{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:23:04Z","timestamp":1791994984906,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31971641"],"award-info":[{"award-number":["31971641"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY16C160011"],"award-info":[{"award-number":["LY16C160011"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2021,8,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Purple corn (\n                      <jats:italic>Zea mays<\/jats:italic>\n                      L.) is one of the main economic crops in China and has been used in the treatment of cystitis, urinary infections and obesity. However, purple corncobs, the by\u2010product remaining after processing and having an intense purple\u2010black color, are normally disposed of as waste or used as animal feed. Therefore, to further expand the medicinal value of purple corncob, its content was analyzed and, after purification, the effect and mechanism of purified purple corncob anthocyanins (PPCCA) on CCl\n                      <jats:sub>4<\/jats:sub>\n                      \u2010induced chronic liver injury in mice were investigated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      It was observed that the total anthocyanin content (TAC) from PPCCA (317.51\u2009\u00b1\u20099.30\u2009mg cyanidin 3\u2010\n                      <jats:italic>O<\/jats:italic>\n                      \u2010glucoside (C\u20103\u2010G)\u00a0g\n                      <jats:sup>\u22121<\/jats:sup>\n                      dry weight) was significantly higher than that from the purified purple corn seed anthocyanin (266.73\u2009\u00b1\u20093.67\u2009mg C\u20103\u2010G\u2009g\n                      <jats:sup>\u22121<\/jats:sup>\n                      dry weight), of which C\u20103\u2010G accounted for 90.6% and 90.4% of the TAC, respectively. Furthermore, compared with the CCl\n                      <jats:sub>4<\/jats:sub>\n                      group, PPCCA treatment significantly reduced liver index, serum total bilirubin, alanine transaminase, aspartate transaminase and liver malondialdehyde levels, but increased liver superoxide dismutase activity. The pathological changes were also improved, such as more regular arrangement of hepatocytes, less swelling, and fewer vacuoles and apoptotic cells. Additionally, mechanistic studies showed that PPCCA downregulated the expression of Caspase\u20103, Bax and cytochrome P450 2E1 proteins in the liver and upregulated the expression of Bcl\u20102.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      These results demonstrated that PPCCA could ameliorate CCl\n                      <jats:sub>4<\/jats:sub>\n                      \u2010induced chronic liver injury by regulating oxidative stress and hepatocyte apoptosis pathways. \u00a9 2021 Society of Chemical Industry\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.11112","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T13:12:46Z","timestamp":1611580366000},"page":"4672-4680","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Purified anthocyanins from\n                    <scp>\n                      <i>Zea mays<\/i>\n                    <\/scp>\n                    L. cob ameliorates chronic liver injury in mice via modulating of oxidative stress and apoptosis"],"prefix":"10.1002","volume":"101","author":[{"given":"Hong\u2010Xin","family":"Cui","sequence":"first","affiliation":[{"name":"College of Pharmacy Henan University of Chinese Medicine  Zhengzhou China"},{"name":"Co\u2010construction Collaborative Innovation Center for Chinese Medicine and Respiratory Disease by Henan &amp; Education Ministry of PR China  Zhengzhou 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