spyker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pravin","family":"Soni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James V.","family":"Cassella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1002\/jps.20694_bb0010","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/BF01062110","article-title":"Effect of route of administration and distribution on drug action","volume":"6","author":"Benet","year":"1978","journal-title":"J Pharmacokinet Biopharm"},{"key":"10.1002\/jps.20694_bb0015","first-page":"92","article-title":"Cardiac output measurement by indicator dilution","volume":"10","author":"Chamberlain","year":"1975","journal-title":"Biomed Eng"},{"key":"10.1002\/jps.20694_bb0020","doi-asserted-by":"crossref","first-page":"175","DOI":"10.2165\/00003088-198917030-00004","article-title":"The phenomenon and rationale of marked dependence of drug concentration on blood sampling site. Implications in pharmacokinetics, pharmacodynamics, toxicology and therapeutics (Part I)","volume":"17","author":"Chiou","year":"1989","journal-title":"Clin Pharmacokinet"},{"key":"10.1002\/jps.20694_bb0025","first-page":"445","article-title":"Adenosine as a therapeutic agent","volume":"15","author":"Mosqueda-Garcia","year":"1992","journal-title":"Clin Invest Med"},{"key":"10.1002\/jps.20694_bb0030","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1526-4610.2004.04030.x","article-title":"Onset of effect of 5-HT1B\/1D agonists: A model with pharmacokinetic validation","volume":"44","author":"Fox","year":"2004","journal-title":"Headache"},{"key":"10.1002\/jps.20694_bb0035","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1136\/thx.50.6.639","article-title":"Aerosol deposition in the human lung following administration from a microprocessor controlled pressurised metered dose inhaler","volume":"50","author":"Farr","year":"1995","journal-title":"Thorax"},{"key":"10.1002\/jps.20694_bb0040","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1089\/jam.1999.12.Suppl_1.S-3","article-title":"Targeted delivery of inhaled drugs: Current challenges and future goals","volume":"12","author":"Ganderton","year":"1999","journal-title":"J Aerosol Med"},{"key":"10.1002\/jps.20694_bb0045","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1126\/science.276.5320.1868","article-title":"Large porous particles for pulmonary drug delivery","volume":"276","author":"Edwards","year":"1997","journal-title":"Science"},{"key":"10.1002\/jps.20694_bb0050","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1023\/A:1012058323754","article-title":"The AERX aerosol delivery system","volume":"14","author":"Schuster","year":"1997","journal-title":"Pharm Res"},{"key":"10.1002\/jps.20694_bb0055","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1513\/pats.200409-049TA","article-title":"The lungs as a portal of entry for systemic drug delivery","volume":"1","author":"Patton","year":"2004","journal-title":"Proc Am Thorac Soc"},{"key":"10.1002\/jps.20694_bb0060","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/S0009-9236(97)90079-5","article-title":"Morphine pharmacokinetics after pulmonary administration from a novel aerosol delivery system","volume":"62","author":"Ward","year":"1997","journal-title":"Clin Pharmacol Ther"},{"key":"10.1002\/jps.20694_bb0065","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1021\/cr60252a002","article-title":"The chemical composition of tobacco and tobacco smoke","volume":"68","author":"Stedman","year":"1968","journal-title":"Chem Rev"},{"key":"10.1002\/jps.20694_bb0070","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0091-3057(88)90280-8","article-title":"\u201cCrack smoke\u201d is a respirable aerosol of cocaine base","volume":"29","author":"Snyder","year":"1988","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1002\/jps.20694_bb0075","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/jat\/23.1.41","article-title":"Determination of pyrolysis products of smoked methamphetamine mixed with tobacco by tandem mass spectrometry","volume":"23","author":"Lee","year":"1999","journal-title":"J Anal Toxicol"},{"key":"10.1002\/jps.20694_bb0080","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/jat\/18.6.317","article-title":"Pharmacokinetics and pharmacodynamics of smoked heroin","volume":"18","author":"Jenkins","year":"1994","journal-title":"J Anal Toxicol"},{"key":"10.1002\/jps.20694_bb0085","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1093\/jat\/19.6.459","article-title":"Pharmacokinetics and pharmacodynamics of cocaine","volume":"19","author":"Cone","year":"1995","journal-title":"J Anal Toxicol"},{"key":"10.1002\/jps.20694_bb0090","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1124\/jpet.103.062893","article-title":"Fast onset medications through thermally generated aerosols","volume":"309","author":"Rabinowitz","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1002\/jps.20694_bb0095","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1080\/15298668091424951","article-title":"Distortion of cascade impactor measured size distribution due to bounce and blow-off","volume":"41","author":"Esmen","year":"1980","journal-title":"Am Ind Hyg Assoc J"},{"key":"10.1002\/jps.20694_bb0100","first-page":"29","article-title":"Particle transport onto human airway surfaces","volume":"119","author":"Heyder","year":"1982","journal-title":"Eur J Respir Dis