{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:18:15Z","timestamp":1790777895745,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1002\/jps.23968","type":"journal-article","created":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T13:50:47Z","timestamp":1396533047000},"page":"1720-1733","source":"Crossref","is-referenced-by-count":82,"title":["Multifunctional Medicated Lyophilised Wafer Dressing for Effective Chronic Wound Healing"],"prefix":"10.1016","volume":"103","author":[{"given":"Harshavardhan V.","family":"Pawar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua S.","family":"Boateng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Ayensu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Tetteh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1002\/jps.23968_bb0005","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1002\/jps.21210","article-title":"Wound healing dressings and drug delivery systems: A review","volume":"97","author":"Boateng","year":"2008","journal-title":"J Pharm Sci"},{"issue":"9","key":"10.1002\/jps.23968_bb0010","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.mpsur.2010.05.007","article-title":"Basic science of wound healing","volume":"28","author":"Beldon","year":"2010","journal-title":"Surgery (Oxford)"},{"issue":"2","key":"10.1002\/jps.23968_bb0015","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.mpsur.2007.11.005","article-title":"Basic science of wound healing","volume":"26","author":"Enoch","year":"2008","journal-title":"Surgery (Oxford)"},{"key":"10.1002\/jps.23968_bb0020","series-title":"Biofilm infections","first-page":"11","article-title":"Chronic wound colonization, infection, and biofilms","author":"Kirketerp-Moller","year":"2011"},{"issue":"7330","key":"10.1002\/jps.23968_bb0025","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1136\/bmj.324.7330.160","article-title":"Science, medicine, and the future\u2014Healing chronic wounds","volume":"324","author":"Harding","year":"2002","journal-title":"Br Med J"},{"issue":"6","key":"10.1002\/jps.23968_bb0030","doi-asserted-by":"crossref","first-page":"227","DOI":"10.12968\/jowc.2004.13.6.26625","article-title":"Moist wound healing: A concept that changed our practice","volume":"13","author":"Bryan","year":"2004","journal-title":"J Wound Care"},{"issue":"2","key":"10.1002\/jps.23968_bb0035","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S1040-0486(01)70038-5","article-title":"Wound dressings at the turn of the millennium","volume":"13","author":"Menaker","year":"2001","journal-title":"Curr Probl Dermatol"},{"issue":"3","key":"10.1002\/jps.23968_bb0040","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.12968\/bjcn.2010.15.Sup1.46907","article-title":"Managing wound exudate and promoting healing","volume":"15","author":"Adderley","year":"2010","journal-title":"Br J Community Nurs"},{"issue":"2","key":"10.1002\/jps.23968_bb0045","first-page":"14","article-title":"Antibacterial activity and scanning electron microscopy (SEM) examination of alginate-based films and wound dressings","volume":"18","author":"Pielesz","year":"2011","journal-title":"Ecol Chem Eng S"},{"issue":"3","key":"10.1002\/jps.23968_bb0050","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0144-8617(98)00077-0","article-title":"Carbohydrate polymers as wound management aids","volume":"37","author":"Lloyd","year":"1998","journal-title":"Carbohydr Polym"},{"issue":"9","key":"10.1002\/jps.23968_bb0055","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.progpolymsci.2011.05.003","article-title":"Current research on the blends of natural and synthetic polymers as new biomaterials: Review","volume":"36","author":"Sionkowska","year":"2011","journal-title":"Prog Polym Sci"},{"key":"10.1002\/jps.23968_bb0060","doi-asserted-by":"crossref","first-page":"102110","DOI":"10.1016\/j.colsurfb.2012.08.014","article-title":"Preparation, optimisation and characterisation of novel wound healing film dressings loaded with streptomycin and diclofenac","volume":"102","author":"Pawar","year":"2013","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"1-2","key":"10.1002\/jps.23968_bb0065","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ijpharm.2004.10.022","article-title":"Lyophilised wafers as a drug delivery system for wound healing containing methylcellulose as a viscosity modifier","volume":"289","author":"Matthews","year":"2005","journal-title":"Int J Pharm"},{"key":"10.1002\/jps.23968_bb0070","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.colsurfb.2011.11.004","article-title":"Development and physico-mechanical characterisation of lyophilised chitosan wafers as potential protein drug delivery systems via the buccal mucosa","volume":"91","author":"AyensuI","year":"2012","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"1-2","key":"10.1002\/jps.23968_bb0075","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ijpharm.2007.12.043","article-title":"Formulation, stability and thermal analysis of lyophilised wound healing wafers containing an insoluble MMP-3 inhibitor and a non-ionic surfactant","volume":"356","author":"Matthews","year":"2008","journal-title":"Int J Pharm"},{"issue":"1-2","key":"10.1002\/jps.23968_bb0080","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ijpharm.2006.01.023","article-title":"Gamma-irradiation of lyophilised wound healing wafers","volume":"313","author":"Matthews","year":"2006","journal-title":"Int J Pharm"},{"issue":"4","key":"10.1002\/jps.23968_bb0085","doi-asserted-by":"crossref","first-page":"443","DOI":"10.4155\/tde.12.27","article-title":"In vitro efficacy of antimicrobial wafers against methicillin-resistant Staphylococcus aureus","volume":"3","author":"Labovitiadi","year":"2012","journal-title":"Ther