{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:20:41Z","timestamp":1759940441333},"reference-count":20,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1995,3,1]],"date-time":"1995-03-01T00:00:00Z","timestamp":794016000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[1995,3]]},"DOI":"10.1002\/jps.2600840310","type":"journal-article","created":{"date-parts":[[2006,10,15]],"date-time":"2006-10-15T16:05:18Z","timestamp":1160928318000},"page":"312-317","source":"Crossref","is-referenced-by-count":60,"title":["Mechanistic Studies of the 1\u2010Alkyl\u20102\u2010pyrrolidones as Skin Permeation Enhancers"],"prefix":"10.1016","volume":"84","author":[{"given":"Kunio","family":"Yoneto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdel\u2010Halim","family":"Ghanem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William I.","family":"Higuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kendall D.","family":"Peck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kevin Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1002\/jps.2600840310_bb0005","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0168-3659(87)90065-4","volume":"6","author":"Ghanem","year":"1987","journal-title":"J. Controlled Release"},{"key":"10.1002\/jps.2600840310_bb0010","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0378-5173(92)90365-9","volume":"78","author":"Ghanem","year":"1992","journal-title":"Int. J. Pharm."},{"key":"10.1002\/jps.2600840310_bb0015","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0378-5173(92)90258-4","volume":"80","author":"Kim","year":"1992","journal-title":"I.Int. J.Pharm"},{"key":"10.1002\/jps.2600840310_bb0020","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0378-5173(88)90095-6","volume":"44","author":"Sasaki","year":"1988","journal-title":"Int. J. Pharm."},{"key":"10.1002\/jps.2600840310_bb0025","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/jps.2600800606","volume":"80","author":"Sasaki","year":"1991","journal-title":"J.Pharm. Sci."},{"key":"10.1002\/jps.2600840310_bb0030","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0378-5173(90)90070-K","volume":"60","author":"Sasaki","year":"1990","journal-title":"Int. J. Pharm."},{"key":"10.1002\/jps.2600840310_bb0035","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1248\/bpb1978.13.200","volume":"13","author":"Sasaki","year":"1990","journal-title":"J.Pharmacobio. Dyn."},{"key":"10.1002\/jps.2600840310_bb0040","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1248\/bpb1978.13.468","volume":"13","author":"Sasaki","year":"1990","journal-title":"J.Pharmacobio. Dyn."},{"key":"10.1002\/jps.2600840310_bb0045","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1248\/cpb.36.1519","volume":"36","author":"Sugibayashi","year":"1988","journal-title":"Chem. Pharm. Bull."},{"key":"10.1002\/jps.2600840310_bb0050","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.2042-7158.1987.tb03173.x","volume":"39","author":"Barry","year":"1987","journal-title":"J.Pharm. Pharmacol."},{"key":"10.1002\/jps.2600840310_bb0055","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/jps.2600681105","volume":"68","author":"Yu","year":"1979","journal-title":"J.Pharm. Sci."},{"key":"10.1002\/jps.2600840310_bb0060","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1002\/aic.690270611","volume":"27","author":"Deen","year":"1981","journal-title":"AIChE J."},{"key":"10.1002\/jps.2600840310_bb0065","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1002\/aic.690330902","volume":"33","author":"Deen","year":"1987","journal-title":"AIChE J."},{"key":"10.1002\/jps.2600840310_bb0070","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1023\/A:1018998529283","volume":"11","author":"Peck","year":"1994","journal-title":"Pharm. Res"},{"key":"10.1002\/jps.2600840310_bb0075","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0006-3495(92)81581-3","volume":"63","author":"Xiang","year":"1992","journal-title":"Biophys. J."},{"key":"10.1002\/jps.2600840310_bb0080","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0006-3495(94)80833-1","volume":"66","author":"Xiang","year":"1994","journal-title":"Biophys. J."},{"key":"10.1002\/jps.2600840310_bb0085","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1002\/jps.2600831027","volume":"83","author":"Xiang","year":"1994","journal-title":"J.Pharm. Sci."},{"key":"10.1002\/jps.2600840310_bb0090","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/BF00232899","volume":"140","author":"Xiang","year":"1994","journal-title":"J.Membr. Biol."},{"key":"10.1002\/jps.2600840310_bb0095","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0005-2736(93)90171-U","volume":"1148","author":"Kim","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1002\/jps.2600840310_bb0100","first-page":"S","volume":"10","author":"Higuchi","year":"1993","journal-title":"Pharm. Res"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354915497497?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354915497497?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,21]],"date-time":"2019-04-21T20:31:12Z","timestamp":1555878672000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354915497497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,3]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,3]]}},"alternative-id":["S0022354915497497"],"URL":"https:\/\/doi.org\/10.1002\/jps.2600840310","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[1995,3]]}}}