{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:35:06Z","timestamp":1787769306547,"version":"build-2784847793"},"reference-count":31,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1002\/jps.21670","type":"journal-article","created":{"date-parts":[[2009,1,7]],"date-time":"2009-01-07T21:01:34Z","timestamp":1231362094000},"page":"3647-3658","source":"Crossref","is-referenced-by-count":12,"title":["Novel Methodology for Predicting Photogenotoxic Risk of Pharmaceutical Substances Based on Reactive Oxygen Species (ROS) and DNA-Binding Assay"],"prefix":"10.1016","volume":"98","author":[{"given":"Satomi","family":"Onoue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Seto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ami","family":"Oishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizuo","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1002\/jps.21670_bb0010","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0190-9622(83)70016-2","article-title":"Phototoxicity and photoallergy in man","volume":"8","author":"Epstein","year":"1983","journal-title":"J Am Acad Dermatol"},{"key":"10.1002\/jps.21670_bb0015","doi-asserted-by":"crossref","first-page":"42","DOI":"10.2165\/00003495-198530010-00005","article-title":"Photosensitivity due to drugs","volume":"30","author":"Epstein","year":"1985","journal-title":"Drugs"},{"key":"10.1002\/jps.21670_bb0020","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s11095-005-8497-9","article-title":"Analytical studies on the prediction of photosensitive\/phototoxic potential of pharmaceutical substances","volume":"23","author":"Onoue","year":"2006","journal-title":"Pharm Res"},{"key":"10.1002\/jps.21670_bb0025","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0378-4274(98)00235-5","article-title":"The photomutagenicity of fluoroquinolones and other drugs","volume":"102\u2013103","author":"Gocke","year":"1998","journal-title":"Toxicol Lett"},{"key":"10.1002\/jps.21670_bb0030","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.jpba.2008.03.026","article-title":"Reactive oxygen species assay-based risk assessment of drug-induced phototoxicity: Classification criteria and application to drug candidates","volume":"47","author":"Onoue","year":"2008","journal-title":"J Pharm Biomed Anal"},{"key":"10.1002\/jps.21670_bb0035","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.chroma.2007.09.084","article-title":"Capillary electrophoretic studies on the photogenotoxic potential of pharmaceutical substances","volume":"1188","author":"Onoue","year":"2008","journal-title":"J Chromatogr A"},{"key":"10.1002\/jps.21670_bb0040","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jpba.2007.09.003","article-title":"High-throughput reactive oxygen species (ROS) assay: An enabling technology for screening the phototoxic potential of pharmaceutical substances","volume":"46","author":"Onoue","year":"2008","journal-title":"J Pharm Biomed Anal"},{"key":"10.1002\/jps.21670_bb0045","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s11095-007-9383-4","article-title":"Analytical studies on photochemical behavior of phototoxic substances; effect of detergent additives on singlet oxygen generation","volume":"25","author":"Onoue","year":"2008","journal-title":"Pharm Res"},{"key":"10.1002\/jps.21670_bb0050","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0014-827X(99)00116-0","article-title":"In vitro studies of the phototoxic potential of the antidepressant drugs amitriptyline and imipramine","volume":"55","author":"Viola","year":"2000","journal-title":"Il Farmaco"},{"key":"10.1002\/jps.21670_bb0055","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/j.1751-1097.1991.tb02071.x","article-title":"Definition of type I and type II photosensitized oxidation","volume":"54","author":"Foote","year":"1991","journal-title":"Photochem Photobiol"},{"key":"10.1002\/jps.21670_bb0060","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1751-1097.1978.tb06972.x","article-title":"A new method for the detection of singlet oxygen in aqueous solutions","volume":"28","author":"Kraljic","year":"1978","journal-title":"Photochem Photobiol"},{"key":"10.1002\/jps.21670_bb0065","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1161\/hh1501.094365","article-title":"Methods of detection of vascular reactive species: Nitric oxide, superoxide, hydrogen peroxide, and peroxynitrite","volume":"89","author":"Tarpey","year":"2001","journal-title":"Circ Res"},{"key":"10.1002\/jps.21670_bb0070","first-page":"1407","article-title":"Azapsoralens: New potential photochemotherapeutic agents for psoriasis","volume":"46","author":"Vedaldi","year":"1991","journal-title":"Farmaco"},{"key":"10.1002\/jps.21670_bb0075","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1021\/tx0501740","article-title":"The mechanism of guanine specific photooxidation in the presence of berberine and palmatine: Activation of photosensitized singlet oxygen generation through DNA-binding interaction","volume":"18","author":"Hirakawa","year":"2005","journal-title":"Chem Res Toxicol"},{"key":"10.1002\/jps.21670_bb0080","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1007\/BF01951722","article-title":"Alternariol, a dibenzopyrone mycotoxin of Alternaria spp., is a new photosensitizing and DNA cross-linking agent","volume":"41","author":"DiCosmo","year":"1985","journal-title":"Experientia"},{"key":"10.1002\/jps.21670_bb0085","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0022-2836(65)80096-1","article-title":"Complex