Deliv"},{"issue":"1-2","key":"10.1002\/jps.23968_bb0090","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ijpharm.2010.01.008","article-title":"Characterisation of freeze-dried wafers and solvent evaporated films as potential drug delivery systems to mucosal surfaces","volume":"389","author":"Boateng","year":"2010","journal-title":"Int J Pharm"},{"issue":"1-2","key":"10.1002\/jps.23968_bb0095","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ijpharm.2012.11.045","article-title":"Polyox and carrageenan based composite film dressing containing anti-microbial and antiinflammatory drugs for effective wound healing","volume":"441","author":"Boateng","year":"2013","journal-title":"Int J Pharm"},{"key":"10.1002\/jps.23968_bb0100","series-title":"Poster Symposium of Advance Wound Care (SAWC) 2010","article-title":"The silver release profile of antimicrobial wound dressings: Standardizing in vitro evaluations","author":"Lindsay","year":"2010"},{"issue":"3","key":"10.1002\/jps.23968_bb0105","first-page":"52","article-title":"The significance of surface pH in chronic wounds","volume":"3","author":"Gethin","year":"2007","journal-title":"Wounds UK"},{"issue":"4","key":"10.1002\/jps.23968_bb0110","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1002\/mabi.200800179","article-title":"Novel gelling systems of kappa-, iota- and lambda-Carrageenans and their composite gels with cellulose using ionic liquid","volume":"9","author":"Prasad","year":"2009","journal-title":"Macromol Biosci"},{"issue":"1","key":"10.1002\/jps.23968_bb0115","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ijpharm.2008.07.033","article-title":"Electrospun nanofibrous polymeric scaffold with targeted drug release profiles for potential application as wound dressing","volume":"364","author":"Thakur","year":"2008","journal-title":"Int J Pharm"},{"key":"10.1002\/jps.23968_bb0120","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1021\/bk-2010-1054.ch006","article-title":"Development of kappa- Carrageenan Poly (acrylic acid) interpenetrating network hydrogel as wound dressing patch","volume":"1054","author":"Dalafu","year":"2010","journal-title":"Biomaterials"},{"issue":"2","key":"10.1002\/jps.23968_bb0125","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.nimb.2006.11.101","article-title":"Role of natural polysaccharides in radiation formation of PVA-hydrogel wound dressing","volume":"255","author":"Varshney","year":"2007","journal-title":"Nucl Instrum Methods Phys Res Sect B Beam Interact With Mater And Atoms"},{"issue":"2","key":"10.1002\/jps.23968_bb0130","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1023\/B:PHAM.0000016234.73023.75","article-title":"Design of freeze-drying processes for pharmaceuticals: Practical advice","volume":"21","author":"Tang","year":"2004","journal-title":"Pharm Res"},{"issue":"1","key":"10.1002\/jps.23968_bb0135","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.carbpol.2007.11.005","article-title":"Novel thiolated carboxymethyl chitosan-g-beta-cyclodextrin as mucoadhesive hydrophobic drug delivery carriers","volume":"73","author":"Prabaharan","year":"2008","journal-title":"Carbohydr Polym"},{"issue":"5","key":"10.1002\/jps.23968_bb0140","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1021\/bm061140p","article-title":"Physical, mechanical, and antibacterial properties of chitosan\/PEO blend films","volume":"8","author":"Zivanovic","year":"2007","journal-title":"Biomacromolecules"},{"issue":"10","key":"10.1002\/jps.23968_bb0145","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1080\/03639040600832827","article-title":"Nifedipine molecular dispersion in microparticles of ammonio methacrylate copolymer and ethylcellulose binary blends for controlled drug delivery: Effect of matrix composition","volume":"32","author":"Huang","year":"2006","journal-title":"Drug Dev Ind Pharm"},{"issue":"8","key":"10.1002\/jps.23968_bb0150","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1021\/jp809294p","article-title":"Effect of sodium sulfate on the gelling behavior of agarose and water structure inside the gel networks","volume":"113","author":"Singh","year":"2009","journal-title":"J Phys Chem B"},{"issue":"8","key":"10.1002\/jps.23968_bb0155","first-page":"26","article-title":"Topical antimicrobials in the control of wound bioburden","volume":"52","author":"White","year":"2006","journal-title":"Ostomy Wound Manage"},{"issue":"9","key":"10.1002\/jps.23968_bb0160","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1086\/513277","article-title":"Staphylococcus aureus exploits cathelicidin antimicrobial peptides produced during early pneumonia to promote staphylokinase-dependent fibrinolysis","volume":"195","author":"Braff","year":"2007","journal-title":"J Infect Dis"},{"key":"10.1002\/jps.23968_bb0165","first-page":"2","article-title":"Key considerations when developing freeze-dried formulation and current trends","volume":"22","author":"Bunte","year":"2010","journal-title":"Pharm Technol Europe Digital"},{"issue":"2","key":"10.1002\/jps.23968_bb0170","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.ijpharm.2008.09.004","article-title":"Mathematical modeling of drug delivery","volume":"364","author":"Siepmann","year":"2008","journal-title":"Int J Pharm"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354915305578?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354915305578?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T01:49:11Z","timestamp":1565315351000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354915305578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["S0022354915305578"],"URL":"https:\/\/doi.org\/10.1002\/jps.23968","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]}}}