{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:35:52Z","timestamp":1778279752540,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1002\/jps.23195","type":"journal-article","created":{"date-parts":[[2012,5,11]],"date-time":"2012-05-11T19:09:43Z","timestamp":1336763383000},"page":"3547-3552","source":"Crossref","is-referenced-by-count":24,"title":["Comparative canine Pharmacokinetics\u2013Pharmacodynamics of Fospropofol Disodium Injection, Propofol Eemulsion, and Cyclodextrin-Enabled Propofol Solution Following Bolus Parenteral Administration"],"prefix":"10.1016","volume":"101","author":[{"given":"Michelle P.","family":"Mcintosh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger A.","family":"Rajewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1002\/jps.23195_bb0010","article-title":"Procedural sedation with propofol: A retrospective review of the experiences of an emergency medicine residency program 2005 to 2010","author":"McGrane","year":"2011","journal-title":"Am J Emerg Med"},{"key":"10.1002\/jps.23195_bb0015","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/978-3-540-74806-9_11","article-title":"Propofol","volume":"182","author":"Vanlersberghe","year":"2008","journal-title":"Handb Exp Pharmacol"},{"key":"10.1002\/jps.23195_bb0020","doi-asserted-by":"crossref","first-page":"d1110","DOI":"10.1136\/bmj.d1110","article-title":"Prevention of pain on injection of propofol: Systematic review and meta-analysis","volume":"342","author":"Jalota","year":"2011","journal-title":"BMJ"},{"issue":"5","key":"10.1002\/jps.23195_bb0025","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1046\/j.1365-2044.1998.00405.x","article-title":"Pain on injection of propofol","volume":"53","author":"Tan","year":"1998","journal-title":"Anaesthesia"},{"issue":"4","key":"10.1002\/jps.23195_bb0030","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1097\/00000539-200204000-00058","article-title":"Propofol formulation and pain on injection","volume":"94","author":"White","year":"2002","journal-title":"Anesth Analg"},{"issue":"4 Suppl","key":"10.1002\/jps.23195_bb0035","first-page":"S3","article-title":"Adverse events in a multicenter phase IV study of propofol: Evaluation by anesthesiologists and postanesthesia care unit nurses","volume":"77","author":"McLeskey","year":"1993","journal-title":"Anesth Analg"},{"issue":"4","key":"10.1002\/jps.23195_bb0040","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1021\/js970178s","article-title":"Inclusion complexation of propofol with 2-hydroxypropyl-beta-cyclodextrin. Physicochemical, nuclear magnetic resonance spectroscopic studies, and anesthetic properties in rat. trapani@ippo.uniba.it","volume":"87","author":"Trapani","year":"1998","journal-title":"J Pharm Sci"},{"issue":"1","key":"10.1002\/jps.23195_bb0045","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1213\/01.ANE.0000066019.42467.7A","article-title":"The pharmacokinetics and pharmacodynamics of propofol in a modified cyclodextrin formulation (Captisol) versus propofol in a lipid formulation (Diprivan): An electroencephalographic and hemodynamic study in a porcine model","volume":"97","author":"Egan","year":"2003","journal-title":"Anesth Analg"},{"key":"10.1002\/jps.23195_bb0050","author":"Meadows","year":"2003","journal-title":"Formulations of propofol"},{"key":"10.1002\/jps.23195_bb0055","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1517\/13543776.14.3.277","article-title":"Prodrugs as therapeutics","volume":"14","author":"Stella","year":"2004","journal-title":"Expert Opin Ther Patents"},{"issue":"1","key":"10.1002\/jps.23195_bb0060","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0928-0987(03)00161-1","article-title":"Highly water-soluble derivatives of the anesthetic agent propofol: In vitro and in vivo evaluation of cyclic amino acid esters","volume":"20","author":"Altomare","year":"2003","journal-title":"Eur J Pharm Sci"},{"key":"10.1002\/jps.23195_bb0065","author":"Hendler","year":"2001","journal-title":"Water soluble pro-drugs of propofol"},{"issue":"4","key":"10.1002\/jps.23195_bb0070","doi-asserted-by":"crossref","first-page":"469","DOI":"10.2165\/11204450-000000000-00000","article-title":"Fospropofol","volume":"70","author":"Garnock-Jones","year":"2010","journal-title":"Drugs"},{"issue":"10","key":"10.1002\/jps.23195_bb0075","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1517\/13543780903193063","article-title":"Fospropofol disodium, a water-soluble prodrug of the intravenous anesthetic propofol (2,6-diisopropylphenol)","volume":"18","author":"Fechner","year":"2009","journal-title":"Expert Opin Invest Drugs"},{"issue":"4","key":"10.1002\/jps.23195_bb0080","first-page":"301","article-title":"New drug, fospropofol disodium: A propofol prodrug","volume":"77","author":"Welliver","year":"2009","journal-title":"AANA J"},{"issue":"11","key":"10.1002\/jps.23195_bb0085","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1345\/aph.1M290","article-title":"Fospropofol: A new sedative-hypnotic agent for monitored anesthesia care","volume":"43","author":"Moore","year":"2009","journal-title":"Ann Pharmacother"},{"issue":"4","key":"10.1002\/jps.23195_bb0090","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1213\/ANE.0b013e3181d82560","article-title":"Requested retraction of six studies on the PK\/PD and tolerability of fospropofol","volume":"110","author":"Struys","year":"2010","journal-title":"Anesth