{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:09:07Z","timestamp":1790705347393,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1985,2,1]],"date-time":"1985-02-01T00:00:00Z","timestamp":476064000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[1985,2]]},"DOI":"10.1002\/jps.2600740210","type":"journal-article","created":{"date-parts":[[2006,10,14]],"date-time":"2006-10-14T20:43:09Z","timestamp":1160858589000},"page":"155-160","source":"Crossref","is-referenced-by-count":31,"title":["Topical Carbonic Anhydrase Inhibitors III: Optimization Model for Corneal Penetration of Ethoxzolamide Analogues"],"prefix":"10.1016","volume":"74","author":[{"given":"M.G.","family":"Eller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.D.","family":"Schoenwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.A.","family":"Dixson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Segarra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.F.","family":"Barfknecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1002\/jps.2600740210_bb001","series-title":"\"Strategy of Drug Design\"","author":"Purcell","year":"1973"},{"key":"10.1002\/jps.2600740210_bb002","series-title":"\"Quantitative Drug Design\"","author":"Martin","year":"1978"},{"key":"10.1002\/jps.2600740210_bb003","series-title":"\"Symposium of Ocular Therapy\"","volume":"10","author":"Mandell","year":"1977"},{"key":"10.1002\/jps.2600740210_bb004","first-page":"817","volume":"19","author":"Anderson","year":"1980","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"10.1002\/jps.2600740210_bb005","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/0002-9394(79)90142-9","volume":"87","author":"Kohn","year":"1979","journal-title":"Am. J. Ophthalmol."},{"key":"10.1002\/jps.2600740210_bb006","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/jps.2600680606","volume":"68","author":"Lee","year":"1979","journal-title":"J. Pharm. Sci."},{"key":"10.1002\/jps.2600740210_bb007","first-page":"55","article-title":"\"Ophthalmic Drug Delivery Systems\"","author":"Eriksen","year":"1980"},{"key":"10.1002\/jps.2600740210_bb008","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0378-5173(79)90023-1","volume":"2","author":"Mosher","year":"1979","journal-title":"Int. J. Pharm."},{"key":"10.1002\/jps.2600740210_bb009","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1002\/jps.2600670614","volume":"67","author":"Schoenwald","year":"1978","journal-title":"J. Pharm. Sci."},{"key":"10.1002\/jps.2600740210_bb0010","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1002\/jps.2600721109","volume":"72","author":"Huang","year":"1983","journal-title":"J. Pharm. Sci."},{"key":"10.1002\/jps.2600740210_bb0011","article-title":"\"Glaucoma Drug Therapy\"","author":"Leopold","year":"1981"},{"key":"10.1002\/jps.2600740210_bb0012","first-page":"730","volume":"16","author":"Maren","year":"1977","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"10.1002\/jps.2600740210_bb0013","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1001\/archopht.1977.04450100111014","volume":"95","author":"Friedman","year":"1977","journal-title":"Arch. Ophthalmol."},{"key":"10.1002\/jps.2600740210_bb0014","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1001\/archopht.1978.03910060521010","volume":"96","author":"Theeuwes","year":"1978","journal-title":"Arch. Ophthalmol."},{"key":"10.1002\/jps.2600740210_bb0015","first-page":"509","volume":"10","author":"Zimmerman","year":"1978","journal-title":"Annals Ophthalmol."},{"key":"10.1002\/jps.2600740210_bb0016","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/0002-9394(55)91276-9","volume":"39","author":"Foss","year":"1955","journal-title":"Am. J. Ophthalmol"},{"key":"10.1002\/jps.2600740210_bb0017","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S0002-9394(14)78041-9","volume":"47","author":"Becker","year":"1959","journal-title":"Am. J. Ophthalmol"},{"key":"10.1002\/jps.2600740210_bb0018","first-page":"802","volume":"18","author":"Wistrand","year":"1979","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"10.1002\/jps.2600740210_bb0019","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1001\/archopht.1978.03910060290023","volume":"96","author":"Marci","year":"1978","journal-title":"Arch. Ophthalmol."},{"key":"10.1002\/jps.2600740210_bb0020","first-page":"782","volume":"21","author":"L\u00f6tjen-Drecoll","year":"1981","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"10.1002\/jps.2600740210_bb0021","first-page":"867","volume":"18","author":"Dobbs","year":"1979","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"10.1002\/jps.2600740210_bb0022","doi-asserted-by":"crossref","first-page":"4893","DOI":"10.1021\/ja01167a012","volume":"72","author":"Miller","year":"1950","journal-title":"J. Am. Chem. Soc."},{"key":"10.1002\/jps.2600740210_bb0023","doi-asserted-by":"crossref","first-page":"4890","DOI":"10.1021\/ja01167a011","volume":"72","author":"Roblin","year":"1950","journal-title":"J. Am. Chem. Soc."},{"key":"10.1002\/jps.2600740210_bb0024","first-page":"385","volume":"117","author":"Maren","year":"1956","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1002\/jps.2600740210_bb0025","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/0002-9394(83)90017-X","volume":"95","author":"Stein","year":"1983","journal-title":"Am. J. Ophthalmol"},{"key":"10.1002\/jps.2600740210_bb0026","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0014-4835(83)90041-6","volume":"36","author":"Maren","year":"1983","journal-title":"Exp. Eye Res."},{"key":"10.1002\/jps.2600740210_bb0027","series-title":"\"Quantitative Drug Design\"","first-page":"61","author":"Martin","year":"1978"},{"key":"10.1002\/jps.2600740210_bb0028","first-page":"111","article-title":"\"Physical Chemical Properties of Drugs\"","author":"Coates","year":"1980"},{"key":"10.1002\/jps.2600740210_bb0029","unstructured":"Schoenwald, R. D.; Eller,-M. G.; Dixson, 3. A.; Barfmecht, C. F.J. Med. Chem., in press."},{"key":"10.1002\/jps.2600740210_bb0030","series-title":"Synthesis of Sulfonamide Carbonic Anhydrase Inhibitors for Glaucoma\"","author":"Dixson","year":"1983"},{"key":"10.1002\/jps.2600740210_bb0031","series-title":"\"The Determination of Ionization Constants\"","author":"Albert","year":"1971"},{"key":"10.1002\/jps.2600740210_bb0032","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1021\/cr60274a001","volume":"71","author":"Leo","year":"1971","journal-title":"Chem. Rev."},{"key":"10.1002\/jps.2600740210_bb0033","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0014-4835(71)90143-6","volume":"12","author":"Kim","year":"1971","journal-title":"Exp. Eye Res."},{"key":"10.1002\/jps.2600740210_bb0034","first-page":"201","article-title":"Physical Chemical Properties of Drugs","author":"Valvani","year":"1980"},{"key":"10.1002\/jps.2600740210_bb0035","series-title":"\"Physiology of the Eye\"","first-page":"114","author":"Fatt","year":"1978"},{"key":"10.1002\/jps.2600740210_bb0036","series-title":"\"Log P and Parameter Database\"","author":"Hansch","year":"1983"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354915465797?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354915465797?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,21]],"date-time":"2019-04-21T19:29:34Z","timestamp":1555874974000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354915465797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,2]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1985,2]]}},"alternative-id":["S0022354915465797"],"URL":"https:\/\/doi.org\/10.1002\/jps.2600740210","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[1985,2]]}}}