Suppl"},{"key":"10.1002\/jps.20694_bb0105","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1089\/089426802320282257","article-title":"Drug absorption by the respiratory mucosa: Cell culture models and particulate drug carriers","volume":"15","author":"Ehrhardt","year":"2002","journal-title":"J Aerosol Med"},{"key":"10.1002\/jps.20694_bb0110","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1136\/thx.49.6.549","article-title":"Relative bioavailability of salbutamol to the lung following inhalation using metered dose inhalation methods and spacer devices","volume":"49","author":"Hindle","year":"1994","journal-title":"Thorax"},{"key":"10.1002\/jps.20694_bb0115","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1513\/pats.200409-046TA","article-title":"Deposition of inhaled particles in the human respiratory tract and consequences for regional targeting in respiratory drug delivery","volume":"1","author":"Heyder","year":"2004","journal-title":"Proc Am Thorac Soc"},{"key":"10.1002\/jps.20694_bb0120","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1001\/jama.1990.03440150053020","article-title":"Arterial-venous differences in plasma concentrations of nicotine after cigarette smoking","volume":"263","author":"Henningfield","year":"1990","journal-title":"Jama"},{"key":"10.1002\/jps.20694_bb0125","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0376-8716(93)90030-T","article-title":"Higher levels of nicotine in arterial than in venous blood after cigarette smoking","volume":"33","author":"Henningfield","year":"1993","journal-title":"Drug Alcohol Depend"},{"key":"10.1002\/jps.20694_bb0130","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1016\/0959-8049(92)90006-N","article-title":"A randomised double-blind study of high-dose intravenous prochlorperazine versus high-dose metoclopramide as antiemetics for cancer chemotherapy","volume":"28A","author":"Olver","year":"1992","journal-title":"Eur J Cancer"},{"key":"10.1002\/jps.20694_bb0135","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0196-0644(84)80473-4","article-title":"Intravenous prochlorperazine for the rapid control of vomiting in the emergency department","volume":"13","author":"Ordog","year":"1984","journal-title":"Ann Emerg Med"},{"key":"10.1002\/jps.20694_bb0140","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0735-6757(87)90095-7","article-title":"Intravenous prochlorperazine for the rapid control of nausea and vomiting in acute myocardial infarction: A clinical observation","volume":"5","author":"Wasserberger","year":"1987","journal-title":"Am J Emerg Med"},{"key":"10.1002\/jps.20694_bb0145","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/j.1553-2712.1998.tb02463.x","article-title":"Intravenous ketorolac vs intravenous prochlorperazine for the treatment of migraine headaches","volume":"5","author":"Seim","year":"1998","journal-title":"Acad Emerg Med"},{"key":"10.1002\/jps.20694_bb0150","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0196-0644(95)70001-3","article-title":"Randomized, placebo-controlled evaluation of prochlorperazine versus metoclopramide for emergency department treatment of migraine headache","volume":"26","author":"Coppola","year":"1995","journal-title":"Ann Emerg Med"},{"key":"10.1002\/jps.20694_bb0155","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0733-8619(18)30322-0","article-title":"Modern pharmacotherapy of migraine","volume":"8","author":"Raskin","year":"1990","journal-title":"Neurol Clin"},{"key":"10.1002\/jps.20694_bb0160","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1007\/BF00431449","article-title":"Pharmacokinetics and pharmacodynamics of alprazolam after oral and IV administration","volume":"84","author":"Smith","year":"1984","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1002\/jps.20694_bb0165","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/BF02244944","article-title":"Dose-dependent effects of intravenous alprazolam on neuroendocrine, biochemical, cardiovascular, and behavioral parameters in humans","volume":"111","author":"Osman","year":"1993","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1002\/jps.20694_bb0170","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1007\/BF00589900","article-title":"Intravenous alprazolam challenge in normal subjects. Biochemical, cardiovascular, and behavioral effects","volume":"99","author":"Risby","year":"1989","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1002\/jps.20694_bb0175","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1176\/ajp.151.8.1220","article-title":"Alprazolam blockade of CO2-provoked panic in patients with panic disorder","volume":"151","author":"Sanderson","year":"1994","journal-title":"Am J Psychiatry"},{"key":"10.1002\/jps.20694_bb0180","first-page":"19","article-title":"The use of low-dose intranasal midazolam to treat panic disorder: A pilot study","volume":"53","author":"Schweizer","year":"1992","journal-title":"J Clin Psychiatry"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354916321372?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354916321372?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,20]],"date-time":"2019-04-20T09:52:25Z","timestamp":1555753945000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354916321372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["S0022354916321372"],"URL":"https:\/\/doi.org\/10.1002\/jps.20694","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2006,11]]}}}