{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:55:01Z","timestamp":1771473301917,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T00:00:00Z","timestamp":1571011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010414","name":"Health Research Board","doi-asserted-by":"publisher","award":["HRB RL2013\/4"],"award-info":[{"award-number":["HRB RL2013\/4"]}],"id":[{"id":"10.13039\/100010414","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Research Synthesis Methods"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>If IPD is available for some or all trials in a network meta\u2010analysis (NMA), then incorporating this IPD into an NMA is routinely considered to be preferable. However, the situation often arises where a researcher has IPD for trials concerning a particular treatment (eg, from a sponsor) but none for other trials. Therefore, one can reweight the IPD so that the covariate characteristics in the IPD trials match that of the aggregate data (AgD) trials, using a matching\u2010adjusted indirect comparison (MAIC). We assess the impact of using the reweighted aggregated data, obtained by the MAIC, in a Bayesian NMA for a connected treatment network. We apply this method to a network of multiple myeloma treatments in newly diagnosed patients (ndMM), where the outcome is progression free survival. We investigate the reliability of the methods and results through a simulation study. The ndMM network consists of three IPD studies comparing lenalidomide to placebo (Len\u2010Placebo), one AgD study comparing Len\u2010Placebo, and one AgD study comparing thalidomide to placebo (Thal\u2010Placebo). We therefore investigate two options of weighting the covariates: (a) All three studies are weighted separately to match the AgD Thal\u2010Placebo trial. (b) Patients are weighted across all three IPD studies to match the AgD Thal\u2010Placebo trial, but the NMA considers each trial separately. We observe limited benefit to MAIC in the full network population. While MAIC can be beneficial as a sensitivity analysis to confirm results across patient populations, we advise that MAIC is used and interpreted with caution.<\/jats:p>","DOI":"10.1002\/jrsm.1372","type":"journal-article","created":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T10:05:03Z","timestamp":1564653903000},"page":"546-568","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Assessing the impact of a matching\u2010adjusted indirect comparison in a Bayesian network meta\u2010analysis"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6567-9099","authenticated-orcid":false,"given":"Joy","family":"Leahy","sequence":"first","affiliation":[{"name":"School of Computer Science and Statistics Trinity College Dublin  Dublin Ireland"},{"name":"National Centre of Pharmacoeconomics St. James Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6599-9562","authenticated-orcid":false,"given":"Cathal","family":"Walsh","sequence":"additional","affiliation":[{"name":"National Centre of Pharmacoeconomics St. James Hospital  Dublin Ireland"},{"name":"Health Research Institute and MACSI, Department of Mathematics and Statistics University of Limerick  Limerick Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.331.7521.897"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/11538370-000000000-00000"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2012.05.004"},{"key":"e_1_2_10_5_1","unstructured":"PhillippoD AdesT DiasS PalmerS AbramsKR WeltonN.NICE DSU Technical Support Document 18: Methods for populationadjusted indirect comparisons in submissions to NICE. (Technical Support Documents). Decision Support Unit ScHARR University of Sheffield: NICE Decision Support Unit. 2016;2016."},{"issue":"1","key":"e_1_2_10_6_1","first-page":"13","article-title":"Matching\u2010adjusted indirect treatment comparison in patients with radioiodine\u2010refractory differentiated thyroid cancer","volume":"2016","author":"Tremblay G","year":"2016","journal-title":"Comp Eff Res"},{"key":"e_1_2_10_7_1","first-page":"1","article-title":"Comparative efficacy of ibrutinib versus obinutuzumab+ chlorambucil in first\u2010line treatment of chronic lymphocytic leukemia: a matching\u2010adjusted indirect comparison","author":"Van Sanden S","year":"2017","journal-title":"Adv Ther"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3414\/ME15-02-0016"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2015.03.196"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1114083"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1114138"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402888"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-357038"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","unstructured":"JacksonGH DaviesFE PawlynC et al.Response adapted induction treatment improves outcomes for myeloma patients; results of the phase iii myeloma xi study;2016.","DOI":"10.1182\/blood.V128.22.244.244"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.5584"},{"issue":"3","key":"e_1_2_10_16_1","doi-asserted-by":"crossref","first-page":"4410","DOI":"10.1002\/jrsm.1305","article-title":"The impact of individual patient data in a network meta analysis: an investigation into parameter estimation and model selection","volume":"9","author":"Leahy J","year":"2018","journal-title":"Res Synth Methods"},{"key":"e_1_2_10_17_1","unstructured":"SpiegelhalterD ThomasA BestN LunnD.Open\u2010BUGS User Manual;2014."},{"key":"e_1_2_10_18_1","unstructured":"PlummerM.Jags version 3.3. 0 user manual.2012."},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1214\/ss\/1177011136"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-10-54"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-105"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2014.12.012"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1368"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-12-167"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.2165\/11537420-000000000-00000"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2013.08.1782"},{"key":"e_1_2_10_27_1","unstructured":"AmandaS.Brigatinib (Alunbrig) as monotherapy for the first\u2010line treatment of adult patients with anaplastic lymphoma kinase (ALK)\u2010positive advanced non\u2010small cell lung cancer (NSCLC). PROSPERO 2018 CRD42018098664https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?RecordID=98664. Accessed: July 2019."},{"key":"e_1_2_10_28_1","unstructured":"SchmitzS BuchananV LeahyJ DhanasiriS PawlynC AshcroftJ.A systematic review and network meta\u2010analysis of maintenance treatment for patients with newly diagnosed multiple myeloma post\u2010autologous stem cell transplant;2017."}],"container-title":["Research Synthesis Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jrsm.1372","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jrsm.1372","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jrsm.1372","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T08:13:20Z","timestamp":1694160800000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jrsm.1372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,14]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1002\/jrsm.1372"],"URL":"https:\/\/doi.org\/10.1002\/jrsm.1372","archive":["Portico"],"relation":{},"ISSN":["1759-2879","1759-2887"],"issn-type":[{"value":"1759-2879","type":"print"},{"value":"1759-2887","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,14]]},"assertion":[{"value":"2018-06-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}