formation between ethidium bromide and nucleic acids","volume":"13","author":"Waring","year":"1965","journal-title":"J Mol Biol"},{"key":"10.1002\/jps.21670_bb0090","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jinorgbio.2005.09.008","article-title":"Synthesis, characterization and DNA-binding properties of rac-[Ru(5,6-dmp)2(dppz)]2+\u2013enantiopreferential DNA binding and co-ligand promoted exciton coupling","volume":"100","author":"Maheswari","year":"2006","journal-title":"J Inorg Biochem"},{"key":"10.1002\/jps.21670_bb0095","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0301-4622(02)00006-6","article-title":"Conformational transition of DNA induced by cationic lipid vesicle in acidic solution: Spectroscopy investigation","volume":"97","author":"Zhang","year":"2002","journal-title":"Biophys Chem"},{"key":"10.1002\/jps.21670_bb0100","first-page":"1031","article-title":"Evaluation of phototoxic properties of oral antidiabetics and diuretics. Photohemolysis model as a screening method for recognizing potential photosensitizing drugs","volume":"47","author":"Selvaag","year":"1997","journal-title":"Arzneimittelforschung"},{"key":"10.1002\/jps.21670_bb0105","first-page":"101","article-title":"Screening for drug photosensitization activity by measuring the variations in oxygen consumption of Bacillus subtilis","volume":"2","author":"Beani","year":"1985","journal-title":"Photodermatology"},{"key":"10.1002\/jps.21670_bb0110","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1034\/j.1600-0781.2002.180207.x","article-title":"Use of human reconstituted epidermis Episkin for assessment of weak phototoxic potential of chemical compounds","volume":"18","author":"Portes","year":"2002","journal-title":"Photodermatol Photoimmunol Photomed"},{"key":"10.1002\/jps.21670_bb0115","first-page":"22","article-title":"First results of an EC\/COLIPA validation project of in vitro phototoxicity testing methods","volume":"11","author":"Spielmann","year":"1994","journal-title":"Altex"},{"key":"10.1002\/jps.21670_bb0120","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1177\/026119290002800603","article-title":"The second ECVAM workshop on phototoxicity testing. The report and recommendations of ECVAM workshop 42","volume":"28","author":"Spielmann","year":"2000","journal-title":"Altern Lab Anim"},{"key":"10.1002\/jps.21670_bb0125","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S1383-5742(03)00052-8","article-title":"Photochemical genotoxicity: Principles and test methods. Report of a GUM task force","volume":"566","author":"Brendler-Schwaab","year":"2004","journal-title":"Mutat Res"},{"key":"10.1002\/jps.21670_bb0130","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0378-4274(01)00492-1","article-title":"Currently available in vitro methods used in the regulatory toxicology","volume":"127","author":"Liebsch","year":"2002","journal-title":"Toxicol Lett"},{"key":"10.1002\/jps.21670_bb0135","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1093\/carcin\/18.12.2379","article-title":"Induction of oxidative DNA base damage in human skin cells by UV and near visible radiation","volume":"18","author":"Kvam","year":"1997","journal-title":"Carcinogenesis"},{"key":"10.1002\/jps.21670_bb0140","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1111\/j.1751-1097.1993.tb09209.x","article-title":"UV irradiation of nucleic acids: Characterization of photoproducts of thymidylyl-(3\u2032\u21925\u2032)-2\u2032-deoxy-5-fluorouridine","volume":"57","author":"Alderfer","year":"1993","journal-title":"Photochem Photobiol"},{"key":"10.1002\/jps.21670_bb0145","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0378-4347(00)00106-7","article-title":"Analysis of gamma radiation-induced damage to plasmid DNA using dynamic size-sieving capillary electrophoresis","volume":"741","author":"Nevins","year":"2000","journal-title":"J Chromatogr B"},{"key":"10.1002\/jps.21670_bb0150","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.1021\/bi00638a014","article-title":"Electrophoresis of DNA in agarose gels. Optimizing separations of conformational isomers of double- and single-stranded DNAs","volume":"16","author":"Johnson","year":"1977","journal-title":"Biochemistry"},{"key":"10.1002\/jps.21670_bb0155","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/0003-2697(92)90176-8","article-title":"Quantitation of supercoiled DNA cleavage in nonradioactive DNA: Application to ionizing radiation and synthetic endonuclease cleavage","volume":"201","author":"Sutherland","year":"1992","journal-title":"Anal Biochem"},{"key":"10.1002\/jps.21670_bb0160","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0378-4347(95)00584-6","article-title":"Analysis of laser-induced plasmic DNA photolysis by capillary electrophoresis","volume":"683","author":"Nackerdien","year":"1996","journal-title":"J Chromatogr B Biomed Appl"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002235491633115X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002235491633115X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T13:23:21Z","timestamp":1655385801000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002235491633115X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":31,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["S002235491633115X"],"URL":"https:\/\/doi.org\/10.1002\/jps.21670","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]}}}