{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:53:11Z","timestamp":1785325991236,"version":"3.55.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1002\/jps.22724","type":"journal-article","created":{"date-parts":[[2011,10,24]],"date-time":"2011-10-24T02:12:11Z","timestamp":1319422331000},"page":"5156-5173","source":"Crossref","is-referenced-by-count":32,"title":["Biophysical Characterization and Conformational Stability of Ebola and Marburg Virus-Like Particles"],"prefix":"10.1016","volume":"100","author":[{"given":"Lei","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared M.","family":"Trefethen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhong","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Yee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Ohtake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lechuga\u2010Ballesteros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly L.","family":"Warfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Javad","family":"Aman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Shulenin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Unfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven G.","family":"Enterlein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vu","family":"Truong\u2010Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Volkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangeeta B.","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Russell","family":"Middaugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1002\/jps.22724_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-3527(08)60733-2","article-title":"Marburg and Ebola viruses","volume":"47","author":"Feldmann","year":"1996","journal-title":"Adv Virus Res"},{"issue":"20","key":"10.1002\/jps.22724_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1462399404008300","article-title":"Ebola virus: New insights into disease aetiopathology and possible therapeutic interventions","volume":"6","author":"Geisbert","year":"2004","journal-title":"Expert Rev in Mol Med"},{"key":"10.1002\/jps.22724_bb0020","first-page":"1279","article-title":"Filoviridae: Marburg and Ebola viruses","volume":"1","author":"Sanchez","year":"2001","journal-title":"Fields virology"},{"issue":"8","key":"10.1002\/jps.22724_bb0025","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nri1154","article-title":"Ebola virus: From discovery to vaccine","volume":"3","author":"Feldmann","year":"2003","journal-title":"Nat Rev Immunol"},{"issue":"7068","key":"10.1002\/jps.22724_bb0030","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/438575a","article-title":"Fruit bats as reservoirs of Ebola virus","volume":"438","author":"Leroy","year":"2005","journal-title":"Nature"},{"issue":"7","key":"10.1002\/jps.22724_bb0035","doi-asserted-by":"crossref","first-page":"e1000536","DOI":"10.1371\/journal.ppat.1000536","article-title":"Isolation of genetically diverse Marburg viruses from Egyptian fruit bats","volume":"5","author":"Towner","year":"2009","journal-title":"PLoS Pathog"},{"issue":"8","key":"10.1002\/jps.22724_bb0040","doi-asserted-by":"crossref","first-page":"e764","DOI":"10.1371\/journal.pone.0000764","article-title":"Marburg virus infection detected in a common African bat","volume":"2","author":"Towner","year":"2007","journal-title":"PLoS One"},{"issue":"574","key":"10.1002\/jps.22724_bb0045","first-page":"542","article-title":"Marburg virus disease","volume":"49","author":"Martini","year":"1973","journal-title":"Br Med J"},{"issue":"18","key":"10.1002\/jps.22724_bb0050","doi-asserted-by":"crossref","first-page":"9733","DOI":"10.1128\/JVI.77.18.9733-9737.2003","article-title":"Ebola virus pathogenesis: Implications for vaccines and therapies","volume":"77","author":"Sullivan","year":"2003","journal-title":"J Virol"},{"issue":"3","key":"10.1002\/jps.22724_bb0055","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1089\/bsp.2004.2.186","article-title":"Marburg and Ebola viruses as aerosol threats","volume":"2","author":"Leffel","year":"2004","journal-title":"Biosecur and Bioterror"},{"issue":"18","key":"10.1002\/jps.22724_bb0060","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1001\/jama.287.18.2391","article-title":"Hemorrhagic fever viruses as biological weapons: Medical and public health management","volume":"287","author":"Borio","year":"2002","journal-title":"JAMA"},{"issue":"1\u20132","key":"10.1002\/jps.22724_bb0065","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0166-3542(02)00200-0","article-title":"Defense against filoviruses used as biological weapons","volume":"57","author":"Bray","year":"2003","journal-title":"Antiviral Res"},{"key":"10.1002\/jps.22724_bb0070","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1128\/9781555816971.ch14","article-title":"Are hemorrhagic fever viruses practical agents for biological terrorism","volume":"4","author":"Peters","year":"2000","journal-title":"Emerg Infec"},{"key":"10.1002\/jps.22724_bb0075","first-page":"169","article-title":"Hemorrhagic fever viruses as biological weapons","author":"Groseth","year":"2005"},{"issue":"2","key":"10.1002\/jps.22724_bb0080","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1099\/0022-1317-73-2-347","article-title":"Sequence analysis of the Marburg