{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:02:59Z","timestamp":1789192979434,"version":"build-2803163510"},"reference-count":62,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1002\/jps.22589","type":"journal-article","created":{"date-parts":[[2011,5,31]],"date-time":"2011-05-31T22:33:30Z","timestamp":1306881210000},"page":"4368-4382","source":"Crossref","is-referenced-by-count":59,"title":["Solubility Prediction of Drugs in Mixed Solvents Using Partial Solubility Parameters"],"prefix":"10.1016","volume":"100","author":[{"given":"Abolghasem","family":"Jouyban","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Shayanfar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahid","family":"Panahi-Azar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jafar","family":"Soleymani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BehroozH.","family":"Yousefi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"WilliamE.","family":"Acree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"York","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1002\/jps.22589_bb0010","series-title":"Handbook of solubility data for pharmaceuticals","author":"Jouyban","year":"2009"},{"key":"10.1002\/jps.22589_bb0015","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1023\/B:PHAM.0000016235.32639.23","article-title":"Solubilizing excipients in oral and injectable formulations","volume":"21","author":"Strickley","year":"2004","journal-title":"Pharm Res"},{"key":"10.1002\/jps.22589_bb0020","doi-asserted-by":"crossref","unstructured":"Miyako Y, Khalef N, Matsuzaki K, Pinal R.Solubility enhancement of hydrophobic compounds by cosolvents: Role of solute hydrophobicity on the solubilization effect Int J Pharm 393 48-54","DOI":"10.1016\/j.ijpharm.2010.03.059"},{"key":"10.1002\/jps.22589_bb0025","series-title":"Encyclopedia of pharmaceutical technology","first-page":"375","article-title":"Cosolvent and cosolvency","author":"Rubino","year":"1990"},{"key":"10.1002\/jps.22589_bb0030","doi-asserted-by":"crossref","first-page":"4854","DOI":"10.1021\/ie0200353","article-title":"Solubility measurement using differential scanning calorimetry","volume":"41","author":"Mohan","year":"2002","journal-title":"Ind Eng Chem Res"},{"key":"10.1002\/jps.22589_bb0035","first-page":"19","article-title":"Improved prediction of drug solubilities in ethanol + water mixtures at various temperatures","volume":"1","author":"Jouyban","year":"2010","journal-title":"Biomed Int"},{"key":"10.1002\/jps.22589_bb0040","first-page":"117","article-title":"Phase-solubility techniques","volume":"4","author":"Higuchi","year":"1965","journal-title":"Adv Anal Chem Instrum"},{"key":"10.1002\/jps.22589_bb0045","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1248\/cpb.50.21","article-title":"Solubility prediction of anthracene in mixed solvents using a minimum number of experimental data","volume":"50","author":"Jouyban","year":"2002","journal-title":"Chem Pharm Bull"},{"key":"10.1002\/jps.22589_bb0050","series-title":"Water-insoluble drug formulation","author":"Liu","year":"2008"},{"key":"10.1002\/jps.22589_bb0055","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1600-0722.2007.00430.x","article-title":"Use of Hoy's solubility parameters to predict water sorption\/solubility of experimental primers and adhesives","volume":"115","author":"Nishitani","year":"2007","journal-title":"Eur J Oral Sci"},{"key":"10.1002\/jps.22589_bb0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5173(96)04828-4","article-title":"The use of solubility parameters in pharmaceutical dosage form design","volume":"148","author":"Hancock","year":"1997","journal-title":"Int J Pharm"},{"key":"10.1002\/jps.22589_bb0065","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1002\/jps.20370","article-title":"Relationship between swelling of hydroxypropylmethylcellulose and the Hansen and Karger partial solubility parameters","volume":"94","author":"Navarro-Lupio\u00f3n","year":"2005","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.22589_bb0070","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1023\/A:1011941319327","article-title":"Prediction of intestinal drug absorption properties by three-dimensional solubility parameters","volume":"15","author":"Breitkreutz","year":"1998","journal-title":"Pharm Res"},{"key":"10.1002\/jps.22589_bb0075","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0378-5173(80)90034-4","article-title":"Solubility parameters from maxima in solubility\/solvent plots","volume":"5","author":"Cave","year":"1980","journal-title":"Int J Pharm"},{"key":"10.1002\/jps.22589_bb0080","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1248\/cpb.42.1129","article-title":"Chameleonic