{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:31:41Z","timestamp":1790832701835,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T00:00:00Z","timestamp":1625443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31272468"],"award-info":[{"award-number":["31272468"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31772643"],"award-info":[{"award-number":["31772643"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2022,1,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Heat stress (HS) has a negative impact on the intestinal barrier and immune function of pigs. Selenium (Se) may improve intestinal health through affecting selenoproteins. Thus we investigate the protective effect of new organic Se (2\u2010hydroxy\u20104\u2010methylselenobutanoic acid, HMSeBA) on jejunal damage in growing pigs upon HS and integrate potential roles of corresponding selenoproteins.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>HS decreased the villus height and increased (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) the protein abundance of HSP70, and downregulated (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) protein levels of tight junction\u2010related proteins (CLDN\u20101 and OCLD). HS\u2010induced jejunal damage was associated with the upregulation of four inflammation\u2010related genes and ten selenoprotein\u2010encoding genes, downregulation (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) of four selenoprotein\u2010encoding genes and decreased (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) the protein abundance of GPX4 and SELENOS. Compared with the HS group, HMSeBA supplementation not only elevated the villus height and the ratio of V\/C (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090:05), but also reduced (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) the protein abundance of HSP70 and MDA content, and increased (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) the protein abundance of OCLD. HMSeBA supplementation downregulated the expression of seven inflammation\u2010related genes, changed the expression of 12 selenoprotein\u2010encoding genes in jejunum mucosa affected by HS, and increased the protein abundance of GPX4, TXNRD1 and SELENOS.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Organic Se supplementation beyond nutritional requirement alleviates the negative effect of HS on the jejunum of growing pigs, and its protective effect is related to the response of corresponding selenoproteins. \u00a9 2021 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.11377","type":"journal-article","created":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T07:34:23Z","timestamp":1624088063000},"page":"496-504","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Selenium exerts protective effects against heat stress\u2010induced barrier disruption and inflammation response in jejunum of growing pigs"],"prefix":"10.1002","volume":"102","author":[{"given":"Ying","family":"He","sequence":"first","affiliation":[{"name":"Animal Nutrition Institute, Sichuan Agricultural University  Chengdu China"},{"name":"Key Laboratory for Animal Disease\u2010resistance Nutrition Ministry of Education  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Animal Nutrition Institute, Sichuan Agricultural University  Chengdu China"},{"name":"Key Laboratory for Animal Disease\u2010resistance Nutrition Ministry of Education  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayong","family":"Tang","sequence":"additional","affiliation":[{"name":"Animal Nutrition Institute, Sichuan Agricultural University  Chengdu China"},{"name":"Key Laboratory for Animal Disease\u2010resistance Nutrition Ministry of Education  Chengdu 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