{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T09:10:11Z","timestamp":1789722611473,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31702127"],"award-info":[{"award-number":["31702127"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Iron supplements are limited by their poor absorption and low efficacy. A circadian feeding schedule would affect the circadian rhythm and improve nutrient metabolism. In this study, 18 iron\u2010deficient piglets were randomly assigned to three groups: a control group receiving a constant diet with mid\u2010iron (MI), a \u2018HL\u2019 group receiving a high\u2010iron (HI) diet at 8:00\u2009h and a low\u2010iron (LI) diet at 18:00, and an \u2018LH\u2019 group receiving a LI diet at 8:00 and a HI diet at 18:00. The effects of circadian iron administration on iron absorption, iron status, and biological rhythm in iron\u2010deficient piglets were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Serum iron and hemoglobin improved significantly (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;\u20090.05) but did not significantly differ in the circadian iron\u2010feeding groups (\n                      <jats:italic>P<\/jats:italic>\n                      &gt;\u20090.05). Iron concentration in the liver and spleen was significantly higher in the LH group than in the HL group (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;\u20090.05), and mRNA expression of divalent metal transport 1 (DMT1), cytochrome B (CYBRD1) and ferroportin (FPN) genes in the duodenum was significantly elevated in the LH group (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;\u20090.05). The clock\u2010related genes showed differential expression in the duodenum, with greater mRNA expression for period (Per2) and cryptochrome (Cry1 and Cry2) in the LH group (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Circadian iron administration affected iron absorption and iron storage in pigs. Iron supplementation in the evening might be a more effective pattern for iron utilization. The rhythmic system in the intestine, driven by the time, played an important role in this process. \u00a9 2020 Society of Chemical Industry<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.10897","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T03:45:55Z","timestamp":1604029555000},"page":"2712-2717","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effects of circadian iron administration on iron bioavailability and biological rhythm in pigs"],"prefix":"10.1002","volume":"101","author":[{"given":"Zhenglin","family":"Dong","sequence":"first","affiliation":[{"name":"Key Laboratory of Agro\u2010Ecological Processess in Subtropical Region, Hunan Research Center of Livestock &amp; Poultry Sciences, South\u2010Central Experimental Station of Animal Nutrition and Feed Science in Ministry of Agriculture Institute of Subtropical Agriculture, The Chinese Academy of 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