{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T23:29:20Z","timestamp":1792279760023,"version":"4.4.0"},"reference-count":14,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1985,2,1]],"date-time":"1985-02-01T00:00:00Z","timestamp":476064000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[1985,2]]},"DOI":"10.1002\/jps.2600740202","type":"journal-article","created":{"date-parts":[[2006,10,14]],"date-time":"2006-10-14T20:43:09Z","timestamp":1160858589000},"page":"113-119","source":"Crossref","is-referenced-by-count":12,"title":["INTRAV and ORAL: BASIC Interactive Computer Programs for Estimating Pharmacokinetic Parameters"],"prefix":"10.1016","volume":"74","author":[{"given":"J.L.","family":"Valentine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1002\/jps.2600740202_bb001","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1002\/jps.2600671214","volume":"67","author":"Brown","year":"1978","journal-title":"J. Pharm Sci."},{"key":"10.1002\/jps.2600740202_bb002","first-page":"4","article-title":"\"Current Concepts in the Pharmaceutical Sciences: Biopharmaceutics\"","author":"Portmann","year":"1970"},{"key":"10.1002\/jps.2600740202_bb003","series-title":"\"Biopharmaceutics and Relevant Pharmacokinetics\"","first-page":"322","author":"Wagner","year":"1971"},{"key":"10.1002\/jps.2600740202_bb004","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1002\/jps.2600650713","volume":"65","author":"Sedman","year":"1976","journal-title":"J. Pharm. Sci."},{"key":"10.1002\/jps.2600740202_bb005","doi-asserted-by":"crossref","first-page":"562","DOI":"10.2307\/2529651","volume":"30","author":"Metzler","year":"1974","journal-title":"Biometrics"},{"key":"10.1002\/jps.2600740202_bb006","unstructured":"A copy of the program listings and\/or magnetic cassette tapes as well as a user's manual is available for a fee to cover reproduction cost."},{"key":"10.1002\/jps.2600740202_bb007","first-page":"15","article-title":"Symbols and equations for pharmacokinetic parameter determination throughout the text conform to those recommended by the American College of Clinical Pharmacology May 1982,","volume":"22","year":"1982","journal-title":"J. Clin. Pharmacol."},{"key":"10.1002\/jps.2600740202_bb008","first-page":"261","volume":"1","author":"Wagner","year":"1968","journal-title":"Int. J. Clin. Pharmacol."},{"key":"10.1002\/jps.2600740202_bb009","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/cpt196781part2201","volume":"8","author":"Wagner","year":"1967","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1002\/jps.2600740202_bb0010","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1080\/00032718208064387","volume":"15","author":"Valentine","year":"1982","journal-title":"Anal. Lett."},{"key":"10.1002\/jps.2600740202_bb0011","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/jps.2600590107","volume":"59","author":"Loo","year":"1970","journal-title":"J. Pharm. Sci."},{"key":"10.1002\/jps.2600740202_bb0012","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/bdd.2510030307","volume":"3","author":"Ruifrak","year":"1982","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1002\/jps.2600740202_bb0013","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/BF01060092","volume":"6","author":"Boxenbaum","year":"1978","journal-title":"J. Pharmacokinet. Biopharm."},{"key":"10.1002\/jps.2600740202_bb0014","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF01061504","volume":"2","author":"Boxenbaum","year":"1974","journal-title":"J. Pharmacok inet. Biopharm."}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354915465979?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354915465979?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,21]],"date-time":"2019-04-21T19:29:25Z","timestamp":1555874965000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354915465979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,2]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1985,2]]}},"alternative-id":["S0022354915465979"],"URL":"https:\/\/doi.org\/10.1002\/jps.2600740202","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[1985,2]]}}}