{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:25:21Z","timestamp":1792725921476,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T00:00:00Z","timestamp":1605830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Alcoholic liver disease (ALD) refers to liver damage caused by long\u2010term heavy drinking, which causes oxidative stress and changes in gut microbiota. In this paper, we investigated the hepatoprotective effect of sea buckthorn fermentation liquid on ALD in mice and the interaction between ALD and gut microbiota using animal experiments and gut microbiota measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>We found that the contents of total flavonoids, total triterpenes and related short\u2010chain fatty acids (SCFAs) in sea buckthorn fermentation liquid (SFL) were significantly greater. Liver index, kidney index, spleen index, serum indexes of liver injury \u2013 alanine aminotransferase (ALT) and spartate aminotransferase (AST), inflammatory factors in liver tissues \u2013 tumor necrosis factor\u2010<jats:italic>\u03b1<\/jats:italic> (TNF\u2010<jats:italic>\u03b1<\/jats:italic>) and interleukin\u20106 (IL\u20106), oxidation indexes \u2013 malondialdehyde (MDA) and superoxide dismutase (SOD), and lipid metabolism indexes \u2013 high\u2010density liptein cholesterol (HDL\u2010C), low density lipoprotein cholesterol (LDL\u2010C), and triglyceride (TG), suggested that SFL significantly ameliorates liver injury caused by alcohol. By measuring gut microbiota in mice feces samples, we found that the high\u2010dose group of SFL reversed the declining trend of the gut microbiota Firmicutes\/Bacteroidetes (F\/B) ratio caused by alcohol, reducing the number of gram\u2010negative bacteroidetes. <jats:italic>Patescibacteria<\/jats:italic> was tightly connected with the indicators of ALD. At the genus level, high\u2010dose SFL significantly downregulated <jats:italic>Akkermansia<\/jats:italic>, <jats:italic>Turicibacter<\/jats:italic>, <jats:italic>Alistipes<\/jats:italic> and <jats:italic>Ruminiclostridium<\/jats:italic>, and improved the abundance of beneficial bacteria in <jats:italic>Lactobacillus<\/jats:italic>. In addition, <jats:italic>Alistipes<\/jats:italic> and <jats:italic>Ruminiclostridium<\/jats:italic> was closely connected with the indicators of ALD.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Sea buckthorn fermentation liquid protected against alcoholic liver disease and modulated the composition of gut microbiota. \u00a9 2020 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.10915","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T22:37:11Z","timestamp":1604443031000},"page":"2846-2854","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Sea buckthorn (<scp><i>Hippophae rhamnoides<\/i><\/scp> L.) fermentation liquid protects against alcoholic liver disease linked to regulation of liver metabolome and the abundance of gut microbiota"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7660-4378","authenticated-orcid":false,"given":"Beibei","family":"Ran","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010E","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing PR China"},{"name":"Engineering Research Center of Good Agricultural Practice for Chinese Crude Drugs Ministry of Education  Beijing P. 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