{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:28:25Z","timestamp":1760920105101,"version":"build-2065373602"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T00:00:00Z","timestamp":1600214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81260092","81641010","30960171"],"award-info":[{"award-number":["81260092","81641010","30960171"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2021,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Favism is an acute hemolytic syndrome caused by fava bean (FB) ingestion. The purpose of this study was to investigate the possible influences of FB on the metabonomic profile of erythrocytes in glucose\u20106\u2010phosphate dehydrogenase (G6PD)\u2010deficient (G6PDx) and wild\u2010type (WT) mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Ninety\u2010two metabolites were identified in the comparison of the G6PDx and WT groups. Eighty\u2010seven metabolites were identified in the erythrocytes of WT and G6PDx mice after FB ingestion. Thirty\u2010eight metabolites were identified in the comparison of the FB\u2010treated G6PDx and the FB\u2010treated WT mouse groups. Among them, the number of glycerophospholipids (GPLs) and polyunsaturated fatty acids (PUFAs) changed significantly, which suggests that GPLs and PUFAs may be responsible for FB stress.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>This study demonstrates that G6PD deficiency might affect the metabonomic profile of erythrocytes in response to FB. \u00a9 2020 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.10775","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T07:27:40Z","timestamp":1598945260000},"page":"1562-1571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Metabolic profiling reveals alterations in the erythrocyte response to fava bean ingestion in <scp>G6PD<\/scp>\u2010deficient 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