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This study evaluated the positive effects of different concentrations of Cnz on the intestinal bacterial core, enterobacterial composition and mucosal barrier function in a pig model.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Microbiota sequencing results showed that Cnz could significantly alter the intestinal microbiota composition and metabolism. Besides increasing the richness indices (ACE and Chao1), 10% Cnz could protect the intestinal mucosal barrier through increasing the expression of occludin and zonula occludens\u20101 in the small intestine, increase the abundance of Lachnospiraceae UCG\u2010004 and decrease the abundance of <jats:italic>Ruminococcus flavefaciens<\/jats:italic> compared to high ZnO diet and 5% Cnz material.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Cnz material at 10% supplementation is more effective than a level of 5% Cnz in increasing intestinal barrier through affecting gut microbiota. \u00a9 2020 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.10686","type":"journal-article","created":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T08:26:55Z","timestamp":1595579215000},"page":"735-745","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Effects of different concentrations of coated nano zinc oxide material on fecal bacterial composition and intestinal barrier in weaned piglets"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5710-8624","authenticated-orcid":false,"given":"Hongnan","family":"Liu","sequence":"first","affiliation":[{"name":"National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Key Laboratory of Agro\u2010ecological Processes in Subtropical Region, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South\u2010Central, Ministry of Agriculture, Hunan Provincial Engineering Research Center for Healthy Breeding of Livestock and Poultry, Institute of Subtropical Agriculture Chinese Academy of Sciences  Changsha China"},{"name":"Hangzhou King Techina Technology Company Academician Expert Workstation, Hangzhou King Techina Technology Co. 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