{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:26:53Z","timestamp":1758396413153},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1002\/jps.21094","type":"journal-article","created":{"date-parts":[[2007,8,9]],"date-time":"2007-08-09T20:46:31Z","timestamp":1186692391000},"page":"368-380","source":"Crossref","is-referenced-by-count":8,"title":["Silicone Elastomer Uptake Method for Determination of Free 1\u2010Alkyl\u20102\u2010Pyrrolidone Concentration in Micelle and Hydroxypropyl\u2010\u03b2\u2010Cyclodextrin Systems Used in Skin Transport Studies"],"prefix":"10.1016","volume":"97","author":[{"given":"Kevin S.","family":"Warner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalia S.","family":"Shaker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Molokhia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingfang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinsong","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William I.","family":"Higuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.Kevin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1002\/jps.21094_bb0010","article-title":"Pharmaceutical skin penetration enhancers","year":"1993"},{"key":"10.1002\/jps.21094_bb0015","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1002\/jps.2600841208","article-title":"Transdermal delivery of drugs with differing lipophilicities using azone analogs as dermal penetration enhancers","volume":"84","author":"Phillips","year":"1995","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.21094_bb0020","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/jps.2600800111","article-title":"Effect of 1\u2010alkyl\u2010 or 1\u2010alkenylazacycloalkanone derivatives on the penetration of drugs with different lipophilicities through guinea pig skin","volume":"80","author":"Okamoto","year":"1991","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.21094_bb0025","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1023\/A:1010952731205","article-title":"Effect of bilayer distruption on transdermal transport of low\u2010molecular weight hydrophobic solutes","volume":"18","author":"Mitragotri","year":"2001","journal-title":"Pharm Res"},{"key":"10.1002\/jps.21094_bb0030","doi-asserted-by":"crossref","first-page":"593","DOI":"10.2174\/0929867003374840","article-title":"Structure\u2010activity relationship of chemical penetration enhancers in transdermal drug delivery","volume":"7","author":"Kanikkannan","year":"2000","journal-title":"Curr Med Chem"},{"key":"10.1002\/jps.21094_bb0035","article-title":"Mechanisms of transdermal drug delivery","year":"1997"},{"key":"10.1002\/jps.21094_bb0040","article-title":"Percutaneous penetration enhancers","year":"1995"},{"key":"10.1002\/jps.21094_bb0045","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1002\/jps.20030","article-title":"Mechanistic study of chemical skin permeation enhancers with different polar and lipophilic functional groups","volume":"93","author":"He","year":"2004","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.21094_bb0050","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1002\/jps.10550","article-title":"Mechanistic studies of branched\u2010chain alkanols as skin permeation enhancers","volume":"93","author":"Chantasart","year":"2004","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.21094_bb0055","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1002\/jps.1068","article-title":"Influences of alkyl group chain length and polar head group on chemical skin permeation enhancement","volume":"90","author":"Warner","year":"2001","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.21094_bb0060","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1002\/jps.10367","article-title":"Structure\u2010activity relationship for chemical skin permeation enhancers: probing the chemical microenvironment of the site of action","volume":"92","author":"Warner","year":"2003","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.21094_bb0065","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/jps.10269","article-title":"Mechanistic study of alkyl azacycloheptanones as skin permeation enhancers by permeation and partition experiments with hairless mouse skin","volume":"92","author":"He","year":"2003","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.21094_bb0070","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/jps.2600840310","article-title":"Mechanistic studies of the 1\u2010alkyl\u20102\u2010pyrrolidones as skin permeation enhancers","volume":"84","author":"Yoneto","year":"1995","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.21094_bb0075","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1021\/js970190k","article-title":"Influence of the permeation enhancers 1\u2010alkyl\u20102\u2010pyrrolidones on permeant partitioning into the stratum corneum","volume":"87","author":"Yoneto","year":"1998","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.21094_bb0080","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1023\/A:1012136608249","article-title":"Cyclodextrins: Their future in drug formulation and delivery","volume":"14","author":"Stella","year":"1997","journal-title":"Pharm Res"},{"key":"10.1002\/jps.21094_bb0085","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1021\/js960075u","article-title":"Pharmaceutical applications of cyclodextrins. 