{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T02:47:30Z","timestamp":1784774850535,"version":"3.55.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1002\/jps.21734","type":"journal-article","created":{"date-parts":[[2009,7,30]],"date-time":"2009-07-30T14:51:31Z","timestamp":1248965491000},"page":"4216-4228","source":"Crossref","is-referenced-by-count":26,"title":["Differences in the interaction between aryl propionic acid derivatives and poly(vinylpyrrolidone) K30: A multi-methodological approach"],"prefix":"10.1016","volume":"98","author":[{"given":"Zehadin","family":"Gashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Censi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ledjan","family":"Malaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Gobetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Mozzicafreddo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Angeletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Admir","family":"Masic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piera","family":"Di Martino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1002\/jps.21734_bb0010","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0378-5173(01)00891-2","article-title":"The mechanism of drug release from solid dispersions in water-soluble polymers","volume":"231","author":"Craig","year":"2000","journal-title":"Int J Pharm"},{"key":"10.1002\/jps.21734_bb0015","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0939-6411(00)00076-X","article-title":"Improving drug solubility for oral delivery using solid dispersions","volume":"50","author":"Leuner","year":"2000","journal-title":"Eur J Pharm Biopharm"},{"key":"10.1002\/jps.21734_bb0020","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ejpb.2006.04.001","article-title":"Preparation of solid dispersion of felodipine using a solvent wetting method","volume":"64","author":"Kim","year":"2006","journal-title":"Eur J Pharm Biopharm"},{"key":"10.1002\/jps.21734_bb0025","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ijpharm.2006.12.028","article-title":"Development and optimization of solid dispersion containing pellets of itraconazole by high shear pellettization","volume":"337","author":"Ye","year":"2007","journal-title":"Int J Pharm"},{"key":"10.1002\/jps.21734_bb0030","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.ejpb.2006.11.020","article-title":"Investigation of the release mechanism of a sparingly water-soluble drug from solid dispersions in hydrophilic carriers based on physical state of drug, particle size distribution and drug-polymer interaction","volume":"66","author":"Karavas","year":"2007","journal-title":"Eur J Pharm Biopharm"},{"key":"10.1002\/jps.21734_bb0035","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ijpharm.2006.08.010","article-title":"Use of surfactants as plasticizers in preparing solid dispersions of poorly soluble API: Selection of polymer-surfactant combinations using solubility parameters and testing the processability","volume":"328","author":"Ghebremeskel","year":"2007","journal-title":"Int J Pharm"},{"key":"10.1002\/jps.21734_bb0040","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ijpharm.2004.12.019","article-title":"Solid dispersion particles of amorphous indomethacin with fine porous silica particles by using spray-drying method","volume":"293","author":"Takeuchi","year":"2005","journal-title":"Int J Pharm"},{"key":"10.1002\/jps.21734_bb0045","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0378-5173(00)00485-3","article-title":"The formulation of halofantrine as either non-solubilizing PEG 6000 or solubilizing lipid based solid dispersions: Physical stability and absolute bioavailability assessment","volume":"205","author":"Khoo","year":"2000","journal-title":"Int J Pharm"},{"key":"10.1002\/jps.21734_bb0050","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s10973-005-0859-3","article-title":"Characterization of solid dispersions of rofecoxib using differential scanning calorimeter","volume":"82","author":"Mashru","year":"2005","journal-title":"J Therm Anal Calorim"},{"key":"10.1002\/jps.21734_bb0055","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0378-5173(02)00019-4","article-title":"Solid-state characterization of nifedipine solid dispersions","volume":"236","author":"Vippagunta","year":"2002","journal-title":"Int J Pharm"},{"key":"10.1002\/jps.21734_bb0060","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1248\/cpb.43.988","article-title":"Solid-state interaction of ibuprofen with polyvinylpyrrolidone","volume":"43","author":"Sekizaki","year":"1995","journal-title":"Chem Pham Bull"},{"key":"10.1002\/jps.21734_bb0065","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1007\/s11095-005-2598-3","article-title":"Interactions of poly(vinylpyrrolidone) with ibuprofen and naproxen: Experimental and modeling studies","volume":"5","author":"Bogdanova","year":"2005","journal-title":"Pharm Res"},{"key":"10.1002\/jps.21734_bb0070","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.jcrysgro.2004.02.023","article-title":"Ketoprofen-poly(vinylpyrrolidone) physical interaction","volume":"265","author":"Di Martino","year":"2004","journal-title":"J Cryst Growth"},{"key":"10.1002\/jps.21734_bb0075","doi-asserted-by":"crossref","unstructured":"Dauber-Osguthorpe P,Roberts VA,Osguthorpe DJ,Wolff J,Genest M,Hagler AT.1988.Structure and energetics of ligand binding to proteins: E. Coli dihydrofolate reductase-trimethoprim, a drug-receptor system. Proteins: Structure, function and genetics.4:31\u201347.","DOI":"10.1002\/prot.340040106"},{"key":"10.1002\/jps.21734_bb0080","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1023\/A:1007999920146","article-title":"Prediction of binding constants of protein ligands: A fast method for the prioritization of hits obtained from de novo design or 3D database search programs","volume":"12","author":"Bohm","year":"1998","journal-title":"J Comput Aided Mol Des"},{"key":"10.1002\/jps.21734_bb0085","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1007\/s11095-005-6249-5","article-title":"Molecular properties of ibuprofen and its solid dispersions with Eudragit RL100 studied by solid-state nuclear magnetic resonance","volume":"22","author":"Geppi","year":"2005","journal-title":"Pharm