{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T04:04:42Z","timestamp":1754107482928},"reference-count":18,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[1976,11,1]],"date-time":"1976-11-01T00:00:00Z","timestamp":215654400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[1976,11]]},"DOI":"10.1002\/jps.2600651122","type":"journal-article","created":{"date-parts":[[2006,10,14]],"date-time":"2006-10-14T00:35:11Z","timestamp":1160786111000},"page":"1651-1654","source":"Crossref","is-referenced-by-count":18,"title":["Biotransformation of Drugs: Quantitative Structure\u2013Activity Relationships for Barbiturates, Tertiary Amines, and Substituted Imidazoles"],"prefix":"10.1016","volume":"65","author":[{"given":"George L.","family":"Tong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric J.","family":"Lien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1002\/jps.2600651122_bb0010","first-page":"427","article-title":"Ann. Reu. Biochem","volume":"27","author":"Brodie","year":"1958"},{"key":"10.1002\/jps.2600651122_bb0015","first-page":"89","article-title":"Biochem. Pharmacol","volume":"2","author":"Gaudette","year":"1959"},{"key":"10.1002\/jps.2600651122_bb0020","first-page":"1027","article-title":"J. Pharm. Sci","volume":"57","author":"Lien","year":"1968"},{"key":"10.1002\/jps.2600651122_bb0025","first-page":"139","article-title":"Arch. Biochem. Biophys","volume":"128","author":"Hansch","year":"1968"},{"key":"10.1002\/jps.2600651122_bb0030","first-page":"777","article-title":"J. Med. Chem","volume":"14","author":"Martin","year":"1971"},{"key":"10.1002\/jps.2600651122_bb0035","first-page":"1","article-title":"Drug Metab. Reu","volume":"1","author":"Hansch","year":"1972"},{"key":"10.1002\/jps.2600651122_bb0040","first-page":"391","article-title":"Arch. Biochem. Biophys","volume":"151","author":"Jannson","year":"1972"},{"key":"10.1002\/jps.2600651122_bb0045","series-title":"\u201cMicrosomes and Drug Oxidation\u201d","first-page":"173","author":"Ziegler","year":"1969"},{"key":"10.1002\/jps.2600651122_bb0050","first-page":"3187","article-title":"Biochem. Pharmacol","volume":"21","author":"Wilkinson","year":"1972"},{"key":"10.1002\/jps.2600651122_bb0055","first-page":"745","article-title":"J. Med. Chem","volume":"10","author":"Hansch","year":"1967"},{"key":"10.1002\/jps.2600651122_bb0060","first-page":"1341","article-title":"Science","volume":"176","author":"Levin","year":"1972"},{"key":"10.1002\/jps.2600651122_bb0065","first-page":"128","article-title":"Proc. Int. Congr. Pharmacol","volume":"4","author":"Hansch","year":"1969"},{"key":"10.1002\/jps.2600651122_bb0070","first-page":"271","article-title":"\u201cDrug Design\u201d","volume":"1","author":"Hansch","year":"1971"},{"key":"10.1002\/jps.2600651122_bb0075","series-title":"\u201cBiological Correlations\u2014The Hansch Approach\u201d","first-page":"20","author":"Hansch","year":"1972"},{"key":"10.1002\/jps.2600651122_bb0080","first-page":"525","article-title":"Chem. Reu","volume":"71","author":"Leo","year":"1972"},{"key":"10.1002\/jps.2600651122_bb0085","first-page":"251","article-title":"Cancer Chemother. Rep","volume":"57","author":"Lien","year":"1973"},{"key":"10.1002\/jps.2600651122_bb0090","first-page":"865","article-title":"J. Pharm. Sci","volume":"59","author":"Lien","year":"1970"},{"key":"10.1002\/jps.2600651122_bb0095","first-page":"1207","article-title":"J. Med. Chem","volume":"16","author":"Hansch","year":"1973"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354915390225?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354915390225?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,12]],"date-time":"2019-01-12T12:20:52Z","timestamp":1547295652000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354915390225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,11]]},"references-count":18,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1976,11]]}},"alternative-id":["S0022354915390225"],"URL":"https:\/\/doi.org\/10.1002\/jps.2600651122","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[1976,11]]}}}