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However, time\u2010resolved and longitudinal studies that examine in\u00a0vivo bioaccumulation and clearance remain limited. Here, we use surface\u2010enhanced Raman scattering (SERS) and surface\u2010enhanced infrared absorption (SEIRA) spectroscopies to detect and track the presence of two PAHs (pyrene and benzo[\n                    <jats:italic>a<\/jats:italic>\n                    ]pyrene) and one PAC (5,12\u2010naphthacenequinone), in murine organ tissues. Mice were exposed to a three\u2010component mixture of these three chemicals; then, their organs were collected at 24, 48, and 72\u2009h post exposure. The accumulation of each of these chemicals in the brain, liver, kidneys, heart, and spleen over a 72\u2010h postexposure period was determined by SERS and SEIRA and independently quantified by gas chromatography\u2013mass spectrometry (GC\u2013MS) analysis. The liver and kidneys displayed the highest level of accumulation, reflecting their important roles in detoxification, while significant levels were detected in the brain, indicating permeability of the blood\u2013brain barrier and the potential for neurotoxic effects. Benzo[\n                    <jats:italic>a<\/jats:italic>\n                    ]pyrene showed the highest retention and slowest clearance, while 5,12\u2010naphthacenequinone showed surprisingly minimal bioaccumulation. The independent detection of benzo[\n                    <jats:italic>a<\/jats:italic>\n                    ]pyrene\u2010induced DNA adducts in multiple organs also highlights its mutagenic and carcinogenic risk.\n                  <\/jats:p>","DOI":"10.1002\/jrs.70063","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T10:40:15Z","timestamp":1760006415000},"page":"1051-1060","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SERS and SEIRA Detection of Polycyclic Aromatic Hydrocarbons and Their Derivatives in Murine Tissues: Bioaccumulation and Clearance"],"prefix":"10.1002","volume":"57","author":[{"given":"Oara","family":"Neumann","sequence":"first","affiliation":[{"name":"Department of Electrical and Computer Engineering Rice University  Houston Texas USA"},{"name":"Department of Chemistry Rice University  Houston Texas USA"},{"name":"Laboratory for Nanophotonics Rice University  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s\u00a0B.","family":"S\u00e1nchez\u2010Alvarado","sequence":"additional","affiliation":[{"name":"Department of Chemistry Rice University  Houston Texas USA"},{"name":"Laboratory for Nanophotonics Rice University  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo\u00a0Dong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology Texas A&amp;M University Health Sciences  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin\u00a0B.","family":"Jorveka","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology Baylor College of Medicine  Houston Texas 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