2. In vivo drug delivery","volume":"85","author":"Rajewski","year":"1996","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.21094_bb0090","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1021\/js950534b","article-title":"Pharmaceutical applications of cyclodextrins. 1 Drug solubilization and stabilization","volume":"85","author":"Loftsson","year":"1996","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.21094_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5173(02)00625-7","article-title":"Mechanistic studies of the effect of hydroxypropyl\u2010beta\u2010cyclodextrin on in vitro transdermal permeation of corticosterone through hairless mouse skin","volume":"253","author":"Shaker","year":"2003","journal-title":"Int J Pharm"},{"key":"10.1002\/jps.21094_bb0100","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0168-3659(87)90065-4","article-title":"The effects of ethanol on the transport of estradiol and other permeants in hairless mouse skin II. A new quantitative approach","volume":"6","author":"Ghanem","year":"1987","journal-title":"J Cont Rel"},{"key":"10.1002\/jps.21094_bb0105","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0378-5173(92)90365-9","article-title":"The effects of ethanol on the transport of lipophilic and polar permeants across hairless mouse skin: Methods\/validation of a model approach","volume":"78","author":"Ghanem","year":"1992","journal-title":"Int J Pharm"},{"key":"10.1002\/jps.21094_bb0110","first-page":"145","article-title":"Model studies of epidermal permeability","volume":"11","author":"Kim","year":"1992","journal-title":"Semin Dermatol"},{"key":"10.1002\/jps.21094_bb0115","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0378-5173(92)90258-4","article-title":"Short chain alkanols as transport enhancers for lipophilic and polar\/ionic permeants in hairless mouse skin: Mechanism(s) of action","volume":"80","author":"Kim","year":"1995","journal-title":"Int J Pharm"},{"key":"10.1002\/jps.21094_bb0120","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1063\/1.555833","article-title":"Octanol\u2010water partition coefficients of simple organic compounds","volume":"18","author":"Sangster","year":"1989","journal-title":"J Phys Ref Data"},{"key":"10.1002\/jps.21094_bb0125","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1063\/1.1347983","article-title":"Physicochemical properties of higher nonaromatic hydrocarbons: A literature study","volume":"29","author":"Verbruggen","year":"2001","journal-title":"J Phys Chem Ref Data"},{"key":"10.1002\/jps.21094_bb0130","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1023\/A:1015921702258","article-title":"Structure\/effect studies of fatty acid isomers as skin penetration enhancers and skin irritants","volume":"6","author":"Aungst","year":"1989","journal-title":"Pharm Res"},{"key":"10.1002\/jps.21094_bb0135","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/jps.2600760108","article-title":"Role of stratum corneum lipid fluidity in transdermal drug flux","volume":"76","author":"Golden","year":"1987","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.21094_bb0140","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1023\/A:1012099216060","article-title":"In vitro human skin barrier modulation by fatty acids: Skin permeation and thermal analysis studies","volume":"14","author":"Tanojo","year":"1997","journal-title":"Pharm Res"},{"key":"10.1002\/jps.21094_bb0145","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1021\/cr60274a001","article-title":"Partition coefficients and their uses","volume":"71","author":"Leo","year":"1971","journal-title":"Chem Rev"},{"key":"10.1002\/jps.21094_bb0150","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/1523-1747.ep12277592","article-title":"Solute structure\u2010permeability relationships in human stratum corneum","volume":"93","author":"Anderson","year":"1989","journal-title":"J Invest Dermatol"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354916324686?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354916324686?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T21:58:30Z","timestamp":1556747910000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354916324686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S0022354916324686"],"URL":"https:\/\/doi.org\/10.1002\/jps.21094","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}