effect of sulfanilamide and sulfamethazine in solvent mixtures. Solubility curves with two maxima","volume":"42","author":"Bustamante","year":"1994","journal-title":"Chem Pharm Bull"},{"key":"10.1002\/jps.22589_bb0085","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0040-6031(92)85059-5","article-title":"Mathematical representation of thermodynamic properties. Part 2. Derivation of the combined nearly ideal binary solvent (NIBS)\/Redlich-Kister mathematical representation from a two-body and three-body interactional mixing model","volume":"198","author":"Acree","year":"1992","journal-title":"Thermochim Acta"},{"key":"10.1002\/jps.22589_bb0090","series-title":"The Hoy solubility parameter calculation software","year":"2005"},{"key":"10.1002\/jps.22589_bb0095","series-title":"Hansen solubility parameters: A user's handbook","author":"Hansen","year":"2000"},{"key":"10.1002\/jps.22589_bb0100","first-page":"87","article-title":"Thermodynamic magnitudes of mixing and solvation of acetaminophen in ethanol+water cosolvent mixtures","volume":"30","author":"Jimenez","year":"2006","journal-title":"Rev Acad Colomb Cienc"},{"key":"10.1002\/jps.22589_bb0105","first-page":"505","article-title":"Thermodynamics of paracetamol in amphiprotic and amphiprotic-aprotic solvent mixtures","volume":"1","author":"Bustamante","year":"1995","journal-title":"Pharm Sci"},{"key":"10.1002\/jps.22589_bb0110","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1248\/cpb.44.1061","article-title":"The behavior of paracetamol in mixtures of amphiprotic and amphiprotic-aprotic solvents. Relationship of solubility curves to specific and nonspecific interactions","volume":"44","author":"Romero","year":"1996","journal-title":"Chem Pharm Bull"},{"key":"10.1002\/jps.22589_bb0115","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1248\/cpb.32.340","article-title":"Solubility of acetaminophen in cosolvents","volume":"32","author":"Prakongpan","year":"1984","journal-title":"Chem Pharm Bull"},{"key":"10.1002\/jps.22589_bb0120","doi-asserted-by":"crossref","unstructured":"Soltanpour S, Jouyban A. Solubility of acetaminophen and ibuprofen in polyethylene glycol 600, N-methyl pyrrolidone and water mixtures. J Solution Chem Accepted for publication.","DOI":"10.1007\/s10953-011-9767-2"},{"key":"10.1002\/jps.22589_bb0125","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.molliq.2006.05.005","article-title":"Physicochemical studies of acetaminophen in Water-PEG 400 systems","volume":"133","author":"Yurquina","year":"2007","journal-title":"J Mol Liq"},{"key":"10.1002\/jps.22589_bb0130","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1590\/S0103-50532006000100018","article-title":"Thermodynamic study of the solubility of acetaminophen in propylen glycol+water cosolvent mixtures","volume":"17","author":"Jimenez","year":"2006","journal-title":"J Braz Chem Soc"},{"key":"10.1002\/jps.22589_bb0135","series-title":"Solubilities of inorganic and organic compounds","author":"Stephen","year":"1964"},{"key":"10.1002\/jps.22589_bb0140","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ijpharm.2006.05.014","article-title":"Solubility parameter of drugs for predicting the solubility profile type within a wide polarity range in solvent mixtures","volume":"321","author":"Pe\u00f1a","year":"2006","journal-title":"Int J Pharm"},{"key":"10.1002\/jps.22589_bb0145","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/jps.2600590920","article-title":"Solubility profiles for several barbiturates in hydroalcoholic mixtures","volume":"59","author":"Breon","year":"1970","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.22589_bb0150","first-page":"276","article-title":"Solubility and the thermodynamics of transfer of benzoic acid in mixed solvents","volume":"28","author":"Pal","year":"1989","journal-title":"Ind J Chem A"},{"key":"10.1002\/jps.22589_bb0155","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0378-5173(97)00202-0","article-title":"Solubility prediction of caffeine in aqueous N,N-dimethylformamide mixtures using the extended Hildebrand solubility approach","volume":"156","author":"Herrador","year":"1997","journal-title":"Int J Pharm"},{"key":"10.1002\/jps.22589_bb0160","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1002\/jps.10076","article-title":"Thermodynamic origin of the solubility profile of drugs showing one or two maxima against the polarity of aqueous and nonaquoeus mixtures: Niflumic acid and caffeine","volume":"91","author":"Bustamante","year":"2002","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.22589_bb0165","doi-asserted-by":"crossref","first-page":"E33","DOI":"10.1208\/pt040333","article-title":"Solubility