Analg"},{"issue":"4","key":"10.1002\/jps.23195_bb0095","first-page":"1058","article-title":"Retraction. Comparative pharmacokinetics and pharmacodynamics of the new propofol prodrug GPI 15715 and propofol emulsion","volume":"112","author":"Fechner","year":"2010","journal-title":"Anesthesiology"},{"issue":"4","key":"10.1002\/jps.23195_bb0100","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1097\/EJA.0b013e3283382014","article-title":"Requested retraction of six studies on the PK\/PD and tolerability of fospropofol","volume":"27","author":"Struys","year":"2010","journal-title":"Eur J Anaesthesiol"},{"issue":"4","key":"10.1002\/jps.23195_bb0105","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1213\/ANE.0b013e31822b8648","article-title":"Propofol in a modified cyclodextrin formulation: First human study of dose\u2013response with emphasis on injection pain","volume":"113","author":"Wallentine","year":"2011","journal-title":"Anesth Analg"},{"key":"10.1002\/jps.23195_bb0110","unstructured":"Stella VJ, Zygmunt JJ, Georg IG, Safadi MS. Water-soluble prodrugs of hindered alcohols. Patent US6204257; US6451776; US6872838; US72447182000."},{"issue":"1","key":"10.1002\/jps.23195_bb0115","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0378-4347(87)80394-8","article-title":"Improved method for the determination of propofol in blood by high-performance liquid chromatography with fluorescence detection","volume":"421","author":"Plummer","year":"1987","journal-title":"J Chromatogr"},{"key":"10.1002\/jps.23195_bb0120","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1146\/annurev.pa.32.040192.002231","article-title":"Pharmacodynamic modeling of anesthetic EEG drug effects","volume":"32","author":"Stanski","year":"1992","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"6","key":"10.1002\/jps.23195_bb0125","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1109\/TAC.1974.1100705","article-title":"A new look at the statistical model identification","volume":"19","author":"Akaike","year":"1974","journal-title":"Automatic Control, IEEE Transactions on"},{"key":"10.1002\/jps.23195_bb0130","series-title":"Model selection and multimodel inference: A practical information-theoretic approach","author":"Burnham","year":"2002"},{"key":"10.1002\/jps.23195_bb0135","series-title":"Pharmacokinetics","author":"Gibaldi","year":"1982"},{"issue":"3","key":"10.1002\/jps.23195_bb0140","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1097\/00000542-199809000-00018","article-title":"Formulation-dependent brain and lung distribution kinetics of propofol in rats","volume":"89","author":"Dutta","year":"1998","journal-title":"Anesthesiology"},{"issue":"1","key":"10.1002\/jps.23195_bb0145","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.2042-7158.1998.tb03302.x","article-title":"Formulation-dependent pharmacokinetics and pharmacodynamics of propofol in rats","volume":"50","author":"Dutta","year":"1998","journal-title":"J Pharm Pharmacol"},{"issue":"3","key":"10.1002\/jps.23195_bb0150","first-page":"472","article-title":"Reducing pain during propofol injection: The role of the solvent","volume":"82","author":"Doenicke","year":"1996","journal-title":"Anesth Analg"},{"issue":"6","key":"10.1002\/jps.23195_bb0155","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1213\/00000539-199712000-00040","article-title":"Pharmacokinetics and pharmacodynamics of propofol in a new solvent","volume":"85","author":"Doenicke","year":"1997","journal-title":"Anesth Analg"},{"issue":"3","key":"10.1002\/jps.23195_bb0160","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1365-2125.2008.03358.x","article-title":"Pain on injection with microemulsion propofol","volume":"67","author":"Sim","year":"2009","journal-title":"Br J Clin Pharmacol"},{"key":"10.1002\/jps.23195_bb0165","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/978-3-540-74806-9_12","article-title":"Pharmacokinetics and pharmacodynamics of GPI 15715 or fospropofol (Aquavan injection)\u2014A water-soluble propofol prodrug","volume":"182","author":"Fechner","year":"2008","journal-title":"Handb Exp Pharmacol"},{"issue":"3","key":"10.1002\/jps.23195_bb0170","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3109\/00498259209046648","article-title":"The pharmacokinetics of propofol in laboratory animals","volume":"22","author":"Cockshott","year":"1992","journal-title":"Xenobiotica"},{"issue":"5","key":"10.1002\/jps.23195_bb0175","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/j.1528-1157.1990.tb06111.x","article-title":"Absolute bioavailability of phenytoin after 3-phosphoryloxymethyl phenytoin disodium (ACC-9653) administration to humans","volume":"31","author":"Jamerson","year":"1990","journal-title":"Epilepsia"},{"issue":"1","key":"10.1002\/jps.23195_bb0180","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2165\/00003088-200342010-00002","article-title":"Fosphenytoin: Clinical pharmacokinetics and comparative advantages in the acute treatment of seizures","volume":"42","author":"Fischer","year":"2003","journal-title":"Clin Pharmacokinet"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354915314544?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354915314544?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T12:00:13Z","timestamp":1561723213000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354915314544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0022354915314544"],"URL":"https:\/\/doi.org\/10.1002\/jps.23195","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}