{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:54:29Z","timestamp":1790780069866,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2017T100373"],"award-info":[{"award-number":["2017T100373"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2016M600417"],"award-info":[{"award-number":["2016M600417"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010014","name":"Six Talent Peaks Project in Jiangsu Province","doi-asserted-by":"publisher","award":["2015\u2010JY\u2010016"],"award-info":[{"award-number":["2015\u2010JY\u2010016"]}],"id":[{"id":"10.13039\/501100010014","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2021,3,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Ginkgo biloba<\/jats:italic>\n                      seeds are well known for the significant curative effects on relieving cough and asthma. However, the development of products from ginkgo seeds still falls behind at present, resulting in a great waste of ginkgo seeds' resource. In this work, submerged fermentation of ginkgo seed powder using\n                      <jats:italic>Eurotium cristatum<\/jats:italic>\n                      was studied to investigate its feasibility as a new processing method.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      To promote the growth of\n                      <jats:italic>E. cristatum<\/jats:italic>\n                      , the optimum fermentation medium was 80.0 g\u2009L\n                      <jats:sup>\u22121<\/jats:sup>\n                      of ginkgo seed powder with addition of 5.0 g\u2009L\n                      <jats:sup>\u22121<\/jats:sup>\n                      calcium chloride (CaCl\n                      <jats:sub>2<\/jats:sub>\n                      ), 4.0 g\u2009L\n                      <jats:sup>\u22121<\/jats:sup>\n                      magnesium sulfate (MgSO\n                      <jats:sub>4<\/jats:sub>\n                      ), 1.25\u2009g\u2009L\n                      <jats:sup>\u22121<\/jats:sup>\n                      zinc sulfate (ZnSO\n                      <jats:sub>4<\/jats:sub>\n                      ) and 0.65\u2009g\u2009L\n                      <jats:sup>\u22121<\/jats:sup>\n                      iron(II) sulfate (FeSO\n                      <jats:sub>4<\/jats:sub>\n                      ). The optimum fermentation conditions were pH 5.8\u2009\u00b1\u20090.1, inoculum size 5.1\u2009\u00d7\u200910\n                      <jats:sup>6<\/jats:sup>\n                      \u2009CFU\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      , liquid medium volume 100\u2009mL in 250\u2010mL Erlenmeyer flask and fermentation 4\u2009days. Through fermentation, the production of lovastatin in fermentation broth could reach up to 32.97\u2009\u00b1\u20090.17\u2009\u03bcg\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      and the total antioxidant capacity was improved by more than two\u2010fold. In addition, 40.15% of the ginkgotoxin in ginkgo seed powder was degraded while the entire degradation of ginkgolic acids was obtained. Moreover, fermented ginkgo seed powder suspension presented pleasant fragrances, and the activities of amylase and protease were enhanced to 11.30\u2009\u00b1\u20090.10 U\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      and 23.01\u2009\u00b1\u20090.20\u2009U\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      , respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      Submerged fermentation using\n                      <jats:italic>E. cristatum<\/jats:italic>\n                      could significantly enhance the functional value and safety of ginkgo seed powder, and had great potential to become a novel processing method for the development of ginkgo seeds fermented products. \u00a9 2020 Society of Chemical Industry\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.10792","type":"journal-article","created":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T06:30:05Z","timestamp":1599373805000},"page":"1782-1791","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Submerged fermentation of\n                    <scp>\n                      <i>Ginkgo biloba<\/i>\n                    <\/scp>\n                    seed powder using\n                    <scp>\n                      <i>Eurotium cristatum<\/i>\n                    <\/scp>\n                    for the development of ginkgo seeds fermented products"],"prefix":"10.1002","volume":"101","author":[{"given":"Minmin","family":"Zou","sequence":"first","affiliation":[{"name":"Department of Food Science and Technology, College of Light Industry and Food Engineering Nanjing Forestry University  Nanjing China"},{"name":"Co\u2010innovation Center for the Sustainable Forestry in Southern China, College of Forestry Nanjing Forestry University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6227-8644","authenticated-orcid":false,"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, College of Light Industry and Food Engineering Nanjing Forestry University  Nanjing China"},{"name":"Co\u2010innovation Center for the Sustainable Forestry in Southern China, College of Forestry Nanjing Forestry University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihui","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, College of Light Industry and Food Engineering Nanjing Forestry University  Nanjing China"},{"name":"Co\u2010innovation Center for the Sustainable Forestry in Southern China, College of Forestry Nanjing Forestry University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, College of Light Industry and Food Engineering Nanjing Forestry University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuliang","family":"Cao","sequence":"additional","affiliation":[{"name":"Co\u2010innovation Center for the Sustainable Forestry in Southern China, College of Forestry Nanjing Forestry University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3868-567X","authenticated-orcid":false,"given":"Erzheng","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, College