enhancement of COX-2 inhibitors using various solvent systems","volume":"4","author":"Seedher","year":"2003","journal-title":"AAPS Pharm Sci Tech"},{"key":"10.1002\/jps.22589_bb0170","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1021\/je900200k","article-title":"Solubility of chlordiazepoxide, diazepam, and lorazepam in ethanol+water mixtures at 303.2K","volume":"54","author":"Jouyban","year":"2009","journal-title":"J Chem Eng Data"},{"key":"10.1002\/jps.22589_bb0175","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1021\/je900330p","article-title":"Solubility of benzodiazepines in polyethylene glycol 200 + water mixtures at 303.2K","volume":"55","author":"Jouyban","year":"2010","journal-title":"J Chem Eng Data"},{"key":"10.1002\/jps.22589_bb0180","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1021\/je900451d","volume":"55","author":"Jouyban","year":"2010","journal-title":"J Chem Eng Data"},{"key":"10.1002\/jps.22589_bb0185","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1021\/je8007827","article-title":"Solubility of lamotrigine, diazepam, and clonazepam in ethanol + water mixtures at 298.15K","volume":"54","author":"Shayanfar","year":"2009","journal-title":"J Chem Eng Data"},{"key":"10.1002\/jps.22589_bb0190","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1021\/je800931z","article-title":"Solubility of lamotrigine, diazepam, clonazepam, and phenobarbital in propylene glycol + water mixtures at 298.15K","volume":"54","author":"Shayanfar","year":"2009","journal-title":"J Chem Eng Data"},{"key":"10.1002\/jps.22589_bb0195","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1021\/je9000153","article-title":"Solubility of clonazepam, diazepam, lamotrigine, and phenobarbital in N-methyl-2-pyrrolidone + water mixtures at 298.2K","volume":"54","author":"Shayanfar","year":"2009","journal-title":"J Chem Eng Data"},{"key":"10.1002\/jps.22589_bb0200","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1021\/je9005807","volume":"55","author":"Soltanpour","year":"2010","journal-title":"J Chem Eng Data"},{"key":"10.1002\/jps.22589_bb0205","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.molliq.2010.05.011","article-title":"Solubility of acetaminophen and ibuprofen in polyethylene glycol 600, propylene glycol and water mixtures at 25\u00b0C","volume":"155","author":"Soltanpour","year":"2010","journal-title":"J Mol Liq"},{"key":"10.1002\/jps.22589_bb0210","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1248\/cpb.58.219","article-title":"Solubility of acetaminophen and ibuprofen in binary and ternary mixtures of polyethylene glycol 600, ethanol and water","volume":"58","author":"Soltanpour","year":"2010","journal-title":"Chem Pharm Bull"},{"key":"10.1002\/jps.22589_bb0215","first-page":"737","article-title":"Cosolvent solubilization and formulation of an aqueous injection of ketoprofen","volume":"51","author":"Singhai","year":"1996","journal-title":"Pharmazie"},{"key":"10.1002\/jps.22589_bb0220","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1248\/cpb.50.594","article-title":"A cosolvency model to predict solubility of drugs at several temperatures from a limited number of solubility measurements","volume":"50","author":"Jouyban","year":"2002","journal-title":"Chem Pharm Bull"},{"key":"10.1002\/jps.22589_bb0225","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1080\/00319100701313862","article-title":"Thermodynamic analysis of the solubility of naproxen in ethanol + water cosolvent mixtures","volume":"45","author":"Pacheco","year":"2007","journal-title":"Phys Chem Liq"},{"key":"10.1002\/jps.22589_bb0230","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1248\/cpb.48.175","article-title":"Multiple solubility maxima of oxolinic acid in mixed solvents and a new extension of Hildebrand solubility approach","volume":"48","author":"Jouyban-Gharamaleki","year":"2000","journal-title":"Chem Pharm Bull"},{"key":"10.1002\/jps.22589_bb0235","first-page":"215","article-title":"Solubilization by cosolvents II: Phenytoin in binary and ternary solvents","volume":"38","author":"Rubino","year":"1984","journal-title":"J Parenter Sci Technol"},{"key":"10.1002\/jps.22589_bb0240","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1021\/je020213z","article-title":"Solubility of rofecoxib in the presence of methanol, ethanol, and sodium lauryl sulfate at (298.15, 303.15, and 308.15) K","volume":"48","author":"Desai","year":"2003","journal-title":"J Chem Eng Data"},{"key":"10.1002\/jps.22589_bb0245","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1021\/je050276s","article-title":"Solubility of rofecoxib in the presence of aqueous solutions