virus nucleoprotein gene: Comparison to Ebola virus and other non\u2010segmented negative\u2010strand RNA viruses","volume":"73","author":"Sanchez","year":"1992","journal-title":"J Gen Virol"},{"issue":"3","key":"10.1002\/jps.22724_bb0085","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0168-1702(93)90063-S","article-title":"Sequence analysis of the Ebola virus genome: Organization, genetic elements, and comparison with the genome of Marburg virus","volume":"29","author":"Sanchez","year":"1993","journal-title":"Virus Res"},{"issue":"5","key":"10.1002\/jps.22724_bb0090","doi-asserted-by":"crossref","first-page":"503","DOI":"10.3201\/eid0805.010284","article-title":"Evaluation in nonhuman primates of vaccines against Ebola virus","volume":"8","author":"Geisbert","year":"2002","journal-title":"Emerg Infect Dis"},{"issue":"5\u20136","key":"10.1002\/jps.22724_bb0095","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0020-7519(03)00064-X","article-title":"Vaccine research efforts for filoviruses","volume":"33","author":"Hart","year":"2003","journal-title":"Int J Parasitol"},{"issue":"3","key":"10.1002\/jps.22724_bb0100","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1586\/14760584.7.3.333","article-title":"Protection against filovirus infection: Virus\u2010like particle vaccines","volume":"7","author":"Yang","year":"2008","journal-title":"Expert Rev Vaccines"},{"issue":"9","key":"10.1002\/jps.22724_bb0105","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.2460\/javma.234.9.1130","article-title":"Filovirus infections","volume":"234","author":"Warfield","year":"2009","journal-title":"J Am Vet Med Assoc"},{"issue":"1","key":"10.1002\/jps.22724_bb0110","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1586\/erv.09.150","article-title":"Filovirus vaccines: What challenges are left","volume":"9","author":"Bukreyev","year":"2010","journal-title":"Expert Rev Vaccines"},{"issue":"3","key":"10.1002\/jps.22724_bb0115","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1586\/14760584.4.3.429","article-title":"Filovirus\u2010like particles as vaccines and discovery tools","volume":"4","author":"Warfield","year":"2005","journal-title":"Expert Rev Vaccines"},{"issue":"12","key":"10.1002\/jps.22724_bb0120","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/307178a0","article-title":"Human hepatitis B vaccine from recombinant yeast","volume":"307","author":"McAleer","year":"1984","journal-title":"Nature"},{"issue":"6","key":"10.1002\/jps.22724_bb0125","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.copbio.2004.10.002","article-title":"Virus\u2010like particles as vaccines and vessels for the delivery of small molecules","volume":"15","author":"Garcea","year":"2004","journal-title":"Curr Opin Biotechnol"},{"issue":"19","key":"10.1002\/jps.22724_bb0130","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1056\/NEJMoa061760","article-title":"Quadrivalent vaccine against human papillomavirus to prevent anogenital diseases","volume":"356","author":"Garland","year":"2007","journal-title":"N Engl J Med"},{"issue":"26","key":"10.1002\/jps.22724_bb0135","doi-asserted-by":"crossref","first-page":"15889","DOI":"10.1073\/pnas.2237038100","article-title":"Ebola virus\u2010like particles protect from lethal Ebola virus infection","volume":"100","author":"Warfield","year":"2003","journal-title":"Proc Nat Acad Sci U S A"},{"issue":"25\u201326","key":"10.1002\/jps.22724_bb0140","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.1016\/j.vaccine.2004.01.063","article-title":"Marburg virus\u2010like particles protect guinea pigs from lethal Marburg virus infection","volume":"22","author":"Warfield","year":"2004","journal-title":"Vaccine"},{"issue":"2","key":"10.1002\/jps.22724_bb0145","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.4049\/jimmunol.175.2.1184","article-title":"Induction of humoral and CD8+ T cell responses are required for protection against lethal Ebola virus infection","volume":"175","author":"Warfield","year":"2005","journal-title":"J Immunol"},{"issue":"23","key":"10.1002\/jps.22724_bb0150","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1016\/j.vaccine.2004.11.070","article-title":"Virus\u2010like particles exhibit potential as a pan\u2010filovirus vaccine for both Ebola and Marburg viral infections","volume":"23","author":"Swenson","year":"2005","journal-title":"Vaccine"},{"key":"10.1002\/jps.22724_bb0155","doi-asserted-by":"crossref","first-page":"S421","DOI":"10.1086\/520612","article-title":"Filovirus like particles produced in insect cells: Immunogenicity and protection in rodents","volume":"196","author":"Warfield","year":"2007","journal-title":"J Infect Dis"},{"key":"10.1002\/jps.22724_bb0160","doi-asserted-by":"crossref","first-page":"S430","DOI":"10.1086\/520583","article-title":"Ebola virus like particle\u2010based vaccine protects nonhuman primates against lethal Ebola virus challenge","volume":"196","author":"Warfield","year":"2007","journal-title":"J Infect Dis"},{"issue":"1","key":"10.1002\/jps.22724_bb0165","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.virol.2008.09.020","article-title":"Protection against lethal challenge by Ebola virus\u2010like particles produced in insect