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Furthermore, some studies mention a potential synergistic effect with omega\u20103 polyunsaturated fatty acids, comprising other bioactive compounds extremely unstable and susceptible to oxidation. A relatively novel strategy to avoid oxidation processes is to transform liquid oils into three\u2010dimensional structures by adding a gelling agent and forming a self\u2010assembled network that can later be vectorized by incorporating it into other systems. The present study aimed to design and optimize an oil gelled\u2010in\u2010water curcumin\u2010loaded emulsion to maximize curcumin stability and minimize lipid oxidation in terms of some critical operating parameters, such as dispersed phase, emulsifier and stabilizer concentrations, and homogenization rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The operating conditions that had a significant effect on the formulation were the dispersed phase weight fraction affecting droplet size and total lipid oxidation, homogenization conditions affecting droplet size and primary lipid oxidation, and emulsifier concentration affecting droplet size (significance level\u00a0=\u00a095%). The optimal formulation for maximizing curcumin load and minimizing lipid oxidation in the oleogelified matrix was 140.4\u00a0g\u2009kg<jats:sup>\u22121<\/jats:sup> dispersed phase, 50.0\u00a0g\u2009kg<jats:sup>\u22121<\/jats:sup> emulsifier, 4.9\u00a0g\u2009kg<jats:sup>\u22121<\/jats:sup> stabilizer and homogenization speed 1016\u2009\u00d7\u2009<jats:italic>g<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The results obtained in the present study provide a valuable tool for the rational design and development of oil gelled\u2010in\u2010water emulsions that stabilize and transport bioactive compounds such as curcumin. \u00a9 2021 The Authors. <jats:italic>Journal of The Science of Food and Agriculture<\/jats:italic> published by John Wiley &amp; Sons Ltd on behalf of Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.11310","type":"journal-article","created":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T07:00:43Z","timestamp":1620630043000},"page":"6395-6406","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effect of operating parameters on the physical and chemical stability of an oil gelled\u2010in\u2010water emulsified curcumin delivery system"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1795-3268","authenticated-orcid":false,"given":"Jose Antonio","family":"Vellido\u2010Perez","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering, Faculty of Sciences University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5564-7619","authenticated-orcid":false,"given":"Javier Miguel","family":"Ochando\u2010Pulido","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Faculty of Sciences University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5225-9941","authenticated-orcid":false,"given":"Edmundo","family":"Brito\u2010de la Fuente","sequence":"additional","affiliation":[{"name":"Innovation &amp; Development Centers China &amp; Germany Business Unit Parenteral Nutrition, Ketoanalogues &amp; IV Fluids Pharmaceuticals &amp; Devices Division Fresenius Kabi Deutschland GmbH  Bad Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5750-7900","authenticated-orcid":false,"given":"Antonio","family":"Martinez\u2010Ferez","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Faculty of Sciences University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.05.009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2011.05648.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2014.04.004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules20022728"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phanu.2015.08.001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21030264"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2018.01.016"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10101553"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2019.110460"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.03.025"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1358\/dof.2010.035.02.1426640"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13621"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.618785"},{"key":"e_1_2_7_15_1","unstructured":"PubChem\u2010969516.PubChem Compound Database; CID=969516. 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