{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:51:11Z","timestamp":1789696271518,"version":"4.0.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1002\/jps.23887","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T00:23:57Z","timestamp":1391559837000},"page":"1178-1183","source":"Crossref","is-referenced-by-count":16,"title":["Controlled-release injectable containing Terbinafine\/PLGA microspheres for Onychomycosis Treatment"],"prefix":"10.1016","volume":"103","author":[{"given":"Muralikrishnan","family":"Angamuthu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivakumar H.","family":"Nanjappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijayasankar","family":"Raman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seongbong","family":"Jo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phaniraj","family":"Cegu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Narasimha Murthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1002\/jps.23887_bb0001","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1128\/CMR.11.3.415","article-title":"Onychomycosis: Pathogenesis, diagnosis, and management","volume":"11","author":"Elewski","year":"1998","journal-title":"Clin Microbiol Rev"},{"issue":"10","key":"10.1002\/jps.23887_bb0002","doi-asserted-by":"crossref","first-page":"983","DOI":"10.2165\/00019053-200119100-00002","article-title":"Which antifungal agent for onychomycosis? A pharmacoeconomic analysis","volume":"19","author":"Joish","year":"2001","journal-title":"Pharmacoeconomics"},{"key":"10.1002\/jps.23887_bb0003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2133.149.s65.4.x","article-title":"Epidemiology, clinical presentation and diagnosis of onychomycosis","volume":"149","author":"Faergemann","year":"2003","journal-title":"Br J Dermatol"},{"issue":"1","key":"10.1002\/jps.23887_bb0004","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1468-3083.2004.00988.x","article-title":"Topical antifungal drugs for the treatment of onychomycosis: An overview of current strategies for monotherapy and combination therapy","volume":"19","author":"Baran","year":"2005","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"4","key":"10.1002\/jps.23887_bb0005","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1046\/j.1365-2133.1998.02464.x","article-title":"Prevalence and epidemiology of toenail onychomycosis in diabetic subjects: A multicentre survey","volume":"139","author":"Gupta","year":"1998","journal-title":"Br J Dermatol"},{"issue":"5","key":"10.1002\/jps.23887_bb0006","first-page":"379","article-title":"The prevalence and management of onychomycosis in diabetic patients","volume":"10","author":"Gupta","year":"2000","journal-title":"Eur J Dermatol"},{"issue":"9","key":"10.1002\/jps.23887_bb0007","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1093\/milmed\/146.9.644","article-title":"The diabetic foot ulcer: A complex problem with a simple treatment approach","volume":"146","author":"Block","year":"1981","journal-title":"Mil Med"},{"issue":"1","key":"10.1002\/jps.23887_bb0008","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0733-8635(05)70420-4","article-title":"Current management of onychomycosis. An overview","volume":"15","author":"Gupta","year":"1997","journal-title":"Dermatol Clin"},{"key":"10.1002\/jps.23887_bb0009","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1757-1146-4-26","article-title":"Safety and efficacy of tinea pedis and onychomycosis treatment in people with diabetes: A systematic review","volume":"4","author":"Matricciani","year":"2011","journal-title":"J Foot Ankle Res"},{"issue":"1","key":"10.1002\/jps.23887_bb0010","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1046\/j.1365-2133.1998.02050.x","article-title":"Subungual dermatophytoma complicating dermatophyte onychomycosis","volume":"138","author":"Roberts","year":"1998","journal-title":"Br J Dermatol"},{"issue":"4","key":"10.1002\/jps.23887_bb0011","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1440-0960.1998.tb01477.x","article-title":"Factors that may affect the response of onychomycosis to oral antifungal therapy","volume":"39","author":"Gupta","year":"1998","journal-title":"Australas J Dermatol"},{"key":"10.1002\/jps.23887_bb0012","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1046\/j.1365-2133.149.s65.2.x","article-title":"Combination therapy for onychomycosis","volume":"149","author":"Olafsson","year":"2003","journal-title":"Br J Dermatol"},{"issue":"7","key":"10.1002\/jps.23887_bb0013","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1002\/jps.23139","article-title":"Iontophoresis across the proximal nail fold to target drugs to the nail matrix","volume":"101","author":"Manda","year":"2012","journal-title":"J Pharm Sci"},{"issue":"10","key":"10.1002\/jps.23887_bb0014","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.3109\/03639045.2011.568946","article-title":"Transungual delivery of terbinafine by iontophoresis in onychomycotic nails","volume":"37","author":"Nair","year":"2011","journal-title":"Drug Dev Ind