{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:18:08Z","timestamp":1759961888359,"version":"3.44.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpharmsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1002\/jps.23294","type":"journal-article","created":{"date-parts":[[2012,8,21]],"date-time":"2012-08-21T18:13:17Z","timestamp":1345572797000},"page":"4118-4128","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Comparison of the Structural Stability and Dynamic Properties of Recombinant Anthrax Protective Antigen and its 2-Fluorohistidine-Labeled Analogue"],"prefix":"10.1016","volume":"101","author":[{"given":"Lei","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangeeta B.","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiran K.","family":"Andra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santosh V.","family":"Thakkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David B.","family":"Volkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James G.","family":"Bann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Russell","family":"Middaugh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1002\/jps.23294_bb0010","first-page":"CD006403","article-title":"Vaccines for preventing anthrax","volume":"2","author":"Donegan","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"issue":"17","key":"10.1002\/jps.23294_bb0015","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1001\/jama.287.17.2236","article-title":"Anthrax as a biological weapon, 2002","volume":"287","author":"Inglesby","year":"2002","journal-title":"JAMA"},{"issue":"6860","key":"10.1002\/jps.23294_bb0020","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/n35101999","article-title":"Identification of the cellular receptor for anthrax toxin","volume":"414","author":"Bradley","year":"2001","journal-title":"Nature"},{"issue":"9","key":"10.1002\/jps.23294_bb0025","doi-asserted-by":"crossref","first-page":"5170","DOI":"10.1073\/pnas.0431098100","article-title":"Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor","volume":"100","author":"Scobie","year":"2003","journal-title":"Proc Natl Acad Sci"},{"issue":"9","key":"10.1002\/jps.23294_bb0030","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/j.addr.2005.01.028","article-title":"Molecular basis for improved anthrax vaccines","volume":"57","author":"Brey","year":"2005","journal-title":"Adv Drug Del Rev"},{"key":"10.1002\/jps.23294_bb0035","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/385833a0","article-title":"Crystal structure of the anthrax toxin protective antigen","volume":"85","author":"Petosa","year":"1997","journal-title":"Nature"},{"issue":"10","key":"10.1002\/jps.23294_bb0040","doi-asserted-by":"crossref","first-page":"7045","DOI":"10.1073\/pnas.052160199","article-title":"The lethal and edema factors of anthrax toxin bind only to oligomeric forms of the protective antigen","volume":"99","author":"Mogridge","year":"2002","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"10.1002\/jps.23294_bb0045","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev.cellbio.19.111301.140655","article-title":"Anthrax toxin","volume":"19","author":"Collier","year":"2003","journal-title":"Annu Rev Cell Dev Biol"},{"issue":"1","key":"10.1002\/jps.23294_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/pro.752","article-title":"Anthrax toxin protective antigen\u2014Insights into molecular switching from prepore to pore","volume":"21","author":"Bann","year":"2012","journal-title":"Protein Sci"},{"issue":"1","key":"10.1002\/jps.23294_bb0055","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0006-291X(02)02771-7","article-title":"Exchange characteristics of calcium ions bound to anthrax protective antigen","volume":"300","author":"Gao-Sheridan","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"issue":"rr06","key":"10.1002\/jps.23294_bb0060","first-page":"1","article-title":"Use of anthrax vaccine in the United States","volume":"59","author":"Wright","year":"2010","journal-title":"Morbid Mortal Wkly Rep"},{"issue":"51","key":"10.1002\/jps.23294_bb0065","doi-asserted-by":"crossref","first-page":"14928","DOI":"10.1021\/bi701763z","article-title":"Effect of 2-fluorohistidine labeling of the anthrax protective antigen on stability, pore formation, and