{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T06:30:13Z","timestamp":1769581813540,"version":"3.49.0"},"reference-count":18,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1002\/jps.23833","type":"journal-article","created":{"date-parts":[[2014,1,6]],"date-time":"2014-01-06T22:34:45Z","timestamp":1389047685000},"page":"392-394","source":"Crossref","is-referenced-by-count":30,"title":["Inversion of Population Distribution of Felodipine Conformations at Increased Concentration in Dimethyl Sulfoxide Is a Prerequisite to Crystal Nucleation"],"prefix":"10.1016","volume":"103","author":[{"given":"Ilya A.","family":"Khodov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey V.","family":"Efimov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael YU.","family":"Nikiforov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir V.","family":"Klochkov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaj","family":"Georgi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1002\/jps.23833_bb0001","first-page":"388","article-title":"Pharmacokinetics and haemodynamic effects of felodipine as monotherapy in hypertensive patients","volume":"10","author":"Edgar","year":"1987","journal-title":"Clin Invest Med"},{"key":"10.1002\/jps.23833_bb0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-5173(92)90221-M","article-title":"Investigation of felodipine polymorphism and its glassy state","volume":"87","author":"Srcic","year":"1992","journal-title":"Int J Pharm"},{"key":"10.1002\/jps.23833_bb0003","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1002\/jps.1046","article-title":"Polymorphism of racemic felodipine and the unusual series of solid solutions in the binary system of its enantiomers","volume":"90","author":"Rollinger","year":"2001","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.23833_bb0004","doi-asserted-by":"crossref","first-page":"4022","DOI":"10.1021\/cg300501u","article-title":"Crystallization and polymorphism of felodipine","volume":"12","author":"Surov","year":"2012","journal-title":"Cryst Growth Des"},{"key":"10.1002\/jps.23833_bb0005","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1039\/C0CC04114A","article-title":"High precision NOEs as a probe for low level conformers\u2014A second conformation of strychnine","volume":"47","author":"Butts","year":"2011","journal-title":"Chem Commun"},{"key":"10.1002\/jps.23833_bb0006","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.molstruc.2012.11.040","article-title":"Spatial structure of felodipine dissolved in DMSO by 1D and 2D NOESY NMR spectroscopy","volume":"1035","author":"Khodov","year":"2013","journal-title":"J Mol Struct"},{"issue":"1","key":"10.1002\/jps.23833_bb0007","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/mrc.3905","article-title":"MSpin-RDC. A program for the use of residual dipolar couplings for structure elucidation of small molecules","volume":"50","author":"Navarro-V\u00e1zquez","year":"2012","journal-title":"Magn Reson Chem"},{"key":"10.1002\/jps.23833_bb0008","doi-asserted-by":"crossref","first-page":"9023","DOI":"10.1039\/c2cc32144k","article-title":"Accurate NOE-distance determination enables the stereochemical assignment of a flexible molecule\u2013arugosin C","volume":"48","author":"Butts","year":"2012","journal-title":"Chem Commun"},{"key":"10.1002\/jps.23833_bb0009","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.theochem.2006.09.016","article-title":"Theoretical study of hydrogen bond interactions of felodipine with polyvinylpyrrolidone and polyethyleneglycol","volume":"803","author":"Teberekidis","year":"2007","journal-title":"J Mol Struct (Theochem)"},{"key":"10.1002\/jps.23833_bb0010","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3762\/bjoc.7.20","article-title":"Accuracy in determining interproton distances using nuclear overhauser effect data from a flexible molecule","volume":"7","author":"Jones","year":"2011","journal-title":"Beilstein J Org Chem"},{"key":"10.1002\/jps.23833_bb0011","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/BF00203828","article-title":"Suppression of spin diffusion in selected frequency bands of nuclear overhauser spectra","volume":"7","author":"Vincent","year":"1996","journal-title":"J Biomol NMR"},{"key":"10.1002\/jps.23833_bb0012","doi-asserted-by":"crossref","first-page":"3938","DOI":"10.1002\/anie.200351947","article-title":"Elimination of zero-quantum interference in two-dimensional NMR spectra","volume":"42","author":"Thrippleton","year":"2003","journal-title":"Angew Chem Int Ed"},{"key":"10.1002\/jps.23833_bb0013","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1021\/ja00080a041","article-title":"Quenching spin diffusion in selective measurements of transient overhauser effects in nuclear magnetic resonance. Applications to oligonucleotides","volume":"116","author":"Zwahlen","year":"1994","journal-title":"J Am Chem Soc"},{"key":"10.1002\/jps.23833_bb0014","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1006\/jmra.1996.0222","article-title":"Gradient-selected NOESY\u2014A fourfold reduction of the measurement time for the NOESY experiment","volume":"123","author":"Wagner","year":"1996","journal-title":"J Magn Reson (Ser A)"},{"key":"10.1002\/jps.23833_bb0015","first-page":"207","article-title":"Practical aspects of two-dimensional transverse NOE spectroscopy","volume":"63","author":"Bax","year":"1985","journal-title":"J Magn Reson"},{"key":"10.1002\/jps.23833_bb0016","doi-asserted-by":"crossref","first-page":"8886","DOI":"10.1002\/chem.200900507","article-title":"Conformational flexibility and dynamics of two (1?6)-linked disaccharides related to an oligosaccharide epitope expressed on malignant tumour cells","volume":"15","author":"Olsson","year":"2009","journal-title":"Chem Eur J"},{"key":"10.1002\/jps.23833_bb0017","doi-asserted-by":"crossref","first-page":"6035","DOI":"10.1063\/1.439059","article-title":"Dipolar relaxation and nuclear overhauser effects in nonrigid molecules: The effect of fluctuating internuclear distances","volume":"72","author":"Tropp","year":"1980","journal-title":"J Chem Phys"},{"key":"10.1002\/jps.23833_bb0018","first-page":"36","article-title":"Influence of conformational exchange on the 2D NOESY spectra of biomolecules existing in multiple conformations","volume":"98","author":"Lee","year":"1992","journal-title":"J Magn Reson"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354915307279?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354915307279?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,7]],"date-time":"2018-10-07T16:27:57Z","timestamp":1538929677000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354915307279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S0022354915307279"],"URL":"https:\/\/doi.org\/10.1002\/jps.23833","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]}}}