{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T04:26:15Z","timestamp":1773721575209,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T00:00:00Z","timestamp":1604016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2019PH020"],"award-info":[{"award-number":["ZR2019PH020"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Hyperlipidemia is one of the metabolic disorders that poses a great threat to human health. This study is aimed at investigating the potential hypolipidemic properties of extract from peanut meal fermented with <jats:italic>Bacillus natto<\/jats:italic> and <jats:italic>Monascus<\/jats:italic> in mice fed with a high\u2010fat diet. Herein, 60 male C57BL\/6J mice were randomly divided into six groups: four control groups, comprised of a normal group, a model (M) group, a positive control group (atorvastatin 10\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>), and a nonfermented peanut meal extract group (150\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>), and two experimental groups, comprised of a fermented peanut meal extract low\u2010dose group (50\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>) and a fermented peanut meal extract high\u2010dose group (FH, 150\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Body weight (<jats:italic>P<\/jats:italic> = 0.001) and levels of serum total cholesterol (<jats:italic>P<\/jats:italic> = 0.007), triacylglycerol (<jats:italic>P<\/jats:italic> = 0.040), low\u2010density lipoprotein cholesterol (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and leptin (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) were remarkably decreased in the FH group, whereas the serum high\u2010density lipoprotein cholesterol levels were increased (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) by 78.3% compared with the M group. Ileum tissue stained with hematoxylin and eosin showed that the ileal villus detachments in mice were improved, and the villus height was increased by supplementation with extract from fermented peanut meal. Moreover, the expressions of intestinal ZO\u20101 (<jats:italic>P<\/jats:italic> = 0.003) and occludin (<jats:italic>P<\/jats:italic> = 0.013) were elevated in the FH group, compared with the M group.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Extract of peanut meal fermented by <jats:italic>B. natto<\/jats:italic> and <jats:italic>Monascus<\/jats:italic> can effectively improve hyperlipidemia caused by a high\u2010fat diet in mice, via regulating leptin and blood lipid levels, and protect the intestinal mucosal barrier, which provides evidence for its anti\u2010hyperlipidemia effects and is a research basis for potential industrial development. \u00a9 2020 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.10884","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T02:44:11Z","timestamp":1602816251000},"page":"2561-2569","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Effects of the extract from peanut meal fermented with <i>Bacillus natto<\/i> and <i>Monascus<\/i> on lipid metabolism and intestinal barrier function of hyperlipidemic mice"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9651-883X","authenticated-orcid":false,"given":"Yaqian","family":"Lu","sequence":"first","affiliation":[{"name":"School of Public Health, Medical College Qingdao University  Qingdao China"},{"name":"Institute of Biomedical Engineering, College of Life Sciences Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoyue","family":"Ding","sequence":"additional","affiliation":[{"name":"School of Public Health, Medical College Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyang","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Public Health, Medical College Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Public Health, Medical College Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiguo","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Public Health, Medical College Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingfen","family":"Hu","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, College of Life Sciences Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zichao","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, College of Life Sciences Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,30]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"S139","article-title":"Epidemiology and management of hyperlipidemia","volume":"23","author":"Karr S","year":"2017","journal-title":"Am J Managed Care"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7FO00701A"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.128413"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114516004621"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11130-017-0632-3"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9121310"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12010-016-2163-z"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13197-011-0449-2"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ps\/80.3.306"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114519002988"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/10942912.2012.675605"},{"key":"e_1_2_9_13_1","first-page":"1","article-title":"Anaerobic fermentation of peanut meal to produce even\u2010chain volatile fatty acids using Saccharomyces cerevisiae inoculum","author":"Zhang L","year":"2020","journal-title":"Environ Technol"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2012.00508.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8FO01146J"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1177271918785130"},{"key":"e_1_2_9_17_1","first-page":"2038","article-title":"A clinical study on the effect of nattokinase on carotid artery atherosclerosis and hyperlipidaemia","volume":"97","author":"Ren NN","year":"2017","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_9_18_1","first-page":"192","article-title":"Research status and application prospects of Monascus sp","volume":"16","author":"Lu W","year":"2015","journal-title":"Agric Sci Technol"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025338"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10295-012-1216-8"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-016-0451-2"},{"key":"e_1_2_9_22_1","first-page":"415","article-title":"Study on the effect of precipitation of milk protein by trichloroacetic acid analyzing with biuret spectrophotometry method","volume":"5","author":"Xiao LR","year":"2011","journal-title":"Sci Technol Food Ind"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0038-0717(02)00203-1"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-7012(02)00151-3"},{"key":"e_1_2_9_25_1","first-page":"88","article-title":"Determination of the soluble polysaccharide, flavone and polyphenol in Canavium album Raeuseh","volume":"7","author":"Luo YH","year":"2014","journal-title":"Food Res Dev"},{"key":"e_1_2_9_26_1","first-page":"64","article-title":"Screening of \u03b3\u2010aminobutyric acid Monascus strain and its fermentation conditions","volume":"47","author":"Hu S","year":"2011","journal-title":"Food Ferment Technol"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02932582"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008893627877"},{"key":"e_1_2_9_29_1","first-page":"256","article-title":"Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research","volume":"20","author":"Kilkenny C","year":"2012","journal-title":"PLoS Biol"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-2742-5_9"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2017.1383355"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2013.10.016"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508043808"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00240-9"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2014.04.003"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2017.04.011"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.09.027"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.12717\/DR.2019.23.4.305"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0396.2011.01151.x"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2010.00845.x"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6107(02)00037-8"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700050"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2003.03032.x"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1987.253.1.C171"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8030126"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-5364(17)30104-8"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-19013-2"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00243.2009"},{"key":"e_1_2_9_49_1","first-page":"2819154","article-title":"Regulation of intestinal epithelial cells properties and functions by amino acids","author":"Kong S","year":"2018","journal-title":"Biomed Res Int"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/asj.13357"}],"container-title":["Journal of the Science of Food and Agriculture"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jsfa.10884","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jsfa.10884","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jsfa.10884","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T13:45:22Z","timestamp":1760881522000},"score":1,"resource":{"primary":{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/10.1002\/jsfa.10884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,30]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1002\/jsfa.10884"],"URL":"https:\/\/doi.org\/10.1002\/jsfa.10884","archive":["Portico"],"relation":{},"ISSN":["0022-5142","1097-0010"],"issn-type":[{"value":"0022-5142","type":"print"},{"value":"1097-0010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,30]]},"assertion":[{"value":"2020-06-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}