Pharm"},{"issue":"2","key":"10.1002\/jps.23887_bb0015","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1365-2230.1985.tb00537.x","article-title":"Tioconazole nail solution\u2014An open study of its efficacy in onychomycosis","volume":"10","author":"Hay","year":"1985","journal-title":"Clin Exp Dermatol"},{"issue":"10","key":"10.1002\/jps.23887_bb0016","doi-asserted-by":"crossref","first-page":"4267","DOI":"10.1002\/jps.22150","article-title":"Bilayered nail lacquer of terbinafine hydrochloride for treatment of onychomycosis","volume":"99","author":"Shivakumar","year":"2010","journal-title":"J Pharm Sci"},{"key":"10.1002\/jps.23887_bb0017","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1365-2230.1992.tb00281.x","article-title":"Amorolfine in the treatment of onychomycoses and dermatomycoses (an overview)","volume":"17","author":"Zaug","year":"1992","journal-title":"Clin Exp Dermatol"},{"issue":"8","key":"10.1002\/jps.23887_bb0018","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.ad.2011.03.013","article-title":"Intralesional infusion of methotrexate as neoadjuvant therapy improves the cosmetic and functional results of surgery to treat keratoacanthoma: Results of a randomized trial","volume":"102","author":"Martorell-Calatayud","year":"2011","journal-title":"Actas Dermosifiliogr"},{"issue":"9","key":"10.1002\/jps.23887_bb0019","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1097\/CJI.0b013e3181b2910f","article-title":"Intralesional lymphokine-activated killer cells as adjuvant therapy for primary glioblastoma","volume":"32","author":"Dillman","year":"2009","journal-title":"J Immunother"},{"issue":"2","key":"10.1002\/jps.23887_bb0020","doi-asserted-by":"crossref","first-page":"61","DOI":"10.4253\/wjge.v2.i2.61","article-title":"Intralesional steroid injection therapy in the management of resistant gastrointestinal strictures","volume":"2","author":"Kochhar","year":"2010","journal-title":"World J Gastrointest Endosc"},{"issue":"3","key":"10.1002\/jps.23887_bb0021","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/01.jsm.0000164039.91787.dc","article-title":"Intralesional corticosteroid injection versus extracorporeal shock wave therapy for plantar fasciopathy","volume":"15","author":"Porter","year":"2005","journal-title":"Clin J Sport Med"},{"issue":"4","key":"10.1002\/jps.23887_bb0022","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1097\/00005537-200204000-00019","article-title":"Intralesional cidofovir therapy for laryngeal papilloma in an adult cohort","volume":"112","author":"Bielamowicz","year":"2002","journal-title":"Laryngoscope"},{"issue":"4","key":"10.1002\/jps.23887_bb0023","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/jso.22029","article-title":"Local and intralesional therapy of in-transit melanoma metastases","volume":"104","author":"Testori","year":"2011","journal-title":"J Surg Oncol"},{"issue":"1","key":"10.1002\/jps.23887_bb0024","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1743-6109.2007.00651.x","article-title":"The use of intralesional clostridial collagenase injection therapy for Peyronie's disease: A prospective, single-center, non-placebo-controlled study","volume":"5","author":"Jordan","year":"2008","journal-title":"J Sex Med"},{"issue":"6","key":"10.1002\/jps.23887_bb0025","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1001\/archderm.138.6.811","article-title":"Oral treatments for toenail onychomycosis: A systematic review","volume":"138","author":"Crawford","year":"2002","journal-title":"Arch Dermatol"},{"issue":"4","key":"10.1002\/jps.23887_bb0026","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0927-7765(01)00205-3","article-title":"Development of biodegradable co-poly(d,l-lactic\/glycolic acid) microspheres for the controlled release of 5-FU by the spray drying method","volume":"25","author":"Fu","year":"2002","journal-title":"Colloids Surf B"},{"issue":"9","key":"10.1002\/jps.23887_bb0027","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1007\/s11095-009-9934-y","article-title":"An ex vivo toe model used to assess applicators for the iontophoretic ungual delivery of terbinafine","volume":"26","author":"Nair","year":"2009","journal-title":"Pharm Res"},{"issue":"1\u20132","key":"10.1002\/jps.23887_bb0028","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0378-5173(99)00394-4","article-title":"Diclofenac sodium incorporated PLGA (50:50) microspheres: Formulation considerations and in vitro\/in vivo evaluation","volume":"195","author":"Tuncay","year":"2000","journal-title":"Int J Pharm"},{"issue":"6","key":"10.1002\/jps.23887_bb0029","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1111\/j.0022-202X.2005.23927.x","article-title":"Immunology of the human nail apparatus: The nail matrix is a site of relative immune privilege","volume":"125","author":"Ito","year":"2005","journal-title":"J Invest Dermatol"},{"issue":"1\u20132","key":"10.1002\/jps.23887_bb0030","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ijpharm.2006.10.036","article-title":"Effect of WOW process parameters on morphology and burst release of FITC-dextran loaded PLGA