Res"},{"key":"10.1002\/jps.21734_bb0090","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1007\/s11095-006-9044-z","article-title":"Molecular properties of flurbiprofen and its solid dispersions with Eudragit RL100 studied by high- and low-resolution solid-state nuclear magnetic resonance","volume":"23","author":"Mollica","year":"2006","journal-title":"Pharm Res"},{"key":"10.1002\/jps.21734_bb0095","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1039\/b500674k","article-title":"A combined first principles computational and solid state NMR study of a molecular crystal: Flurbiprofen","volume":"7","author":"Yates","year":"2005","journal-title":"Phys Chem Chem Phys"},{"key":"10.1002\/jps.21734_bb0100","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/jps.20741","article-title":"A new tetrahydrated form of sodium naproxen","volume":"96","author":"Di Martino","year":"2007","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.21734_bb0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/js9601896","article-title":"Characteristics and significance of the amorphous state in pharmaceutical systems","volume":"86","author":"Hancock","year":"1997","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.21734_bb0110","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1023\/A:1016292416526","article-title":"Molecular mobility of amorphous pharmaceutical solids below their glass transition temperature","volume":"12","author":"Hancock","year":"1995","journal-title":"Pharm Res"},{"key":"10.1002\/jps.21734_bb0115","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0928-0987(00)00173-1","article-title":"Physical stabilisation of amorphous ketoconazole in solid dispersions with polyvinylpyrrolidone K25","volume":"12","author":"Van den Mooter","year":"2001","journal-title":"Eur J Pharm Sci"},{"key":"10.1002\/jps.21734_bb0120","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ijpharm.2005.12.007","article-title":"Characterization of the molecular distribution of the drugs in glassy solid dispersions at the nano-meter scale, using differential scanning calorimetry, gravimetric water vapour sorption techniques","volume":"310","author":"van Drooge","year":"2006","journal-title":"Int J Pharm"},{"key":"10.1002\/jps.21734_bb0125","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/jctb.5010020901","article-title":"Ideal copolymers and the second-order transitions of synthetic rubbers. I. Noncrystalline copolymers","volume":"2","author":"Gordon","year":"1952","journal-title":"J Appl Chem"},{"key":"10.1002\/jps.21734_bb0130","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1063\/1.1733201","article-title":"General relation involving the glass temperature and coefficient of expansion of polymers","volume":"37","author":"Simha","year":"1962","journal-title":"J Chem Phys"},{"key":"10.1002\/jps.21734_bb0135","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1023\/A:1015834715152","article-title":"The relationship between the glass transition temperature and water vapour absorption by poly(vinylpyrrolidone)","volume":"7","author":"Oksanen","year":"1990","journal-title":"Pharm Res"},{"key":"10.1002\/jps.21734_bb0140","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0378-5173(01)00767-0","article-title":"Influence of various drugs on the glass transition temperature of poly(vinylpyrrolidone): A thermodynamic and spectroscopic investigation","volume":"225","author":"Nair","year":"2001","journal-title":"Int J Pharm"},{"key":"10.1002\/jps.21734_bb0145","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/0032-3861(89)90172-9","article-title":"Glass transition behaviour of compatible polymer blends","volume":"30","author":"Schneider","year":"1989","journal-title":"Polymer"},{"key":"10.1002\/jps.21734_bb0150","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1126\/science.267.5206.1924","article-title":"Formation of glasses from liquids and biopolymers","volume":"267","author":"Angell","year":"1995","journal-title":"Science"},{"key":"10.1002\/jps.21734_bb0155","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1002\/1520-6017(200010)89:10<1325::AID-JPS10>3.0.CO;2-5","article-title":"Crystallization inhibition in solid dispersions of MK-0591 and poly(vinylpyrrolidone) polymers","volume":"89","author":"Khougaz","year":"2000","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.21734_bb0160","series-title":"The weak hydrogen bond","author":"Desiraju","year":"1999"},{"key":"10.1002\/jps.21734_bb0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0040-6031(71)85051-7","article-title":"Kinetics of the mechanism of solid-state reactions at increasing temperature","volume":"3","author":"\u0160est\u00e1k","year":"1971","journal-title":"Thermochim Acta"},{"key":"10.1002\/jps.21734_bb0170","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1002\/jps.10153","article-title":"Dehydration kinetics of neotame monohydrate","volume":"91","author":"Dong","year":"2002","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.21734_bb0175","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1002\/jps.10159","article-title":"Characterization of ibuprofen as a non-traditional plasticizer of ethyl cellulose","volume":"91","author":"De Brabander","year":"2002","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.21734_bb0180","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jconrel.2006.08.016","article-title":"Drugs acting as plasticizer in polymeric systems: A quantitative treatment","volume":"115","author":"Siepmann","year":"2006","journal-title":"J Control Release"},{"key":"10.1002\/jps.21734_bb0185","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0378-5173(98)00312-3","article-title":"Non-traditional plasticization of polymeric films","volume":"177","author":"Wu","year":"1999","journal-title":"Int J Pharm"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002235491532952X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002235491532952X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T19:54:31Z","timestamp":1558468471000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002235491532952X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S002235491532952X"],"URL":"https:\/\/doi.org\/10.1002\/jps.21734","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2009,11]]}}}