of Light Industry and Food Engineering Nanjing Forestry University  Nanjing China"},{"name":"Co\u2010innovation Center for the Sustainable Forestry in Southern China, College of Forestry Nanjing Forestry University  Nanjing China"},{"name":"Co\u2010Innovation Center for Efficient Processing and Utilization of Forest Products Nanjing Forestry University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2009.01.013"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2008.05.007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2019.111622"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10590500701569414"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfoodeng.2006.09.021"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfca.2019.103247"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11694-019-00341-y"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.15302\/J-FASE-2017181"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.2.325"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2018.06.046"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2018.07.173"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2006.02963.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2011.01.024"},{"key":"e_1_2_7_15_1","first-page":"48","article-title":"Study on bioactivity of extracellular polysaccharide of Eurotium cristatum by high throughput screening","volume":"23","author":"Deng FM","year":"2007","journal-title":"Food Mach"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiosc.2017.10.011"},{"key":"e_1_2_7_17_1","first-page":"336","article-title":"Research process on medical value of Eurotium cristatum","volume":"39","author":"Xun JQ","year":"2018","journal-title":"Sci Technol Food Ind"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2012.05.088"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/pr7090627"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfpp.12694"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2018.08.007"},{"key":"e_1_2_7_22_1","first-page":"93","article-title":"Effect of Eurotium cristatum on flavones content in Avena sativa L","volume":"38","author":"Liu SX","year":"2018","journal-title":"China Brew"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18122754"},{"key":"e_1_2_7_24_1","volume-title":"Determination of Total Sugars Content in Edible Fungi (GB\/T15672\u20102009)","author":"National Standard of the People\u2032s Republic of China","year":"2009"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11094-018-1807-4"},{"key":"e_1_2_7_26_1","volume-title":"Determination of Oil in Food (GB 5009.6\u20132016)","author":"National Standard of the People\u2032s Republic of China","year":"2016"},{"key":"e_1_2_7_27_1","volume-title":"Determination of Starch in Food (GB 5009.9\u20132016)","author":"National Standard of the People\u2032s Republic of China","year":"2016"},{"key":"e_1_2_7_28_1","volume-title":"Determination of Reducing Sugars in Food (GB 5009.7\u20132016)","author":"National Standard of the People\u2032s Republic of China","year":"2016"},{"key":"e_1_2_7_29_1","first-page":"20180094","article-title":"Improvement of quality and digestibility of Moringa oleifera leaves feed via solid\u2010state fermentation by Aspergillus niger","volume":"16","author":"Wang JH","year":"2018","journal-title":"Int J Chem React Eng"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/10826076.2017.1309661"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7GC03820H"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.24523"},{"key":"e_1_2_7_33_1","first-page":"409","article-title":"Submerged liquid fermentation of raw dark tea by Eurotium cristatum","volume":"17","author":"Zou MM","year":"2019","journal-title":"Chin J Bioprocess Eng"},{"key":"e_1_2_7_34_1","first-page":"49","article-title":"Progress in the research and application of the Eurotium cristatum","volume":"15","author":"Huang Y","year":"2017","journal-title":"Chin J Bioprocess Eng"},{"key":"e_1_2_7_35_1","first-page":"20","article-title":"Study on growth conditions of Jinhua fungus in Fu zhuan tea","volume":"9","author":"Liu ZY","year":"1991","journal-title":"Guizhou Sci"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2004.12.001"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12257-008-0014-7"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00217-014-2337-2"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2018.11.006"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1128\/BR.34.3.278-343.1970"},{"key":"e_1_2_7_41_1","first-page":"20","article-title":"Effects of the fermentation of jinghua fungus on the main chemical constituents of Tie\u2010Guan\u2010Yin tea","volume":"42","author":"Yang JM","year":"2015","journal-title":"Guangdong Agric Sci"},{"key":"e_1_2_7_42_1","first-page":"917","article-title":"Study on the effect of dark tea fermentation liquid with Eurotium cristatum on the activity of digestive enzyme","volume":"5","author":"Huang Q","year":"2007","journal-title":"Microbiology"}],"container-title":["Journal of the Science of Food and Agriculture"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jsfa.10792","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jsfa.10792","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jsfa.10792","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:56:44Z","timestamp":1760875004000},"score":1,"resource":{"primary":{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/10.1002\/jsfa.10792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,21]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,3,30]]}},"alternative-id":["10.1002\/jsfa.10792"],"URL":"https:\/\/doi.org\/10.1002\/jsfa.10792","archive":["Portico"],"relation":{},"ISSN":["0022-5142","1097-0010"],"issn-type":[{"value":"0022-5142","type":"print"},{"value":"1097-0010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,21]]},"assertion":[{"value":"2020-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}