{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:06:27Z","timestamp":1791389187086,"version":"4.3.3"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T00:00:00Z","timestamp":1579478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2020,3,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      A mouse model in which diabetes mellitus was induced by low\u2010dose streptozotocin (STZ) injection combined with a high\u2010fat diet was used to study the effect of two water cress (\n                      <jats:italic>Lepidium savitum<\/jats:italic>\n                      ) preparations. Diabetic mice were treated with dried cress powder or with water\u2010soluble extracts (tested at two doses), together with proper control groups. The mice were evaluated after 4\u2009weeks of continuous intervention for type 2 diabetic and associated markers. We determined blood glucose, body weight, total cholesterol (TC), triglyceride (TG), low\u2010density lipoprotein (LDL), high\u2010density lipoprotein (HDL), serum insulin levels, and DNA integrity of hepatic cells. The concentrations of malondialdehyde (MDA) and lipid peroxide (LPO) and the activities of four enzymes that are part of the antioxidant defense system were determined in liver samples, as well as gene expression (by semi\u2010quantitative reverse transcription polymerase chain reaction) and enzyme activity of IRS\u20101, IRS\u20102, PI3K, AKT\u20102, and GLUT4.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      After 4\u2009weeks of intervention, the levels of TC, TG, and LDL cholesterol were significantly (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.5) decreased and HDL cholesterol was significantly increased. Enzyme activities of liver superoxide dismutase, glutathione, glutathione peroxidase, and catalase were significantly increased, whereas MDA and LPO concentrations were significantly reduced. The transcription level of the five genes assessed was increased, with corresponding increases in protein expression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Oral uptake of garden cress can significantly reduce the blood glucose and improve the blood lipid metabolism of diabetic mice. Considerable improvements in the activity of antioxidant defense enzymes were observed in type 2 diabetic mice that improved the body's antioxidant emergency response. \u00a9 2019 Society of Chemical Industry<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.10230","type":"journal-article","created":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T03:25:56Z","timestamp":1577330756000},"page":"2074-2081","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Effect of garden cress in reducing blood glucose, improving blood lipids, and reducing oxidative stress in a mouse model of diabetes induced by a high\u2010fat diet and streptozotocin"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8103-6173","authenticated-orcid":false,"given":"Xi","family":"Chen","sequence":"first","affiliation":[{"name":"School of Food and Biological Engineering Hefei University of Technology  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaibo","family":"Yuan","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering Hefei University of Technology  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7315-7194","authenticated-orcid":false,"given":"Fangfang","family":"Shi","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering Hefei University of Technology  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7741-965X","authenticated-orcid":false,"given":"Yudong","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering Hefei University of Technology  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,20]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"Diabetes Prevention and Treatment Guideline in China","author":"Diabetes Society of Chinese Medical Association","year":"2004"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2005.1707"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1332633100"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00138-09"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2007.00782.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf204496f"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bionut.2013.06.002"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2013.11.001"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.11.033"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.11569\/wcjd.v16.i29.3310"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.6.1615"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-004-1391-x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-008-0739-2"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.08.014"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.18.6849-6859.2000"},{"key":"e_1_2_5_17_1","first-page":"59","article-title":"Research on the herbal watercress herb","volume":"32","author":"Huang Z","year":"2001","journal-title":"Chin Tradit Herb Drug"},{"key":"e_1_2_5_18_1","unstructured":"ChenK.Isolation identification and biological activity of flavonoids from watercress. 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