translocation","volume":"46","author":"Wimalasena","year":"2007","journal-title":"Biochemistry"},{"key":"10.1002\/jps.23294_bb0070","doi-asserted-by":"crossref","first-page":"6973","DOI":"10.1021\/bi100647z","article-title":"Evidence that histidine protonation of receptor-bound anthrax protective antigen is a trigger for pore formation","volume":"49","author":"Wimalasena","year":"2010","journal-title":"Biochemistry"},{"issue":"12","key":"10.1002\/jps.23294_bb0075","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1002\/cbic.200500249","article-title":"Biosynthetic incorporation of fluorohistidine into proteins in E. coli: a new probe of macromolecular structure","volume":"6","author":"Eichler","year":"2005","journal-title":"Chem Bio Chem"},{"key":"10.1002\/jps.23294_bb0080","doi-asserted-by":"crossref","first-page":"9399","DOI":"10.1021\/ac201995c","article-title":"Investigation of protein conformational stability employing a multimodal spectrometer","volume":"83","author":"Hu","year":"2011","journal-title":"Anal Chem"},{"issue":"9","key":"10.1002\/jps.23294_bb0085","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1002\/jps.10439","article-title":"Derivative absorbance spectroscopy and protein phase diagrams as tools for comprehensive protein characterization: A bGCSF case study","volume":"92","author":"Kueltzo","year":"2003","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.23294_bb0090","doi-asserted-by":"crossref","first-page":"4171","DOI":"10.1002\/jps.22618","article-title":"Multidimensional methods for the formulation of biopharmaceuticals and vaccines","volume":"100","author":"Maddux","year":"2011","journal-title":"J Pharm Sci"},{"issue":"7","key":"10.1002\/jps.23294_bb0095","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1002\/jps.21619","article-title":"Using empirical phase diagrams to understand the role of intramolecular dynamics in immunoglobulin G stability","volume":"98","author":"Ramsey","year":"2009","journal-title":"J Pharm Sci"},{"issue":"1","key":"10.1002\/jps.23294_bb0100","first-page":"113","article-title":"Aromatic contributions to circular dichroism spectra of protein","volume":"2","author":"Strickland","year":"1974","journal-title":"Crit Rev Biochem Mol Biol"},{"issue":"4","key":"10.1002\/jps.23294_bb0105","doi-asserted-by":"crossref","first-page":"349","DOI":"10.2174\/1389203003381315","article-title":"The use of circular dichroism in the investigation of protein structure and function","volume":"1","author":"Kelly","year":"2000","journal-title":"Curr Protein Pept Sci"},{"issue":"7","key":"10.1002\/jps.23294_bb0110","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1007\/s11095-007-9516-9","article-title":"Extrinsic fluorescent dyes as tools for protein characterization","volume":"25","author":"Hawe","year":"2008","journal-title":"Pharm Res"},{"issue":"1","key":"10.1002\/jps.23294_bb0115","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev.bb.20.060191.001541","article-title":"Ultrasonic velocimetry of biological compounds","volume":"20","author":"Sarvazyan","year":"1991","journal-title":"Annu Rev Biophys Biophys Chem"},{"issue":"1","key":"10.1002\/jps.23294_bb0120","first-page":"20","article-title":"Ultrasonic spectroscopy for materials analysis: Recent advances","volume":"15","author":"Buckin","year":"2003","journal-title":"Spectrosc Europe"},{"issue":"3","key":"10.1002\/jps.23294_bb0125","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1073\/pnas.80.3.750","article-title":"Adiabatic compressibility of globular proteins","volume":"80","author":"Gavish","year":"1983","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"13","key":"10.1002\/jps.23294_bb0130","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1021\/bi00308a026","article-title":"Red-edge excitation of fluorescence and dynamic properties of proteins and membranes","volume":"23","author":"Lakowicz","year":"1984","journal-title":"Biochemistry"},{"issue":"1","key":"10.1002\/jps.23294_bb0135","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/bio.671","article-title":"The red-edge effects: 30 years of exploration","volume":"17","author":"Demchenko","year":"2002","journal-title":"Luminescence"},{"issue":"7","key":"10.1002\/jps.23294_bb0140","doi-asserted-by":"crossref","first-page":"R153","DOI":"10.1016\/S1074-5521(00)00139-3","article-title":"Towards