cells","volume":"383","author":"Sun","year":"2009","journal-title":"Virology"},{"issue":"5","key":"10.1002\/jps.22724_bb0170","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1084\/jem.20011500","article-title":"Lipid raft microdomains","volume":"195","author":"Bavari","year":"2002","journal-title":"J Exp Med"},{"issue":"1","key":"10.1002\/jps.22724_bb0175","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0928-8244(03)00273-6","article-title":"Generation of Marburg virus\u2010like particles by co\u2010expression of glycoprotein and matrix protein1","volume":"40","author":"Swenson","year":"2004","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"14","key":"10.1002\/jps.22724_bb0180","doi-asserted-by":"crossref","first-page":"7344","DOI":"10.1128\/JVI.78.14.7344-7351.2004","article-title":"Contribution of Ebola virus glycoprotein, nucleoprotein, and VP24 to budding of VP40 virus\u2010like particles","volume":"78","author":"Licata","year":"2004","journal-title":"J Virol"},{"issue":"2","key":"10.1002\/jps.22724_bb0185","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.virol.2006.03.021","article-title":"Ebola virus\u2010like particles produced in insect cells exhibit dendritic cell stimulating activity and induce neutralizing antibodies","volume":"351","author":"Ye","year":"2006","journal-title":"Virology"},{"issue":"1","key":"10.1002\/jps.22724_bb0190","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.virol.2005.09.018","article-title":"Filovirus assembly and budding","volume":"344","author":"Hartlieb","year":"2006","journal-title":"Virology"},{"issue":"1","key":"10.1002\/jps.22724_bb0195","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1586\/14760584.1.1.101","article-title":"Virus\u2010like particles: A new family of delivery systems","volume":"1","author":"Boisg\u00e9rault","year":"2002","journal-title":"Expert Rev Vaccines"},{"issue":"9","key":"10.1002\/jps.22724_bb0200","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1002\/jps.10439","article-title":"Derivative absorbance spectroscopy and protein phase diagrams as tools for comprehensive protein characterization: A bGCSF case study","volume":"92","author":"Kueltzo","year":"2003","journal-title":"J Pharm Sci"},{"issue":"28","key":"10.1002\/jps.22724_bb0205","doi-asserted-by":"crossref","first-page":"19478","DOI":"10.1074\/jbc.M603313200","article-title":"Conformational stability and disassembly of Norwalk virus\u2010like particles","volume":"281","author":"Ausar","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1002\/jps.22724_bb0210","doi-asserted-by":"crossref","unstructured":"Kissmann J, Joshi SB, Haynes JR, Dokken L, Richardson C, Middaugh CRH1N1 H1N1 influenza virus like particles: Physical degradation pathways and identification of stabilizers J Pharm Sci 100 2 634-645","DOI":"10.1002\/jps.22304"},{"issue":"8","key":"10.1002\/jps.22724_bb0215","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.1128\/JVI.80.8.3743-3751.2006","article-title":"Functional mapping of the nucleoprotein of Ebola virus","volume":"80","author":"Watanabe","year":"2006","journal-title":"J Virol"},{"issue":"6","key":"10.1002\/jps.22724_bb0220","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1099\/vir.0.019794-0","article-title":"Characterization of the Ebola virus nucleoprotein\u2013RNA complex","volume":"91","author":"Noda","year":"2010","journal-title":"J Gen Virol"},{"issue":"2","key":"10.1002\/jps.22724_bb0225","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1006\/viro.2002.1433","article-title":"Morphology of Marburg virus NP\u2013RNA","volume":"296","author":"Mavrakis","year":"2002","journal-title":"Virology"},{"issue":"7201","key":"10.1002\/jps.22724_bb0230","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nature07082","article-title":"Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor","volume":"454","author":"Lee","year":"2008","journal-title":"Nature"},{"issue":"6","key":"10.1002\/jps.22724_bb0235","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1073\/pnas.96.6.2662","article-title":"Core structure of the envelope glycoprotein GP2 from Ebola virus at 1.9\u2010\u00c5 resolution","volume":"96","author":"Malashkevich","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"21","key":"10.1002\/jps.22724_bb0240","doi-asserted-by":"crossref","first-page":"10194","DOI":"10.1128\/JVI.74.21.10194-10201.2000","article-title":"Functional importance of the coiled\u2010coil of the Ebola virus glycoprotein","volume":"74","author":"Watanabe","year":"2000","journal-title":"J Virol"},{"issue":"16","key":"10.1002\/jps.22724_bb0245","doi-asserted-by":"crossref","first-page":"4228","DOI":"10.1093\/emboj\/19.16.4228","article-title":"Crystal structure of the matrix protein VP40 from Ebola virus","volume":"19","author":"Dessen","year":"2000","journal-title":"EMBO J"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354915318098?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354915318098?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T09:25:47Z","timestamp":1560849947000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354915318098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":48,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S0022354915318098"],"URL":"https:\/\/doi.org\/10.1002\/jps.22724","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}