{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:16:59Z","timestamp":1791555419155,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T00:00:00Z","timestamp":1594252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004242","name":"Princess Nourah Bint Abdulrahman University","doi-asserted-by":"publisher","award":["Fast\u2010Track research funding program"],"award-info":[{"award-number":["Fast\u2010Track research funding program"]}],"id":[{"id":"10.13039\/501100004242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Chronic exposure to arsenic (As) leads to serious renal disorders. Chlorogenic acid (CGA), a phenolic compound, has several well known physiological benefits, including antioxidant and anti\u2010inflammatory activities. The present study investigated the potential renoprotective effects of CGA on sodium arsenite (NaAsO<jats:sub>2<\/jats:sub>)\u2010induced kidney damage in mice. The mice were randomly allocated into five groups to receive daily treatment with CGA (200\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>), NaAsO<jats:sub>2<\/jats:sub> (5 mg\u2009kg<jats:sup>\u22121<\/jats:sup>), NaAsO<jats:sub>2<\/jats:sub> +\u2009CGA (100\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>), NaAsO<jats:sub>2<\/jats:sub> +\u2009CGA (200\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>), or a control for 28\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In the NaAsO<jats:sub>2<\/jats:sub>\u2010treated group, NaAsO<jats:sub>2<\/jats:sub> induced significant renal dysfunction, oxidative damage, inflammation, and apoptosis, as demonstrated by marked increases in urea and creatinine levels accompanied by a decrease in the kidney index. Considerable increases in malondialdehyde and nitric oxide levels and parallel decreases in various antioxidant markers (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione) levels were also detected in the renal tissues of NaAsO<jats:sub>2<\/jats:sub>\u2010treated mice. NaAsO<jats:sub>2<\/jats:sub> exposure was associated with marked increases in renal inflammatory markers (interleukin\u20101<jats:italic>\u03b2<\/jats:italic> and tumor necrosis factor\u2010<jats:italic>\u03b1<\/jats:italic>) and apoptosis indicators including Bax and caspase\u20103 levels contaminant, with a marked decrease in Bcl\u20102, an anti\u2010apoptotic protein, in the NaAsO<jats:sub>2<\/jats:sub>\u2010treated group compared with the control group. However, pretreatment with CGA substantially mitigated the renal injury and dysfunction associated with NaAsO<jats:sub>2<\/jats:sub> exposure by reducing tissue inflammation and apoptosis and improving the antioxidant status. The CGA pretreatment also alleviated the NaAsO<jats:sub>2<\/jats:sub>\u2010induced histological alterations in renal tissues.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Taken together, our results suggest the efficacy of CGA in alleviating As\u2010mediated renal tissue damage. \u00a9 2020 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.10565","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T07:05:11Z","timestamp":1591772711000},"page":"5162-5170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Nephroprotective effects of chlorogenic acid against sodium arsenite\u2010induced oxidative stress, inflammation, and apoptosis"],"prefix":"10.1002","volume":"100","author":[{"given":"Wafa A","family":"AL\u2010Megrin","sequence":"first","affiliation":[{"name":"Biology Department, Faculty of Science Princess Nourah Bint Abdulrahman 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