of glycerol, propylene glycol, ethanol, Span 20, Tween 80, and sodium lauryl sulfate at (298.15, 303.15, and 308.15) K","volume":"50","author":"Liu","year":"2005","journal-title":"J Chem Eng Data"},{"key":"10.1002\/jps.22589_bb0250","first-page":"318","article-title":"Solubility prediction of salicylic acid in water-ethanol-propylene glycol mixtures using the Jouyban\u2013Acree model","volume":"61","author":"Jouyban","year":"2006","journal-title":"Pharmazie"},{"key":"10.1002\/jps.22589_bb0255","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/j.2042-7158.1968.tb09656.x","article-title":"The solubility of sulphadiazine in water-dimethylformamide mixtures","volume":"20","author":"Elworthy","year":"1968","journal-title":"J Pharm Pharmacol"},{"key":"10.1002\/jps.22589_bb0260","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.2042-7158.1993.tb05548.x","article-title":"A modification of the extended Hildebrand approach to predict the solubility of structurally related drugs in solvent mixtures","volume":"45","author":"Bustamante","year":"1993","journal-title":"J Pharm Pharmacol"},{"key":"10.1002\/jps.22589_bb0265","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0378-5173(89)90192-0","article-title":"The effect of hydrate formation on the solubility of theophylline in binary aqueous cosolvent systems","volume":"51","author":"Gould","year":"1989","journal-title":"Int J Pharm"},{"key":"10.1002\/jps.22589_bb0270","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1021\/je0496948","article-title":"Solubility of valdecoxib in the presence of ethanol and sodium lauryl sulfate at (298.15, 303.15, and 308.15) K","volume":"49","author":"Liu","year":"2004","journal-title":"J Chem Eng Data"},{"key":"10.1002\/jps.22589_bb0275","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/ddr.10365","article-title":"Solubility studies on valdecoxib in the presence of carriers, cosolvents, and surfactants","volume":"62","author":"Desai","year":"2004","journal-title":"Drug Dev Res"},{"key":"10.1002\/jps.22589_bb0280","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1021\/je050190z","article-title":"Solubility of valdecoxib in the presence of glycerol, propylene glycol, and poly(ethylene glycol) 400 at (298.15, 303.15, and 308.15) K","volume":"50","author":"Liu","year":"2005","journal-title":"J Chem Eng Data"},{"key":"10.1002\/jps.22589_bb0285","first-page":"344","article-title":"Solubility of ibuprofen in some ethanol + water cosolvent mixtures at several temperatures","volume":"26","author":"Manrique","year":"2007","journal-title":"Lat Am J Pharm"},{"key":"10.1002\/jps.22589_bb0290","series-title":"Handbook of aqueous solubility data","author":"Yalkowsky","year":"2010"},{"key":"10.1002\/jps.22589_bb0295","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0378-5173(98)00263-4","article-title":"Partial solubility parameters of piroxicam and niflumic acid","volume":"174","author":"Bustamante","year":"1998","journal-title":"Int J Pharm"},{"key":"10.1002\/jps.22589_bb0300","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.molliq.2009.02.003","article-title":"Prediction of drug solubility in mixed solvents using computed Abraham parameters","volume":"146","author":"Jouyban","year":"2009","journal-title":"J Mol Liq"},{"key":"10.1002\/jps.22589_bb0305","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1248\/cpb.56.602","article-title":"Solubility prediction of paracetamol in water-ethanol-propylene glycol mixtures at 25 and 30\u00b0C using practical approaches","volume":"56","author":"Jouyban","year":"2008","journal-title":"Chem Pharm Bull"},{"key":"10.1002\/jps.22589_bb0310","doi-asserted-by":"crossref","unstructured":"Soltanpour S, Jouyban A. Solubility of acetaminophen and ibuprofen in polyethylene glycol 600, propylene glycol and water mixtures at 25\u00b0C J Mol Liq 155 80-84","DOI":"10.1016\/j.molliq.2010.05.011"},{"key":"10.1002\/jps.22589_bb0315","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1081\/DDC-100102287","article-title":"Solubilization of biphenyl dimethyl dicarboxylate by cosolvency","volume":"25","author":"Han","year":"1999","journal-title":"Drug Dev Ind Pharm"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002235491531892X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002235491531892X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T09:43:30Z","timestamp":1560246210000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002235491531892X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":62,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S002235491531892X"],"URL":"https:\/\/doi.org\/10.1002\/jps.22589","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}