{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:48:51Z","timestamp":1786978131459,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2021,8,30]]},"abstract":"Abstract<\/jats:title>\n \n BACKGROUND<\/jats:title>\n \n Fruit juice is usually rich in monosaccharides and disaccharides. A reverse osmosis separation machine was used to remove monosaccharides and disaccharides from\n \n Hovenia dulcis<\/jats:italic>\n <\/jats:styled-content>\n fruit juice, leaving behind most of the bioactive substances in a low\u2010sugar fruit juice (\n LSFJ<\/jats:styled-content>\n ), so as to provide a more effective treatment for diabetic patients.\n <\/jats:p>\n <\/jats:sec>\n \n METHOD<\/jats:title>\n \n This study was carried out with type\u00a01 diabetes mellitus model induced with high dose of streptozotocin (60\u2009mg\u2009kg\n \u22121<\/jats:sup>\n ), and oral administration of\n LSFJ<\/jats:styled-content>\n for 4\u2009weeks.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n LSFJ<\/jats:styled-content>\n treatment led to significant gain in body weight and increased serum insulin level,\n insulin\u2010like growth factor<\/jats:styled-content>\n \u20101 level, blood urea nitrogen level, creatinine level, and hepatic glycogen level. Meanwhile, fasting blood glucose, fructosamine level, and glucose tolerance were also observably enhanced. Additional,\n LSFJ<\/jats:styled-content>\n treatment significantly improved lipid metabolism, islet quality, and islet oxidative stress. The\n messenger RNA<\/jats:styled-content>\n levels of glucose metabolism genes in the pancreas of diabetic rats decreased in the\n diabetes model<\/jats:styled-content>\n group, whereas\n messenger RNA<\/jats:styled-content>\n expression of these genes was significantly increased with\n LSFJ<\/jats:styled-content>\n treatment.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n \n These findings indicate that\n LSFJ<\/jats:styled-content>\n can improve symptoms associated with\n type\u20091 diabetes mellitus<\/jats:styled-content>\n . The research also suggests new strategies for diabetes prevention and treatment. \u00a9 2021 Society of Chemical Industry\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jsfa.11128","type":"journal-article","created":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T09:26:46Z","timestamp":1611739606000},"page":"4818-4828","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hypoglycemic effect of low\u2010sugar juice derived from\n \n Hovenia dulcis<\/i>\n <\/scp>\n on\n type 1 diabetes mellitus<\/scp>\n rats"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6989-6656","authenticated-orcid":false,"given":"Bing","family":"Yang","sequence":"first","affiliation":[{"name":"College of Food Science Southwest University Chongqing China"},{"name":"College of Food Science and Technology Hebei Agricultural University Baoding China"},{"name":"Laboratory of Quality & Safety Risk Assessment for 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