{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:15:06Z","timestamp":1792192506494,"version":"4.4.0"},"reference-count":18,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[1994,4,1]],"date-time":"1994-04-01T00:00:00Z","timestamp":765158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[1994,4]]},"DOI":"10.1002\/jps.2600830423","type":"journal-article","created":{"date-parts":[[2006,10,15]],"date-time":"2006-10-15T13:45:27Z","timestamp":1160919927000},"page":"559-561","source":"Crossref","is-referenced-by-count":4,"title":["Cyclosporine Enhances Theophylline Neurotoxicity in Rats"],"prefix":"10.1016","volume":"83","author":[{"given":"Amnon","family":"Hoffman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyne","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mishel","family":"Afargan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amichai","family":"Schattner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1002\/jps.2600830423_bb0005","series-title":"Drug Information 91","first-page":"2239","year":"1991"},{"issue":"14","key":"10.1002\/jps.2600830423_bb0010","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1056\/NEJM198710013171404","volume":"317","author":"De Groen","year":"1987","journal-title":"Engl. J. Med."},{"key":"10.1002\/jps.2600830423_bb0015","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2165\/00003495-198836010-00006","volume":"36","author":"McInnes","year":"1988","journal-title":"Drugs"},{"key":"10.1002\/jps.2600830423_bb0020","series-title":"Topics in Pharmaceutical Sciences 1987","first-page":"93","author":"Levy","year":"1987"},{"key":"10.1002\/jps.2600830423_bb0025","first-page":"708","volume":"236","author":"Ramzan","year":"1986","journal-title":"Pharmacol. Exp. Ther."},{"key":"10.1002\/jps.2600830423_bb0030","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1152\/jappl.1964.19.3.540","volume":"19","author":"Weeks","year":"1964","journal-title":"J. Appl. Physiol."},{"key":"10.1002\/jps.2600830423_bb0035","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/jps.2600790106","volume":"79","author":"Hoffman","year":"1990","journal-title":"J. Pharm. Sci."},{"key":"10.1002\/jps.2600830423_bb0040","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/0889-1591(88)90026-8","volume":"2","author":"Dougherty","year":"1988","journal-title":"Brain Behav. Immun."},{"issue":"24","key":"10.1002\/jps.2600830423_bb0045","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1056\/NEJM199106133242417","volume":"324","author":"Gottrand","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"10.1002\/jps.2600830423_bb0050","series-title":"The Pharmacological Basis of Therapeutics, 8th ed.; Gilman, A. G","first-page":"1264","author":"Handschumacher","year":"1990"},{"key":"10.1002\/jps.2600830423_bb0055","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1212\/WNL.25.9.819","volume":"25","author":"Yarnell","year":"1975","journal-title":"Neurology"},{"key":"10.1002\/jps.2600830423_bb0060","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S0140-6736(88)92037-5","volume":"28","author":"Kunzendorf","year":"1988","journal-title":"Lancet"},{"key":"10.1002\/jps.2600830423_bb0065","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0165-5728(87)90068-3","volume":"13","author":"Dougherty","year":"1987","journal-title":"J. Neuroimmun."},{"key":"10.1002\/jps.2600830423_bb0070","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0192-0561(87)90019-1","volume":"9","author":"Montgomery","year":"1987","journal-title":"Int. J. Immunopharmacol."},{"key":"10.1002\/jps.2600830423_bb0075","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/0028-3908(86)90003-1","volume":"25","author":"Dafny","year":"1986","journal-title":"Neuropharmacology"},{"key":"10.1002\/jps.2600830423_bb0080","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/S0140-6736(84)91556-3","volume":"17","author":"Thompson","year":"1984","journal-title":"Lancet"},{"key":"10.1002\/jps.2600830423_bb0085","first-page":"117","volume":"249","author":"Hoffman","year":"1989","journal-title":"J.Pharmacol. Exp. Ther."},{"key":"10.1002\/jps.2600830423_bb0090","first-page":"3173","volume":"23","author":"Freise","year":"1991","journal-title":"Transplant. Proc."}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354915494353?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354915494353?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,21]],"date-time":"2019-04-21T20:27:55Z","timestamp":1555878475000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354915494353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,4]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,4]]}},"alternative-id":["S0022354915494353"],"URL":"https:\/\/doi.org\/10.1002\/jps.2600830423","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[1994,4]]}}}