the nonstick egg: designing fluorous proteins","volume":"7","author":"Neil","year":"2000","journal-title":"Chem Biol"},{"issue":"3","key":"10.1002\/jps.23294_bb0145","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1016\/S0006-3495(04)74252-6","article-title":"Hydration dynamics near a model protein surface","volume":"86","author":"Russo","year":"2004","journal-title":"Biophys J"},{"issue":"26","key":"10.1002\/jps.23294_bb0150","doi-asserted-by":"crossref","first-page":"12966","DOI":"10.1021\/jp051137k","article-title":"Molecular view of water dynamics near model peptides","volume":"109","author":"Russo","year":"2005","journal-title":"J Phys Chem B"},{"issue":"6","key":"10.1002\/jps.23294_bb0155","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1093\/protein\/1.6.477","article-title":"Relationship of protein flexibility to thermostability","volume":"1","author":"Vihinen","year":"1987","journal-title":"Protein Eng"},{"issue":"2","key":"10.1002\/jps.23294_bb0160","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1080\/07391102.1998.10508256","article-title":"Native protein fluctuations: the conformational-motion temperature and the inverse correlation of protein flexibility with protein stability","volume":"16","author":"Tang","year":"1998","journal-title":"J Biomol Struct Dyn"},{"issue":"13","key":"10.1002\/jps.23294_bb0165","doi-asserted-by":"crossref","first-page":"7406","DOI":"10.1073\/pnas.95.13.7406","article-title":"Adjustment of conformational flexibility is a key event in the thermal adaptation of proteins","volume":"95","author":"ZAvodszky","year":"1998","journal-title":"Proc Natl Acad Sci"},{"issue":"7","key":"10.1002\/jps.23294_bb0170","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1073\/pnas.97.7.3166","article-title":"Millisecond time scale conformational flexibility in a hyperthermophile protein at ambient temperature","volume":"97","author":"Hern\u00e1ndez","year":"2000","journal-title":"Proc Natl Acad Sci"},{"issue":"19","key":"10.1002\/jps.23294_bb0175","doi-asserted-by":"crossref","first-page":"5582","DOI":"10.1021\/bi030005j","article-title":"Solution structure, dynamics, and thermodynamics of the native state ensemble of the Sem-5 C-terminal SH3 domain","volume":"42","author":"Ferreon","year":"2003","journal-title":"Biochemistry"},{"issue":"1","key":"10.1002\/jps.23294_bb0180","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0014-5793(04)00247-9","article-title":"An alternate conformation of the hyperthermostable HU protein from Thermotoga maritima has unexpectedly high flexibility","volume":"563","author":"Durney","year":"2004","journal-title":"FEBS Lett"},{"issue":"3","key":"10.1002\/jps.23294_bb0185","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/prot.20594","article-title":"Enhanced thermal stability achieved without increased conformational rigidity at physiological temperatures: Spatial propagation of differential flexibility in rubredoxin hybrids","volume":"61","author":"LeMaster","year":"2005","journal-title":"Proteins"},{"issue":"9","key":"10.1002\/jps.23294_bb0190","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.1002\/jps.21269","article-title":"The complex inter-relationships between protein flexibility and stability","volume":"97","author":"Kamerzell","year":"2008","journal-title":"J Pharm Sci"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354915313460?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354915313460?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:22:56Z","timestamp":1758360176000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354915313460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":37,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S0022354915313460"],"URL":"https:\/\/doi.org\/10.1002\/jps.23294","relation":{},"ISSN":["0022-3549"],"issn-type":[{"type":"print","value":"0022-3549"}],"subject":[],"published":{"date-parts":[[2012,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of the Structural Stability and Dynamic Properties of Recombinant Anthrax Protective Antigen and its 2-Fluorohistidine-Labeled Analogue","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1002\/jps.23294","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Wiley Periodicals, Inc. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}