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The present study aimed to encapsulate folic acid at different concentrations (5, 10 and 15% (w\/w) on a dry basis) in potato starch nanofibers produced through electrospinning. The starch\/folic acid nanofibers were evaluated through morphology, Fourier transform infrared (FTIR) spectra, thermal properties, encapsulation efficiency (EE) and <jats:italic>in vitro<\/jats:italic> simulation of the human digestion. The nanofibers were also evaluated based on the folic acid content after thermal treatment (100 and 180\u2009\u00b0C) and UVA irradiation (1 and 24\u2009h).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Folic acid incorporation influenced the morphology of the nanofibers to display a homogeneous and beadless morphology for nanofibers containing 15% folic acid compared with the other nanofibers (0, 5 and 10% folic acid). The mean diameter varied from 75 to 81\u2009nm. Folic acid characteristic bands and peaks were not found in the nanofiber FTIR spectra and thermograms, respectively. The EE was 73, 87 and 95% for nanofibers with 5, 10 and 15% folic acid, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The starch nanofibers protected folic acid from high temperature and UVA irradiation and during <jats:italic>in vitro<\/jats:italic> digestion, showing a release of the vitamin at the end of the simulation (intestinal conditions). The supplementation of folic acid in foods can be effectively achieved by its encapsulation into starch nanofibers, to ensure its protection and controlled release. \u00a9 2020 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.10809","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T13:50:57Z","timestamp":1600955457000},"page":"1935-1943","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Starch nanofibers as vehicles for folic acid supplementation: thermal treatment, <scp>UVA<\/scp> irradiation and <i>in vitro<\/i> simulation of digestion"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6012-1275","authenticated-orcid":false,"given":"Laura M","family":"Fonseca","sequence":"first","affiliation":[{"name":"Department of Agroindustrial Science and Technology Federal University of Pelotas  Pelotas 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