{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:48:35Z","timestamp":1786978115661,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2020,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Sweet corn cob (SCC), an agricultural by\u2010product of the corn\u2010processing industry, contains more than 80% insoluble bound ferulic acid (FA). Extraction of these bound phenolics can be achieved through chemical or enzymatic hydrolysis; however, the shift towards greener chemistry has raised awareness about the use of enzymatic hydrolysis. In the present study, the ability of ferulic acid esterase (FAE) and xylanase (XY) to catalyze the hydrolysis of FA from SCC was investigated. Response surface methodology (RSM), based on a five\u2010level, four\u2010factor central composite rotatable design (CCRD), was used to establish the optimum conditions for enzymatic hydrolysis of FA from SCC. Sweet corn cob was treated with a combination of FAE and XY at various concentrations (FAE: 0.00 to 0.04\u2009U\/g; XY: 0.00 to 18\u2009093.5\u00a0U\/g), temperatures (45 to 65 \u00b0C), and pH levels (pH\u00a04.5 to 6.5).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The optimum extraction conditions predicted by the model were: FAE concentration of 0.02\u2009U\/g, XY concentration of 3475.3\u00a0U\/g, extraction pH of 4.5, and an extraction temperature of 45\u2009\u00b0C.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      Under these conditions, the experimental yield of FA was 1.69\u2009\u00b1\u20090.02\u00a0g\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      of SCC, which is in agreement with the value predicted by the model. \u00a9 2019 Society of Chemical Industry\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.10155","type":"journal-article","created":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T16:59:38Z","timestamp":1574441978000},"page":"1479-1485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Optimization of enzyme\u2010assisted extraction of ferulic acid from sweet corn cob by response surface methodology"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2839-8375","authenticated-orcid":false,"given":"Tiffany","family":"Lau","sequence":"first","affiliation":[{"name":"Department of Food and Nutritional Sciences University of Reading  Reading UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niamh","family":"Harbourne","sequence":"additional","affiliation":[{"name":"UCD Institute of Food and Health, School of Agricultural and Food Science University College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria J","family":"Oru\u00f1a\u2010Concha","sequence":"additional","affiliation":[{"name":"Department of Food and Nutritional Sciences University of Reading  Reading UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biombioe.2003.08.002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2011.06.010"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.btre.2014.06.008"},{"key":"e_1_2_6_5_1","first-page":"764","article-title":"Rat housed on corn cob bedding show less slow\u2010wave sleep","volume":"51","author":"Leys LJ","year":"2012","journal-title":"J Am Assoc Lab Anim 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