{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:25:23Z","timestamp":1759940723432},"reference-count":32,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[1989,7,1]],"date-time":"1989-07-01T00:00:00Z","timestamp":615254400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[1989,7]]},"DOI":"10.1002\/jps.2600780714","type":"journal-article","created":{"date-parts":[[2006,10,14]],"date-time":"2006-10-14T17:43:19Z","timestamp":1160847799000},"page":"577-581","source":"Crossref","is-referenced-by-count":28,"title":["Effects of Hydrotropic Agents on the Solubility, Precipitation, and Protein Binding of Etoposide"],"prefix":"10.1016","volume":"78","author":[{"given":"I.A.","family":"Darwish","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.T.","family":"Florence","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.M.","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1002\/jps.2600780714_bb0010","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1056\/NEJM198503143121106","volume":"312","author":"O'Dwyer","year":"1985","journal-title":"N. Engl. J. Med."},{"key":"10.1002\/jps.2600780714_bb0015","first-page":"112","volume":"2","author":"Phillips","year":"1985","journal-title":"Clin. Pharm."},{"key":"10.1002\/jps.2600780714_bb0020","article-title":"NCI Investigational Drugs-Pharmaceutical Data","year":"1983","journal-title":"U.S. Department of Health and Human Services"},{"key":"10.1002\/jps.2600780714_bb0025","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/0014-2964(75)90043-2","volume":"11","author":"Allen","year":"1975","journal-title":"Eur. J. Cancer"},{"key":"10.1002\/jps.2600780714_bb0030","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/0277-5379(86)90315-9","volume":"22","author":"Holthuis","year":"1986","journal-title":"Eur. J. Cancer Clin. Oncol."},{"key":"10.1002\/jps.2600780714_bb0035","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/cpt1975182221","volume":"18","author":"Creaven","year":"1975","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1002\/jps.2600780714_bb0040","first-page":"174","volume":"22","author":"Evans","year":"1981","journal-title":"Proc. Am. Assoc. Cancer Res. Am. Soc. Clin. Oncol."},{"key":"10.1002\/jps.2600780714_bb0045","first-page":"107","volume":"76","author":"Neuberg","year":"1916","journal-title":"Biochem. Z."},{"key":"10.1002\/jps.2600780714_bb0050","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1039\/TF9504600762","volume":"54","author":"Winsor","year":"1950","journal-title":"Trans. Faraday Soc."},{"key":"10.1002\/jps.2600780714_bb0055","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0378-5173(82)90143-0","volume":"13","author":"Badwan","year":"1983","journal-title":"Int. J. Pharm."},{"key":"10.1002\/jps.2600780714_bb0060","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0378-5173(85)90023-7","volume":"24","author":"Saleh","year":"1985","journal-title":"Int. J. Pharm."},{"key":"10.1002\/jps.2600780714_bb0065","series-title":"United States Pharmacopoeia Dictionary of Drug Names","first-page":"217","year":"1988"},{"key":"10.1002\/jps.2600780714_bb0070","author":"Peter","year":"1975"},{"key":"10.1002\/jps.2600780714_bb0075","first-page":"525","volume":"29","author":"Saleh","year":"1974","journal-title":"Pharmazie"},{"key":"10.1002\/jps.2600780714_bb0080","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1002\/jps.2600680620","volume":"68","author":"Poochikian","year":"1979","journal-title":"J. Pharm. Sci."},{"key":"10.1002\/jps.2600780714_bb0085","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0378-5173(83)90024-8","volume":"17","author":"Saleh","year":"1983","journal-title":"Int. J. Pharm."},{"key":"10.1002\/jps.2600780714_bb0090","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1749-6632.1946.tb31713.x","volume":"47","author":"Brand","year":"1946","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1002\/jps.2600780714_bb0095","first-page":"278","volume":"107","author":"Reynolds","year":"1960","journal-title":"Bull. Johns Hopkins Hosp."},{"key":"10.1002\/jps.2600780714_bb0100","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.2042-7158.1967.tb09600.x","volume":"19","author":"Sturman","year":"1967","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1002\/jps.2600780714_bb0105","first-page":"161","volume":"133","author":"Davison","year":"1961","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1002\/jps.2600780714_bb0110","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0378-5173(81)90060-0","volume":"7","author":"Nakano","year":"1981","journal-title":"Int. J. Pharm."},{"key":"10.1002\/jps.2600780714_bb0115","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/jps.2600650105","volume":"65","author":"Cruze","year":"1976","journal-title":"J. Pharm. Sci."},{"key":"10.1002\/jps.2600780714_bb0120","doi-asserted-by":"crossref","first-page":"3572","DOI":"10.1248\/cpb.26.3572","volume":"26","author":"Higashi","year":"1978","journal-title":"Chem. Pharm. Bull."},{"key":"10.1002\/jps.2600780714_bb0125","first-page":"51","volume":"35","author":"Goto","year":"1975","journal-title":"Yakuzaigaku"},{"key":"10.1002\/jps.2600780714_bb0130","first-page":"727","volume":"1","author":"Klotz","year":"1953"},{"key":"10.1002\/jps.2600780714_bb0135","first-page":"417","volume":"11","author":"Yalkowsky","year":"1977","journal-title":"Drag Intell. Clin. Pharm."},{"key":"10.1002\/jps.2600780714_bb0140","first-page":"669","volume":"35","author":"Movis","year":"1978","journal-title":"Am. J. Hosp. Pharm."},{"key":"10.1002\/jps.2600780714_bb0145","first-page":"104","volume":"39","author":"Korttila","year":"1976","journal-title":"Ada Pharm. Toxicol."},{"key":"10.1002\/jps.2600780714_bb0150","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1001\/jama.1973.03220020050018","volume":"223","author":"Langdon","year":"1973","journal-title":"J. Am. Med. Assoc."},{"key":"10.1002\/jps.2600780714_bb0155","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1213\/00000539-197705000-00020","volume":"56","author":"Graham","year":"1977","journal-title":"Curr. Res. Anesth. Analg."},{"key":"10.1002\/jps.2600780714_bb0160","first-page":"1","volume":"28","author":"Schroeder","year":"1974","journal-title":"Bull. Parenter. Drug Assoc."},{"key":"10.1002\/jps.2600780714_bb0165","first-page":"90","volume":"1","author":"Saleh","year":"1987","journal-title":"Alexandrian J. Pharm. Sci."}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354915480050?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354915480050?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,21]],"date-time":"2019-04-21T19:23:44Z","timestamp":1555874624000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354915480050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,7]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1989,7]]}},"alternative-id":["S0022354915480050"],"URL":"https:\/\/doi.org\/10.1002\/jps.2600780714","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[1989,7]]}}}