microspheres","volume":"334","author":"Mao","year":"2007","journal-title":"Int J Pharm"},{"issue":"7","key":"10.1002\/jps.23887_bb0031","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/S0142-9612(01)00291-5","article-title":"Dexamethasone\/PLGA microspheres for continuous delivery of an anti-inflammatory drug for implantable medical devices","volume":"23","author":"Hickey","year":"2002","journal-title":"Biomaterials"},{"issue":"2\u20133","key":"10.1002\/jps.23887_bb0032","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0168-3659(01)00248-6","article-title":"On the importance and mechanisms of burst release in matrix-controlled drug delivery systems","volume":"73","author":"Huang","year":"2001","journal-title":"J Control Release"},{"issue":"3","key":"10.1002\/jps.23887_bb0033","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jconrel.2006.02.015","article-title":"Elevated temperature accelerated release testing of PLGA microspheres","volume":"112","author":"Zolnik","year":"2006","journal-title":"J Control Release"},{"issue":"2","key":"10.1002\/jps.23887_bb0034","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jconrel.2008.01.004","article-title":"Evaluation of in vivo-in vitro release of dexamethasone from PLGA microspheres","volume":"127","author":"Zolnik","year":"2008","journal-title":"J Control Release"},{"issue":"1","key":"10.1002\/jps.23887_bb0035","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1023\/A:1018971525301","article-title":"Controlled protein release from polyethyleneimine-coated poly(L-lactic acid)\/pluronic blend matrices","volume":"9","author":"Park","year":"1992","journal-title":"Pharm Res"},{"issue":"3","key":"10.1002\/jps.23887_bb0036","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3109\/02652049009021842","article-title":"Biodegradable poly(lactic acid) and poly(lactide-co-glycolide) microcapsules: Problems associated with preparative techniques and release properties","volume":"7","author":"Jalil","year":"1990","journal-title":"J Microencapsul"},{"key":"10.1002\/jps.23887_bb0037","first-page":"6112","article-title":"Reduced burst effect in drug release with solvent-treated microparticles prepared by the solvent evaporation method","volume":"27","author":"Ahmed","year":"2000","journal-title":"Control Release Bioact Mater"},{"issue":"1","key":"10.1002\/jps.23887_bb0038","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1021\/ma00027a019","article-title":"Poly (L-lactic acid)\/pluronic blends: Characterization of phase separation behavior, degradation, and morphology and use as protein-releasing matrixes","volume":"25","author":"Park","year":"1992","journal-title":"Macromolecules"},{"issue":"1","key":"10.1002\/jps.23887_bb0039","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0168-3659(00)00227-3","article-title":"Lysozyme distribution and conformation in a biodegradable polymer matrix as determined by FTIR techniques","volume":"68","author":"van de Weert","year":"2000","journal-title":"J Control Release"},{"issue":"1","key":"10.1002\/jps.23887_bb0040","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0168-3659(00)00291-1","article-title":"Effect of preparation temperature on the characteristics and release profiles of PLGA microspheres containing protein fabricated by double-emulsion solvent extraction\/evaporation method","volume":"69","author":"Yang","year":"2000","journal-title":"J Control Release"},{"issue":"1","key":"10.1002\/jps.23887_bb0041","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0168-3659(91)90127-Y","article-title":"Influence of formulation methods on the in vitro controlled release of protein from poly (ester) microspheres","volume":"17","author":"Wang","year":"1991","journal-title":"J Control Release"},{"issue":"11","key":"10.1002\/jps.23887_bb0042","doi-asserted-by":"crossref","first-page":"4130","DOI":"10.1002\/jps.21711","article-title":"Ungual and trans-ungual iontophoretic delivery of terbinafine for the treatment of onychomycosis","volume":"98","author":"Nair","year":"2009","journal-title":"J Pharm Sci"},{"issue":"21","key":"10.1002\/jps.23887_bb0043","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.1016\/S0142-9612(02)00170-9","article-title":"Why degradable polymers undergo surface erosion or bulk erosion","volume":"23","author":"von Burkersroda","year":"2002","journal-title":"Biomaterials"},{"issue":"7457","key":"10.1002\/jps.23887_bb0044","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nature12214","article-title":"Wnt activation in nail epithelium couples nail growth to digit regeneration","volume":"499","author":"Takeo","year":"2013","journal-title":"Nature"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354915306353?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354915306353?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T09:36:54Z","timestamp":1565170614000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354915306353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S0022354915306353"],"URL":"https:\/\/doi.org\/10.1002\/jps.23887","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]}}}